Developing Therapeutics for Alzheimer's Disease: Progress and Challenges, 1st Edition

  • Michael S. Wolfe
  • Published By:
  • ISBN-10: 0128021640
  • ISBN-13: 9780128021644
  • DDC: 616.831061
  • Grade Level Range: College Freshman - College Senior
  • 676 Pages | eBook
  • Original Copyright 2016 | Published/Released August 2016
  • This publication's content originally published in print form: 2016

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This compilation provides a thorough overview of the latest research and challenges associated with developing therapeutics for Alzheimer’s disease.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
List of Contributors.
1: The Complex Pathways to Mechanism-Based Therapeutics in Alzheimer's Disease.
2: The Genetic Basis of Alzheimer's Disease.
3: γ-Secretase Inhibition.
4: γ-Secretase Inhibitors: From Chemical Probes to Drug Development.
5: Therapeutic Targeting of Aβ42.
6: Modulators of Amyloid β-Protein (Aβ) Self-Assembly.
7: Anti-Amyloid-β Immunotherapy for Alzheimer's Disease.
8: Targeting Aβ Receptors to Modify Alzheimer's Disease Progression.
9: Blood–Brain Barrier Transport of Alzheimer's Amyloid β-Peptide.
10: Alzheimer's Disease Therapeutics Targeting Apolipoprotein E.
11: Microtubule Stabilization.
12: Tau Phosphorylation as a Therapeutic Target in Alzheimer's Disease.
13: Stimulation of Tau Degradation.
14: Passive Immunotherapy for Tau Pathology.
15: Inhibition of Tau Aggregation as a Basis for Treatment and Prevention of Alzheimer's Disease.
16: Neuroprotective Strategies for Alzheimer's Disease Prevention and Therapy.
17: Symptomatic Cognitive Enhancing Agents.
18: Tackling Alzheimer's Disease by Targeting Oxidative Stress and Mitochondria.
19: Clinical Issues in Alzheimer Drug Development.
20: Molecular Imaging in Alzheimer Clinical Trials.
21: Fluid Biomarkers and Diagnostics.
22: Nonpharmacologic Activity Interventions to Prevent Alzheimer's Disease.
23: Prospects and Challenges for Alzheimer Therapeutics.