eBook Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, 1st Edition

  • Volume 12
  • M. Hayat
  • Published By:
  • ISBN-10: 0128121475
  • ISBN-13: 9780128121474
  • DDC: 571.6
  • Grade Level Range: College Freshman - College Senior
  • 622 Pages | eBook
  • Original Copyright 2017 | Published/Released April 2018
  • This publication's content originally published in print form: 2017
  • Price:  Sign in for price



This volume discusses and details almost all aspects of the autophagy machinery in the context of health, cancer and other pathologies. Autophagy is more widely accepted as beneficial given its role in eliminating ‘toxic assets’ and promoting cell viability, hence, it has emerged as a new and potent modulator of disease progression that is both scientifically intriguing and clinically relevant. As the latest release in the Autophagy book series, users will find a detailed explanation of the role of molecular mechanisms.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Knowing Autophagy.
10 Lines of Autophagy for Volume 10.
Mitophagy and Biogenesis.
Autophagy and Cancer.
Some Thoughts on Autophagy and Immunity.
Autophagy: Friend or Foe?.
Autophagy: If and When.
What Happened When Autophagy Didn’t.
Sugar Isn’t Always Sweet.
Mitochondrial Mysteries.
A Photo Is Static, An Instant in Time.
Autophagy Subversion.
An Autophagy a Day.
Autophagy: Volume 1—Contributions.
Autophagy: Volume 2—Contributions.
Autophagy: Volume 3—Contributions.
Autophagy: Volume 4—Contributions.
Autophagy: Volume 5—Contributions.
Autophagy: Volume 6—Contributions.
Autophagy: Volume 7—Contributions.
Autophagy: Volume 8—Contributions.
Autophagy: Volume 9—Contributions.
Autophagy: Volume 10—Contributions.
Autophagy: Volume 11—Contributions.
1: Overview of Autophagy.
2: The Role of Autophagy in Aging: Molecular Mechanisms.
3: The Role of p62 in Aggregopathies.
4: Role of Autophagy in the Transition From Monocyte to Differentiation.
5: Cdc48 AAA ATPase Regulates Protein Dynamics and Turnover in Mitochondria.
6: Autophagy in Plasma Cells.
7: Loss of PINK1 or Parkin Function Results in a Progressive Loss of Mitochondrial Function.
8: Role of the Transcription Factor Interferon Regulatory Factor-1 in Regulating Autophagy in Lipopolysaccharide-Stimulated Macrophages.
9: Mechanistic Target of Rapamycin: The Alpha and Omega of Autophagy Regulation.
10: ER-Phagy in Starvation, ER Stress, and Quality Control.
11: Role of Autophagy Inhibition in Tumor Proliferative Arrest.
12: Survival at the Brink: Chromatin Autophagy of Tumor Cells in Response to Genotoxic Challenge.
13: Loss of Autophagy in Hypothalamic Neurons May Be Involved in the Pathogenesis of Obesity.
14: Defective Autophagy in Mesenteric Fat Tissue Maintains Inflammation in Crohn’s Disease.
15: Autophagy Regulates Inflammatory Responses in Antigen-Presenting Cells: Underlying Mechanisms.
16: Autophagy Accompanies Inflammasome Activation to Moderate Inflammation by Eliminating Active Inflammasomes.
17: Autophagy, Inflammation, and Breast Cancer Risk.
18: AMBRA1-Mediated Regulation of C-MYC and Its Relevance to Cancer.
19: The Delicate Balance of Autophagy in Neurodegeneration.
20: Silibinin Protects Ultraviolet B–Irradiated Skin by Balancing Apoptosis and Autophagy in Epidermis and Dermis.
21: Role of Autophagy Activation in Alleviating Alcohol Neurotoxicity.
22: Lipopolysaccharide-Enhanced Bactericidal Activity is Mediated by Induction of the Autophagosomal Process.
23: Role of Autophagy in Liver Regeneration.
24: A Dual Role of a Soluble N-Ethylmaleimide Sensitive Factor–Attachment Protein Alpha (αSNAP) in the Regulation of Autophagy.
25: Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Induces Autophagic Protein Cleavage in Melanoma Cells.
Abbreviations and Glossary.