Diabetic Cardiomyopathy, 1st Edition

  • Published By:
  • ISBN-10: 146149317X
  • ISBN-13: 9781461493174
  • DDC: 616.12407
  • Grade Level Range: College Freshman - College Senior
  • 416 Pages | eBook
  • Original Copyright 2014 | Published/Released August 2014
  • This publication's content originally published in print form: 2014

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Diabetes has long been recognized as a disease of high blood sugar, and there has been a continuous search for the reason for its development and effective treatment. In 2005, the World Health Organization estimated that more than 180 million people worldwide suffer from diabetes mellitus and indicated this figure is likely to double within the next 20 years. Among the 3.8 million diabetes-related deaths each year, about two thirds are attributable to cardiovascular complications, and diabetes is now considered to be a major metabolic risk factor for heart disease. This book compiles review articles relating to biochemical and molecular mechanisms of hyperglycaemia. Topics are of interest to basic research scientists, clinicians and graduate students, studying the pathogenesis of diabetes-induced cardiovascular dysfunction. Some chapters are directed toward enhancing our understanding of novel ways for the prevention/treatment of cardiomyopathy.Twenty-five articles are organized in three sections. The first section covers general aspects of the metabolic derangements in diabetic cardiomyopathy, including metabolic alterations and substrate utilization, as well as cardiac remodeling in the heart; role of diet in the development of metabolic syndrome in the heart; effect of hyperglycaemia in terms of biochemical and structural alterations in heart. The second section covers cellular and molecular mechanisms indicating that diabetic cardiomyopathy is a multifactorial and complex problem. The third section discusses the prevention and treatment of diabetes using appropriate diet, proper supplements including antioxidants, angiotensin inhibitors and other drugs. The book discusses diverse mechanisms of diabetic cardiomyopathy with information on new therapeutic approaches for finding solutions to prevent or reverse the development of cardiac dysfunction.

Table of Contents

Front Cover.
Other Frontmatter.
Title Page.
Copyright Page.
Dedication Page.
1: Metabolic Derangements in Diabetic Cardiomyopathy.
2: Metabolic Alterations in Diabetic Cardiomyopathy.
3: Metabolic and Contractile Remodelling in the Diabetic Heart: An Evolutionary Perspective.
4: Induction of Metabolic Syndrome by Excess Fructose Consumption.
5: Substrate Metabolism in the Diabetic Heart.
6: Effects of Diabetes-Induced Hyperglycemia in the Heart: Biochemical and Structural Alterations.
7: Hyperglycemia, Oxidative Stress, and Vascular Complications: Role of Epigenetic Mechanisms.
8: A Critical Balance Between Oxidative Stress and Antioxidant Defense in Cardiovascular System Under Hyperglycemia: A Summary of Experimental Studies.
9: Aldose Reductase and Diabetic Cardiovascular Disease.
10: Sex Differences and Diabetes Mellitus in Cardiovascular Function.
11: Cellular Mechanisms of Diabetic Cardiomyopathy.
12: MicroRNomics of Diabetic Cardiomyopathy.
13: Cellular Mechanism Underlying the Misfunction of Cardiac Ionic Channels in Diabetes.
14: Role of PPAR-δ in Diabetic Cardiomyopathy.
15: The Role of Inflammation in Type 2 Diabetes-Driven Atherosclerosis.
16: Cardiovascular Autonomic Neuropathy in Diabetes.
17: Liver and Fat in Type 2 Diabetes: New Insights and Clinical Relevance.
18: Roles of PKC Isoforms in Development of Diabetes-Induced Cardiovascular Complications.
19: Calcium-Handling Proteins in Diabetic Cardiomyopathy.
20: Abnormalities in ATP Production and Utilization in Diabetic Cardiomyopathy.
21: Therapeutic Aspects of Diabetic Cardiomyopathy.
22: The Next Generation of Diagnostic Biomarkers for Type 2 Diabetes.
23: PDE-5 Inhibitors in Protection of Diabetic Heart.
24: Restoration of Angiogenesis: A Promising Therapeutic Strategy in Diabetic Cardiomyopathy.
25: The Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas Receptor Axis: A Potential Target for Treating Diabetic Cardiovascular Disease.
26: Targeting Matrix Metalloproteinase 2 and 9 for Treatment of Cardiovascular Dysfunction of Diabetes.
27: Nutraceutical Approaches in the Management of Cardiovascular Dysfunctions Associated with Diabetes Mellitus.
28: Nutritional Management of Cardiovascular Complications Caused by Diabetes.