Virus as Populations, 1st Edition

  • Esteban Domingo
  • Published By:
  • ISBN-10: 0128009942
  • ISBN-13: 9780128009949
  • DDC: 579.2
  • Grade Level Range: 11th Grade - College Senior
  • 428 Pages | eBook
  • Original Copyright 2015 | Published/Released March 2016
  • This publication's content originally published in print form: 2015

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This book explains fundamental concepts that arise from regarding viruses as complex populations when replicating in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, probability to be transmitted or response to treatment, depend on virus population numbers and in the variations of such population numbers.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
1: Introduction to Virus Origins and Their Role in Biological Evolution.
2: Molecular Basis of Genetic Variation of Viruses: Error-Prone Replication.
3: Darwinian Principles Acting on Highly Mutable Viruses.
4: Interaction of Virus Populations with Their Hosts.
5: Viral Fitness as a Measure of Adaptation.
6: Virus Population Dynamics Examined with Experimental Model Systems.
7: Long-Term Virus Evolution in Nature.
8: Quasispecies Dynamics in Disease Prevention and Control.
9: Trends in Antiviral Strategies.
10: Collective Population Effects in Nonviral Systems.
Further Reading.
Author Index.
Subject Index.