Autoantibodies, 3rd Edition

  • Published By:
  • ISBN-10: 0444593772
  • ISBN-13: 9780444593771
  • DDC: 616.978
  • Grade Level Range: College Freshman - College Senior
  • 916 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013

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Autoimmune diseases are characterized by the occurrence of antibodies reacting with self-constituents of the body. The fully updated third edition of Autoantibodies is an in-depth review of the main autoantibodies identified up to now, with particular emphasis on those that display a diagnostic or prognostic clinical value. The new edition covers recent scientific advances, diagnostic techniques, and therapeutic technologies. Each chapter is focused on a single family of autoantibodies. This important reference contains historical notes, definitions, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value). This is an ideal reference for anyone involved in the field of autoimmune diseases.

Table of Contents

Front Cover.
Half Title Page.
Other Frontmatter.
Title Page.
Copyright Page.
Dedication Page.
Cover Image Credits.
List of Contributors.
1: Foreword – The Concept of Immunodiagnosis.
2: The Concept of Immunodiagnosis.
3: Introduction: Autoantibodies-Unique Characteristics.
4: What is an Autoantibody?.
5: Natural Autoantibodies—Homeostasis, Autoimmunity, and Therapeutic Potential.
6: Molecular Mimicry.
7: Affinity and Avidity of Autoantibodies.
8: Pathogenic Mechanisms and Clinical Relevance of Autoantibodies.
9: Predictive Autoantibodies.
10: Antibodies against Acute Phase Proteins.
11: Idiotypes and Anti-Idiotypes.
12: Introductory Remarks for the Diagnostic and Therapeutic Applications of Monoclonal Antibodies and Various Formats.
13: Allergic Disease Autoantibodies.
14: Human Autoantibodies in Urticaria, Angioedema, and Other Atopic Diseases.
15: Antineutrophil Antibodies.
16: Antineutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase.
17: Antineutrophil Cytoplasmic Antibodies with Specificity for Proteinase 3.
18: Neutrophil-Specific Antinuclear and Anticytoplasmic Autoantibodies in Chronic Inflammatory Diseases.
19: Introduction: Antinuclear Antibodies.
20: Antinuclear Antibodies: General Introduction.
21: Autoantibodies to Survival of Motor Neuron (SMN) Complex.
22: Antinucleolar Antibodies as Diagnostic Markers in Systemic Autoimmune Diseases.
23: Anti-U1RNP and -Sm Antibodies.
24: Antibodies to Rods and Rings.
25: Antinucleosome Autoantibodies.
26: Centromere Autoantibodies.
27: dsDNA Autoantibodies.
28: Histone Autoantibodies.
29: Ku and Ki Autoantibodies.
30: Neuronal Nuclear Autoantibodies, Type 1 (Hu).
31: Nuclear Envelope Protein Autoantibodies/Antilamin Autoantibodies.
32: Antiribosomal P Antibodies.
33: Ro/SSA Autoantibodies.
34: Topoisomerase I (SCL 70) Autoantibodies.
35: SS-B (La) Autoantibodies.
36: Autoantibodies to Biologic Factors/Structures.
37: Autoantibodies to GW/P Bodies and Components of the MicroRNA Pathway.
38: Golgi Complex and Endosome Antibodies.
39: Tumor-Associated Autoantibodies.
40: p53 Autoantibodies.
41: Naturally Occurring Anti-HLA-E Autoantibodies: Evidences of HLA-Ia Reactivity of Anti-HLA-E Antibodies.
42: Autoantibodies in Therapeutic Preparations of Human Intravenous Immunoglobulin (IVIg).
43: Cytoskeletal Autoantibodies/Antiactin Antibodies.
44: Fibrillarin Autoantibodies.
45: Fibronectin Autoantibodies.
46: IFI16 Autoantibodies.
47: Cardiac Autoantibodies.
48: Heat Shock Protein Autoantibodies.
49: Antimyocardial Autoantibodies (AMCA).
50: Endocrine Autoantibodies.
51: Gastric Autoantibodies.
52: Thyroid Autoantibodies: Thyroid Peroxidase and Thyroglobulin Antibodies.
53: Thyrotropin Receptor Antibodies.
54: Glutamic Acid Decarboxylase Antibody.
55: Antibodies to Gonadal and Adrenal Tissue.
56: Humoral Immunity in Type 1 Diabetes Mellitus.
57: Gi and Liver Autoantibodies.
58: Autoantibody Profile in Inflammatory Bowel Disease.
59: Anti-Intestinal Goblet Cell Antibodies.
60: Antipancreatic Autoantibodies.
61: Cryoglobulins and Cryoglobulins Secondary to Hepatitis C Virus Infection.
62: Autoantibodies in Autoimmune Hepatitis.
63: Antitissue Transglutaminase and Antiendomysial Antibodies.
64: Antigliadin and Antideamidated Gliadin Peptide Antibodies.
65: Liver Cytosol Antigen Type 1 Autoantibodies (LC-1), Liver Kidney Microsomal Autoantibodies (LKM), and Liver Microsomal Autoantibodies (LM).
66: Antimitochondrial Antibodies.
67: Smooth Muscle Autoantibodies.
68: Hematologic Autoantibodies.
69: Coagulation Factor Autoantibodies.
70: Autoantibodies in Heparin-Induced Thrombocytopenia.
71: Platelet Autoantibodies.
72: Red Cell Autoantibodies.
73: Lymphocytotoxic Autoantibodies.
74: Kidney Autoantibodies.
75: Anti-Phospholipase A2 Receptor Autoantibodies.
76: Glomerular Basement Membrane Autoantibodies.
77: Nephritic Factor Autoantibodies.
78: IgA Nephropathies.
79: Neurological System Autoantibodies.
80: Acetylcholine Receptor and Muscle-Specific Kinase Autoantibodies.
81: Human Anti-Glycosphingolipids Antibodies in Guillain-Barré Syndrome.
82: Central Nervous System Neuronal Surface Antibodies.
83: Antibodies to AQP4.
84: Myositis Autoantibodies.
85: Myelin Oligodendrocyte Glycoprotein (MOG): An Archetypal Target for Demyelinating Autoantibodies in the Central Nervous System.
86: Autoantibodies in the Lambert-Eaton Myasthenic Syndrome (LEMS) and Amyotrophic Lateral Sclerosis (ALS).
87: Antimyelin-Associated GlycoProtein, Antimyelin Basic Protein, and Antiproteolipid Autoantibodies in Neurologic Diseases.
88: Paraneoplastic Neurologic Antibodies.
89: Retinal Autoantibodies.
90: Rheumatic Disease Autoantibodies.
91: Antifodrin Antibodies.
92: Antibodies to Laminin.
93: Autoantibodies against Muscarinic Acetylcholine Receptor in Patients with Sjögren Syndrome.
94: β2-Glycoprotein I Autoantibodies.
95: C1 Inhibitor Autoantibodies.
96: Autoantibodies to C1q.
97: Anticollagen Antibodies.
98: Antiendothelial Cell Antibodies.
99: Lupus Anticoagulant Testing.
100: Anticardiolipin Antibodies.
101: Phospholipid AutoAntibodies (Nonanticardiolipin)-Antiprothrombin Antibodies.
102: Rheumatoid Factors.
103: Antibodies to Specific Citrullinated Proteins in Rheumatoid Arthritis.
104: Skin Disease Autoantibodies.
105: Autoantibodies to Mucocutaneous Antigens.
106: Unique Clinical Situations.
107: Autoimmunity and the Newer Biopharmaceuticals.
108: Antibodies against “Human” Biopharmaceuticals: Individualized Therapy with TNF-Alpha Inhibitors Guided by Immunopharmacologic Assessments.
109: Autoantibodies and Pregnancy Loss.
110: Autoantibodies – Future Trends.