Half Title Page.
List of Contributors.
Setting the Scene: Foundations for Understanding Substance Misuse and Their Effects.
1: The Nervous System and Addictions: Essentials for Clinicians.
2: Pathophysiology-Based Neuromodulation for Addictions: An Overview.
3: Gateway Hypothesis of Addiction and Substance Misuse: The Role of Neurophysiology and Psychological Mechanisms.
4: Children of Parents with Substance Use Disorder.
5: Drugs of Abuse and the Internet.
6: Trauma and Neurological Risks of Addiction.
7: Emotional Self-Medication and Addiction.
8: The Neurobiology of Comorbid Drug Abuse in Schizophrenia and Psychotic Disorders.
Tobacco: Section A: General Aspects.
9: Nicotine Chemistry, Pharmacology, and Pharmacokinetics.
10: Tobacco-Related Mortality among Individuals with Alcohol or Drug Use Disorders.
11: Neurological Effects of Nicotine, Tobacco, and Particulate Matter.
Tobacco: Section B: Molecular and Cellular Aspects.
12: Rho GTPases and Their Regulators in Addiction: A Focus on the Association of a β2-Chimaerin Polymorphism with Smoking.
13: Brain Orexin Receptors and Nicotine.
14: Nicotine and Stimulatory Effects on 5-HT DRN Neurons.
15: Critical Role of Cannabinoid CB1 Receptors in Nicotine Reward and Addiction.
16: Targets of Addictive Nicotine in the Central Nervous System and Interactions with Alcohol.
17: Cytochrome P450 and Oxidative Stress as Possible Pathways for Alcohol- and Tobacco-Mediated HIV Pathogenesis and NeuroAIDS.
18: Nicotine and Neurokinin Signaling.
19: Neurotransmitter Systems and the Nicotine Dependence-Induced Withdrawal Syndrome: Dopamine, Glutamate, GABA, Endogenous Opioids, Endocannabinoids, Noradrenaline, Arginine Vasopressin, Neuropeptide Y, MAO, CREB, and Corticotropin-Releasing Factor.
20: Genetic Findings on the Relationship between Smoking and the Stress System.
21: Genetic Variants of μ Opioid Receptor and Its Interacting Proteins in Smoking: A Focus on OPRM1 A118G, ARRB2, and HINT1.
Tobacco: Section C: Structural and Functional Aspects.
22: Characterization of Cue-Induced Reinstatement of Nicotine-Seeking Behavior in Smoking Relapse: Use of Animal Models.
23: Effects of Environmental Enrichment on Nicotine Addiction.
24: Smokers with Severe Mental Illness.
25: Nicotine Dependence and Schizophrenia.
26: Unraveling the Role of the Amygdala in Nicotine Addiction.
27: Nicotine and Cognition: Effects of Nicotine on Attention and Memory Systems in Humans.
28: The Role of Appetitive and Aversive Smoking Cues in Tobacco Use Disorder with a Focus on fMRI.
29: Different Effects of Cigarette Smoking on Neuropsychological Performance in Psychiatric Disorders.
30: Tobacco Smoke Extract-Produced Behavioral Effects: Locomotor Sensitization and Self-Administration Studies.
31: The Psychological Threat of Mortality and Its Implications for Tobacco and Alcohol Misuse.
32: Nicotine Dependence and the Anterior Cingulate-Precuneus Pathway: Using Neuroimaging to Test Addiction Theories.
33: Neural Effects of Nicotine: Peripheral Sensory Systems and Experience-Dependent Neural Sensitization.
Tobacco: Section D: Methods.
34: Cotinine Urinalysis for Tobacco Use.
Alcohol: Section A: General Aspects.
35: Ethanol Metabolism and Implications for Disease.
36: Heavy Episodic Drinking or Binge Drinking: A Booming Consumption Pattern.
Alcohol: Section B: Molecular and Cellular Aspects.
37: Alcohol and Endogenous Opioids.
38: Effects of Alcohol on Nicotinic Acetylcholine Receptors and Impact on Addiction.
39: Alcohol and Its Impact on Myelin.
40: The Effects of Acute and Chronic Ethanol Exposure on GABAergic Neuroactive Steroid Immunohistochemistry: Relationship to Ethanol Drinking.
41: Ethanol and Its Impact on the Brain's Electrical Activity.
42: Alcohol and Neuroimmune Interactions.
43: Role of Glutamate Transport in Alcohol Withdrawal.
44: Ethanol, Vitamins, and Brain Dysfunction.
45: Phospholipase D: A Central Switch in the Development of Fetal Alcohol Spectrum Disorder.
46: N-Methyl-D-Aspartate Receptor Subunits and Alcohol.
47: Alcohol Dehydrogenase Alleles and Impact on Neuropathology.
48: ADH Cluster Genes, Genome-Wide Association Studies, and Alcohol Dependence.
49: Neuropathology of Gene Expression during Alcohol Withdrawal.
50: The Quest of Candidate Gene in Alcohol Dependence: The Dopamine D2 Receptor (DRD2) Gene.
51: Acetaldehyde: A Reactive Metabolite.
Alcohol: Section C: Structural and Functional Aspects.
52: Cortical Morphology in Fetal Alcohol Spectrum Disorders: Insights from Computational Neuroimaging.
53: Abnormalities of Cerebellar Structure and Function in Alcoholism and Other Substance Use Disorders.
54: Brain Volumes in Adolescents with Alcohol Use Disorder.
55: Central Pontine Myelinolysis in Alcoholism: An Osmotic Demyelination Syndrome.
56: The Role of Brain Glucocorticoid Systems in Alcohol Dependence.
57: Neuropathobiology of Alcohol-Induced Cognitive Deficits.
58: Neuropathology in Neuropsychiatric Disorders Secondary to Alcohol Misuse.
59: Social Isolation and Ethanol Drinking: A Preclinical Model of Addiction Vulnerability in Males, but Not Females.
Alcohol: Section D: Methods.
60: The Ultrarapid Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST-Lite) and Implications for Neuropathology.
Cannabinoids: Section A: General Aspects.
61: Overview of Cannabis Use, Misuse, and Addiction.
62: An Overview of Major and Minor Phytocannabinoids.
63: Treating the Phenomenon of New Psychoactive Substances: Synthetic Cannabinoids and Synthetic Cathinones.
Cannabinoids: Section B: Molecular and Cellular Aspects.
64: Role of Lipid Rafts and the Underlying Filamentous-Actin Cytoskeleton in Cannabinoid Receptor 1 Signaling.
65: Cannabinoid Agonists.
66: Molecular Pharmacology of CB1 and CB2 Cannabinoid Receptors.
67: Does Agonist Efficacy Alter the In Vivo Effects of Cannabinoids: Girl, Could We Get Much “Higher”?.
68: Cannabis, Cannabinoid Receptors, and Stress-Induced Excitotoxicity.
69: Cannabis, Endocannabinoid CB1 Receptors, and the Neuropathology of Vision.
70: Cannabidiol and 5-HT1A Receptors.
71: CB1 Receptor-Mediated Signaling Mechanisms in the Deleterious Effects of Spice Abuse.
Cannabinoids: Section C: Structural and Functional Aspects.
72: Cannabis Use Disorders and Brain Morphology.
73: Imaging Dopamine Alterations in Cannabis Dependence.
74: Cannabis and the Mesolimbic System.
75: Role of the Endocannabinoid System and Major Cannabis Constituents in the Reconsolidation and Extinction of Rewarding Drug-Associated Memories.
76: Effects of Δ9-Tetrahydrocannabinol, Synthetic Cannabinoids, and Fatty Acid Amide Hydrolase Inhibitors on Mood and Serotonin Neurotransmission.
77: CB1 Cannabinoid Receptors and Aggression: Relationship to Cannabis Use.
78: Cannabis and Bipolar Manic Episodes.
79: White Matter, Schizophrenia, and Cannabis.
80: Electroencephalography and Cannabis: From Event-Related Potentials to Oscillations.
Opioids: Section A: General Aspects.
81: Street Level Heroin, an Overview on Its Components and Adulterants.
82: Opioid Prescription Drug Abuse and Its Relation to Heroin Trends.
Opioids: Section B: Molecular and Cellular Aspects.
83: Corticotropin-Releasing Factor Signaling at the Intersection of Pain and Opioid Addiction.
84: The Role of the δ Opioid Receptor Gene, OPRD1, in Addiction.
85: Genome-Wide Association Studies and Human Opioid Sensitivity.
86: Opiate Receptors and Gender and Relevance to Heroin Addiction.
87: Transcriptional Effects of Heroin and Methamphetamine in the Striatum.
Opioids: Section C: Structural and Functional Aspects.
88: Neurological Abnormalities in Opiate Addicts.
89: Clinical and Preclinical Molecular Imaging in Chronic Pain-Implications for Analgesic Use and Misuse.
90: Single-Photon-Emission Computed Tomography Studies with Dopamine and Serotonin Transporters in Opioid Users.
91: Personality Dimensions, Impulsivity, and Heroin.
92: fMRI of Heroin and Ketamine Addiction.
93: Heroin-Induced Cerebrovascular Ischemia and Leukoencephalopathy: Role of Mitochondria.
94: The Hypothalamic-Pituitary-Adrenal Axis and Related Brain Stress-Response Systems and Heroin.
95: Accelerated Aging in Heroin Abusers: Readdressing a Clinical Anecdote Using Telomerase and Neuroimaging.
96: Attention Deficit Hyperactivity Disorder, Substance Use Disorders, and Heroin Addiction.
97: Impaired Cognition Control and Inferior Frontal Cortex Modulation in Heroin Addiction.
Opioids: Section D: Methods.
98: Assay for Opium Alkaloids.
99: Features of the Tridimensional Personality Questionnaire Associated with Heroin Users.