eBook Neuropathology of Drug Addictions and Substance Misuse, Volume 1, 1st Edition

  • Volume 1
  • Victor Preedy
  • Published By:
  • ISBN-10: 0128003766
  • ISBN-13: 9780128003763
  • DDC: 616.86
  • Grade Level Range: College Freshman - College Senior
  • 1132 Pages | eBook
  • Original Copyright 2016 | Published/Released August 2016
  • This publication's content originally published in print form: 2016
  • Price:  Sign in for price



This title offers a modern approach on the pathology of substances of abuse, offering an evidence based ethos for understanding the neurology of addictions. Volume One focuses on tobacco, alcohol, cannabinoids, and opioids, with each section providing data on the general, molecular/cellular, and structural/functional neurological aspects of a given substance, along with a focus on the adverse consequences of addictions. The title is aimed at students and researchers of behavioral neuroscience, neurology, addiction science, psychology, and research psychiatry.

Table of Contents

Front Cover.
Half Title Page.
Other Frontmatter.
Title Page.
Copyright Page.
List of Contributors.
Setting the Scene: Foundations for Understanding Substance Misuse and Their Effects.
1: The Nervous System and Addictions: Essentials for Clinicians.
2: Pathophysiology-Based Neuromodulation for Addictions: An Overview.
3: Gateway Hypothesis of Addiction and Substance Misuse: The Role of Neurophysiology and Psychological Mechanisms.
4: Children of Parents with Substance Use Disorder.
5: Drugs of Abuse and the Internet.
6: Trauma and Neurological Risks of Addiction.
7: Emotional Self-Medication and Addiction.
8: The Neurobiology of Comorbid Drug Abuse in Schizophrenia and Psychotic Disorders.
Tobacco: Section A: General Aspects.
9: Nicotine Chemistry, Pharmacology, and Pharmacokinetics.
10: Tobacco-Related Mortality among Individuals with Alcohol or Drug Use Disorders.
11: Neurological Effects of Nicotine, Tobacco, and Particulate Matter.
Tobacco: Section B: Molecular and Cellular Aspects.
12: Rho GTPases and Their Regulators in Addiction: A Focus on the Association of a β2-Chimaerin Polymorphism with Smoking.
13: Brain Orexin Receptors and Nicotine.
14: Nicotine and Stimulatory Effects on 5-HT DRN Neurons.
15: Critical Role of Cannabinoid CB1 Receptors in Nicotine Reward and Addiction.
16: Targets of Addictive Nicotine in the Central Nervous System and Interactions with Alcohol.
17: Cytochrome P450 and Oxidative Stress as Possible Pathways for Alcohol- and Tobacco-Mediated HIV Pathogenesis and NeuroAIDS.
18: Nicotine and Neurokinin Signaling.
19: Neurotransmitter Systems and the Nicotine Dependence-Induced Withdrawal Syndrome: Dopamine, Glutamate, GABA, Endogenous Opioids, Endocannabinoids, Noradrenaline, Arginine Vasopressin, Neuropeptide Y, MAO, CREB, and Corticotropin-Releasing Factor.
20: Genetic Findings on the Relationship between Smoking and the Stress System.
21: Genetic Variants of μ Opioid Receptor and Its Interacting Proteins in Smoking: A Focus on OPRM1 A118G, ARRB2, and HINT1.
Tobacco: Section C: Structural and Functional Aspects.
22: Characterization of Cue-Induced Reinstatement of Nicotine-Seeking Behavior in Smoking Relapse: Use of Animal Models.
23: Effects of Environmental Enrichment on Nicotine Addiction.
24: Smokers with Severe Mental Illness.
25: Nicotine Dependence and Schizophrenia.
26: Unraveling the Role of the Amygdala in Nicotine Addiction.
27: Nicotine and Cognition: Effects of Nicotine on Attention and Memory Systems in Humans.
28: The Role of Appetitive and Aversive Smoking Cues in Tobacco Use Disorder with a Focus on fMRI.
29: Different Effects of Cigarette Smoking on Neuropsychological Performance in Psychiatric Disorders.
30: Tobacco Smoke Extract-Produced Behavioral Effects: Locomotor Sensitization and Self-Administration Studies.
31: The Psychological Threat of Mortality and Its Implications for Tobacco and Alcohol Misuse.
32: Nicotine Dependence and the Anterior Cingulate-Precuneus Pathway: Using Neuroimaging to Test Addiction Theories.
33: Neural Effects of Nicotine: Peripheral Sensory Systems and Experience-Dependent Neural Sensitization.
Tobacco: Section D: Methods.
34: Cotinine Urinalysis for Tobacco Use.
Alcohol: Section A: General Aspects.
35: Ethanol Metabolism and Implications for Disease.
36: Heavy Episodic Drinking or Binge Drinking: A Booming Consumption Pattern.
Alcohol: Section B: Molecular and Cellular Aspects.
37: Alcohol and Endogenous Opioids.
38: Effects of Alcohol on Nicotinic Acetylcholine Receptors and Impact on Addiction.
39: Alcohol and Its Impact on Myelin.
40: The Effects of Acute and Chronic Ethanol Exposure on GABAergic Neuroactive Steroid Immunohistochemistry: Relationship to Ethanol Drinking.
41: Ethanol and Its Impact on the Brain's Electrical Activity.
42: Alcohol and Neuroimmune Interactions.
43: Role of Glutamate Transport in Alcohol Withdrawal.
44: Ethanol, Vitamins, and Brain Dysfunction.
45: Phospholipase D: A Central Switch in the Development of Fetal Alcohol Spectrum Disorder.
46: N-Methyl-D-Aspartate Receptor Subunits and Alcohol.
47: Alcohol Dehydrogenase Alleles and Impact on Neuropathology.
48: ADH Cluster Genes, Genome-Wide Association Studies, and Alcohol Dependence.
49: Neuropathology of Gene Expression during Alcohol Withdrawal.
50: The Quest of Candidate Gene in Alcohol Dependence: The Dopamine D2 Receptor (DRD2) Gene.
51: Acetaldehyde: A Reactive Metabolite.
Alcohol: Section C: Structural and Functional Aspects.
52: Cortical Morphology in Fetal Alcohol Spectrum Disorders: Insights from Computational Neuroimaging.
53: Abnormalities of Cerebellar Structure and Function in Alcoholism and Other Substance Use Disorders.
54: Brain Volumes in Adolescents with Alcohol Use Disorder.
55: Central Pontine Myelinolysis in Alcoholism: An Osmotic Demyelination Syndrome.
56: The Role of Brain Glucocorticoid Systems in Alcohol Dependence.
57: Neuropathobiology of Alcohol-Induced Cognitive Deficits.
58: Neuropathology in Neuropsychiatric Disorders Secondary to Alcohol Misuse.
59: Social Isolation and Ethanol Drinking: A Preclinical Model of Addiction Vulnerability in Males, but Not Females.
Alcohol: Section D: Methods.
60: The Ultrarapid Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST-Lite) and Implications for Neuropathology.
Cannabinoids: Section A: General Aspects.
61: Overview of Cannabis Use, Misuse, and Addiction.
62: An Overview of Major and Minor Phytocannabinoids.
63: Treating the Phenomenon of New Psychoactive Substances: Synthetic Cannabinoids and Synthetic Cathinones.
Cannabinoids: Section B: Molecular and Cellular Aspects.
64: Role of Lipid Rafts and the Underlying Filamentous-Actin Cytoskeleton in Cannabinoid Receptor 1 Signaling.
65: Cannabinoid Agonists.
66: Molecular Pharmacology of CB1 and CB2 Cannabinoid Receptors.
67: Does Agonist Efficacy Alter the In Vivo Effects of Cannabinoids: Girl, Could We Get Much “Higher”?.
68: Cannabis, Cannabinoid Receptors, and Stress-Induced Excitotoxicity.
69: Cannabis, Endocannabinoid CB1 Receptors, and the Neuropathology of Vision.
70: Cannabidiol and 5-HT1A Receptors.
71: CB1 Receptor-Mediated Signaling Mechanisms in the Deleterious Effects of Spice Abuse.
Cannabinoids: Section C: Structural and Functional Aspects.
72: Cannabis Use Disorders and Brain Morphology.
73: Imaging Dopamine Alterations in Cannabis Dependence.
74: Cannabis and the Mesolimbic System.
75: Role of the Endocannabinoid System and Major Cannabis Constituents in the Reconsolidation and Extinction of Rewarding Drug-Associated Memories.
76: Effects of Δ9-Tetrahydrocannabinol, Synthetic Cannabinoids, and Fatty Acid Amide Hydrolase Inhibitors on Mood and Serotonin Neurotransmission.
77: CB1 Cannabinoid Receptors and Aggression: Relationship to Cannabis Use.
78: Cannabis and Bipolar Manic Episodes.
79: White Matter, Schizophrenia, and Cannabis.
80: Electroencephalography and Cannabis: From Event-Related Potentials to Oscillations.
Opioids: Section A: General Aspects.
81: Street Level Heroin, an Overview on Its Components and Adulterants.
82: Opioid Prescription Drug Abuse and Its Relation to Heroin Trends.
Opioids: Section B: Molecular and Cellular Aspects.
83: Corticotropin-Releasing Factor Signaling at the Intersection of Pain and Opioid Addiction.
84: The Role of the δ Opioid Receptor Gene, OPRD1, in Addiction.
85: Genome-Wide Association Studies and Human Opioid Sensitivity.
86: Opiate Receptors and Gender and Relevance to Heroin Addiction.
87: Transcriptional Effects of Heroin and Methamphetamine in the Striatum.
Opioids: Section C: Structural and Functional Aspects.
88: Neurological Abnormalities in Opiate Addicts.
89: Clinical and Preclinical Molecular Imaging in Chronic Pain-Implications for Analgesic Use and Misuse.
90: Single-Photon-Emission Computed Tomography Studies with Dopamine and Serotonin Transporters in Opioid Users.
91: Personality Dimensions, Impulsivity, and Heroin.
92: fMRI of Heroin and Ketamine Addiction.
93: Heroin-Induced Cerebrovascular Ischemia and Leukoencephalopathy: Role of Mitochondria.
94: The Hypothalamic-Pituitary-Adrenal Axis and Related Brain Stress-Response Systems and Heroin.
95: Accelerated Aging in Heroin Abusers: Readdressing a Clinical Anecdote Using Telomerase and Neuroimaging.
96: Attention Deficit Hyperactivity Disorder, Substance Use Disorders, and Heroin Addiction.
97: Impaired Cognition Control and Inferior Frontal Cortex Modulation in Heroin Addiction.
Opioids: Section D: Methods.
98: Assay for Opium Alkaloids.
99: Features of the Tridimensional Personality Questionnaire Associated with Heroin Users.
100: Index.