New Models of the Cell Nucleus: Crowding, Entropic Forces, Phase Separation, and Fractals, 1st Edition

  • Published By:
  • ISBN-10: 0128002522
  • ISBN-13: 9780128002520
  • DDC: 571.66
  • Grade Level Range: College Freshman - College Senior
  • 512 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013

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International Review of CellĀ and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2012: 4.973. Ideas from the fields of biophysics, physical chemistry, of polymer and colloid, and soft matter science have helped clarify the structure and functions of the cell nucleus. The development of powerful methods for modeling conformations and interactions of macromolecules has also contributed. The book aims to encourage cell and molecular biologists to become more familiar with and understand these new concepts and methods, and the crucial contributions they are making to our perception of the nucleus. This is the first volume to present a comprehensive review of New Models of the Cell Nucleus.

Table of Contents

Front Cover.
Half Title Page.
Other Frontmatter.
Title Page.
Copyright Page.
1: The Nuclear Physique.
2: The Crowded Nucleus.
3: Crowding in Polymer–Nanoparticle Mixtures.
4: Crowding-Induced Formation and Structural Alteration of Nuclear Compartments: Insights from Computer Simulations.
5: Phase Separation as a Possible Means of Nuclear Compartmentalization.
6: Formation of Multiprotein Assemblies in the Nucleus: The Spindle Assembly Checkpoint.
7: Characteristic Behavior of Crowding Macromolecules Confined in Cell-Sized Droplets.
8: Noncanonical Structures and Their Thermodynamics of DNA and RNA under Molecular Crowding.
9: Computational Models of Large-Scale Genome Architecture.
10: How Chromatin Looping and Nuclear Envelope Attachment Affect Genome Organization in Eukaryotic Cell Nuclei.
11: Crowding, Diffusion, and Biochemical Reactions.
12: Importance of Crowding in Signaling, Genetic, and Metabolic Networks.
13: Relevance and Limitations of Crowding, Fractal, and Polymer Models to Describe Nuclear Architecture.