Toxicogenomics-Based Cellular Models, 1st Edition

  • Published By:
  • ISBN-10: 0123978718
  • ISBN-13: 9780123978714
  • DDC: 615.907
  • Grade Level Range: College Freshman - College Senior
  • 362 Pages | eBook
  • Original Copyright 2013 | Published/Released May 2014
  • This publication's content originally published in print form: 2013

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Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well as opportunities and challenges for the future. Written by renowned international toxicological experts, this book explores ‘omics technology for developing new assays for toxicity testing and safety assessment and provides the reader with a focused examination of alternative means to animal testing.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
List of Contributors.
1: Introduction to Toxicogenomics-Based Cellular Models.
2: Introduction to Toxicogenomics-Based Cellular Models.
3: Genotoxicity and Carcinogenesis.
4: Application of in vivo Genomics to the Prediction of Chemical-Induced (hepato) Carcinogenesis.
5: Unraveling the DNA Damage Response Signaling Network through RNA Interference Screening.
6: Immunotoxicity.
7: Immunotoxicity Testing: Implementation of Mechanistic Understanding, Key Pathways of Toxicological Concern, and Components of These Pathways.
8: Chemical Sensitization.
9: 'Omics-Based Testing for Direct Immunotoxicity.
10: Reproduction Toxicity.
11: Implementation of Transcriptomics in the Zebrafish Embryotoxicity Test.
12: Transcriptomic Approaches in in vitro Developmental Toxicity Testing.
13: Thyroid Toxicogenomics: A Multi-Organ Paradigm.
14: Organ Toxicity.
15: Hepatotoxicity Screening on in vitro Models and the Role of 'Omics.
16: An Overview of Toxicogenomics Approaches to Mechanistically Understand and Predict Kidney Toxicity.
17: 'Omics in Organ Toxicity, Integrative Analysis Approaches, and Knowledge Generation.
18: Hepatotoxicity and the Circadian Clock: A Timely Matter.
19: Toxicoinformatics.
20: Introduction to Toxicoinformatics.
21: Toxicogenomics and Systems Toxicology Databases and Resources: Chemical Effects in Biological Systems (CEBS) and Data Integration by Applying Models on Design and Safety (DIAMONDS).
22: Bioinformatics Methods for Interpreting Toxicogenomics Data: The Role of Text-Mining.
23: Selection and Validation of Toxicogenomics Assays as Alternatives to Animal Tests.
24: Selection and Validation of Toxicogenomics Assays as Alternatives to Animal Tests.
25: Toxicogenomics Implementation Strategies.
26: Toxicogenomics Implementation Strategies.