eBook Developing Therapeutics for Alzheimer's Disease: Progress and Challenges, 1st Edition

  • Michael S. Wolfe
  • Published By:
  • ISBN-10: 0128021640
  • ISBN-13: 9780128021644
  • DDC: 616.831061
  • Grade Level Range: College Freshman - College Senior
  • 676 Pages | eBook
  • Original Copyright 2016 | Published/Released August 2016
  • This publication's content originally published in print form: 2016
  • Price:  Sign in for price

About

Overview

This compilation provides a thorough overview of the latest research and challenges associated with developing therapeutics for Alzheimer’s disease.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Dedication.
Contents.
List of Contributors.
Foreword.
Preface.
1: The Complex Pathways to Mechanism-Based Therapeutics in Alzheimer's Disease.
2: The Genetic Basis of Alzheimer's Disease.
3: γ-Secretase Inhibition.
4: γ-Secretase Inhibitors: From Chemical Probes to Drug Development.
5: Therapeutic Targeting of Aβ42.
6: Modulators of Amyloid β-Protein (Aβ) Self-Assembly.
7: Anti-Amyloid-β Immunotherapy for Alzheimer's Disease.
8: Targeting Aβ Receptors to Modify Alzheimer's Disease Progression.
9: Blood–Brain Barrier Transport of Alzheimer's Amyloid β-Peptide.
10: Alzheimer's Disease Therapeutics Targeting Apolipoprotein E.
11: Microtubule Stabilization.
12: Tau Phosphorylation as a Therapeutic Target in Alzheimer's Disease.
13: Stimulation of Tau Degradation.
14: Passive Immunotherapy for Tau Pathology.
15: Inhibition of Tau Aggregation as a Basis for Treatment and Prevention of Alzheimer's Disease.
16: Neuroprotective Strategies for Alzheimer's Disease Prevention and Therapy.
17: Symptomatic Cognitive Enhancing Agents.
18: Tackling Alzheimer's Disease by Targeting Oxidative Stress and Mitochondria.
19: Clinical Issues in Alzheimer Drug Development.
20: Molecular Imaging in Alzheimer Clinical Trials.
21: Fluid Biomarkers and Diagnostics.
22: Nonpharmacologic Activity Interventions to Prevent Alzheimer's Disease.
23: Prospects and Challenges for Alzheimer Therapeutics.
Index.