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Biochemistry

By Reginald H. Garrett, Charles M. Grisham

7th Edition © 2024
Discipline:Chemistry
Course:Biochemistry
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Ideal for readers encountering biochemistry for the first time, Garrett and Grisham’s BIOCHEMISTRY, Seventh Edition, makes even complex course concepts accessible for today’s learners while revealing the beauty and usefulness of biochemistry in the everyday world. This engaging text illuminates the fundamental principles governing the structure, function and interactions of biological molecules, providing a solid foundation in biochemistry for undergraduates majoring in life sciences, chemistry or premedical programs, as well as medical and graduate health sciences students seeking a deeper understanding of human physiology.

Updated to reflect tremendous recent developments in biochemistry, the Seventh Edition features new and revised material and presentations throughout the text, incorporating additional content while maintaining a balanced and streamlined presentation. In addition, the authors emphasize the interrelationships of ideas to help readers appreciate the overarching questions of biochemistry. The text is also integrated with OWLv2, a powerful online learning system for chemistry with text-specific end-of-chapter material to engage readers and improve learning outcomes.

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AboutTable of contentsResourcesPricing & formatsRelated products

About this product

Ideal for readers encountering biochemistry for the first time, Garrett and Grisham’s BIOCHEMISTRY, Seventh Edition, makes even complex course concepts accessible for today’s learners while revealing the beauty and usefulness of biochemistry in the everyday world. This engaging text illuminates the fundamental principles governing the structure, function and interactions of biological molecules, providing a solid foundation in biochemistry for undergraduates majoring in life sciences, chemistry or premedical programs, as well as medical and graduate health sciences students seeking a deeper understanding of human physiology.

Updated to reflect tremendous recent developments in biochemistry, the Seventh Edition features new and revised material and presentations throughout the text, incorporating additional content while maintaining a balanced and streamlined presentation. In addition, the authors emphasize the interrelationships of ideas to help readers appreciate the overarching questions of biochemistry. The text is also integrated with OWLv2, a powerful online learning system for chemistry with text-specific end-of-chapter material to engage readers and improve learning outcomes.

The text is integrated with OWLv2, a powerful online learning platform for chemistry with text-specific end-of-chapter material to engage readers and improve learning outcomes.

Each chapter is framed around an Essential Question to engage readers and encourage curiosity about the subject matter.

At the end of each chapter, a Foundational Biochemistry feature provides a comprehensive list of the principal facts and concepts that readers should understand after completing the chapter.

Prepared especially for this book, over 1100 images of prominent proteins and nucleic acids involved with essential biological functions help illustrate and inform chapter content.

Table of contents

Chapters

Cover Page
Title Page
Copyright Page
Dedication
About the Authors
Careers in Chemistry
PSAFE (Protein Structure and Function Exploration)
Laboratory Techniques in Biochemistry
Preface
1. The Facts of Life: Chemistry Is the Logic of Biological Phenomena*Preview this chapter
2. Water: The Medium of Life
3. Thermodynamics of Biological Systems
4. Amino Acids and the Peptide Bond
5. Proteins: Their Primary Structure and Biological Functions
6. Proteins: Secondary, Tertiary, and Quaternary Structure
7. Carbohydrates and the Glycoconjugates of Cell Surfaces
8. Lipids
9. Membranes and Membrane Transport
10. Nucleotides and Nucleic Acids
11. Structure of Nucleic Acids
12. Recombinant DNA, Cloning, Gene Editing, and Synthetic Biology–An Introduction
13. Enzymes—Kinetics and Specificity
14. Mechanisms of Enzyme Action
15. Enzyme Regulation
16. Molecular Motors
17. Metabolism: An Overview
18. Glycolysis
19. The Tricarboxylic Acid Cycle
20. Electron Transport and Oxidative Phosphorylation
21. Photosynthesis
22. Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway
23. Fatty Acid Catabolism
24. Lipid Biosynthesis
25. Nitrogen Acquisition and Amino Acid Metabolism
26. Synthesis and Degradation of Nucleotides
27. Metabolic Integration and Organ Specialization
28. DNA Metabolism: Replication, Recombination, and Repair
29. Transcription and the Regulation of Gene Expression
30. Protein Synthesis
31. Completing the Protein Life Cycle: Folding, Processing, and Degradation
32. The Reception and Transmission of Extracellular Information
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1. The Facts of Life: Chemistry Is the Logic of Biological PhenomenaPreview this chapter ↗

1.1
What Are the Distinctive Properties of Living Systems? ↗
1.2
What Kinds of Molecules Are Biomolecules?
Preview this section ↗
1.2a. Biomolecules Are Carbon Compounds ↗
1.3
What Is the Structural Organization of Complex Biomolecules?
Preview this section ↗
1.3a. Metabolites Are Used to Form the Building Blocks of Macromolecules ↗
1.3b. Organelles Represent a Higher Order in Biomolecular Organization ↗
1.3c. Membranes Are Supramolecular Assemblies That Define the Boundaries of Cells ↗
1.3d. The Unit of Life Is the Cell ↗
1.4
How Do the Properties of Biomolecules Reflect Their Fitness to the Living Condition?
Preview this section ↗
1.4a. Biological Macromolecules and Their Building Blocks Have a “Sense” or Directionality ↗
1.4b. Biological Macromolecules Are Informational ↗
1.4c. Biomolecules Have Characteristic Three-Dimensional Architecture ↗
1.4d. Weak Forces Maintain Biological Structure and Determine Biomolecular Interactions ↗
1.4e. Van Der Waals Forces Are Short-Range Interactions between Atoms in Nearby Molecules ↗
1.4f. Hydrogen Bonds Form between H Atoms and Electronegative Atoms Like N and O ↗
1.4g. Ionic Interactions Form between Oppositely Charged Groups or Molecules ↗
1.4h. Hydrophobic Interactions Are the Result of Favorable Interactions between Water Molecules ↗
1.4i. The Defining Concept of Biochemistry Is “Molecular Recognition through Structural Complementarity” ↗
1.4j. Biomolecular Recognition Is Mediated by Weak Chemical Forces ↗
1.4k. Weak Forces Restrict Organisms to a Narrow Range of Environmental Conditions ↗
1.4l. Enzymes Catalyze Metabolic Reactions ↗
1.4m. Biomolecular Phenomena across the Time Scale of Life ↗
1.5
What Are the Organization and Structure of Cells?
Preview this section ↗
1.5a. The Eukaryotic Cell Likely Emerged from an Archaeal Lineage ↗
1.5b. How Many Genes Does a Cell Need? ↗
1.5c. Archaea and Bacteria Have a Relatively Simple Structural Organization ↗
1.5d. The Structural Organization of Eukaryotic Cells Is More Complex Than That of Prokaryotic Cells ↗
1.6
What Are Viruses? ↗
Foundational Biochemistry ↗
Problems ↗
Further Reading ↗
Show more

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