Placebo and Pain, 1st Edition

  • Published By:
  • ISBN-10: 0123979315
  • ISBN-13: 9780123979315
  • DDC: 616.0472
  • Grade Level Range: College Freshman - College Senior
  • 312 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013

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The placebo effect continues to fascinate scientists, scholars, and clinicians, resulting in an impressive amount of research, mainly in the field of pain. While recent experimental and clinical studies have unraveled salient aspects of the neurobiological substrates and clinical relevance of pain and placebo analgesia, an authoritative source remained lacking until now. By presenting and integrating a broad range of research, Placebo and Pain enhances readers' knowledge about placebo and nocebo effects, reexamines the methodology of clinical trials, and improves the therapeutic approaches for patients suffering from pain.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Table of Contents.
1: Historical Aspects of Placebo Analgesia.
2: Neurochemistry of Placebo Analgesia: Opioids, Cannabinoids and Cholecystokinin.
3: Placebo Analgesia in Rodents.
4: Molecular Mechanisms of Placebo Responses in Humans.
5: How does EEG Contribute to Our Understanding of the Placebo Response? Insights from the Perspective of Bayesian Inference.
6: Spinal Mechanisms of Placebo Analgesia and Nocebo Hyperalgesia: Descending Inhibitory and Facilitatory Influences.
7: Spinal and Supraspinal Mechanisms of Placebo Analgesia.
8: Positive and Negative Emotions and Placebo Analgesia.
9: Placing Placebo in Normal Brain Function with Neuroimaging.
10: Brain Predictors of Individual Differences in Placebo Responding.
11: Placebo Responses, Antagonistic Responses, and Homeostasis.
12: Placebo Analgesia, Nocebo Hyperalgesia, and Acupuncture.
13: The Relevance of Placebo and Nocebo Mechanisms for Analgesic Treatments.
14: How Placebo Responses are Formed: From Bench to Bedside.
15: Methodologic Aspects of Placebo Research.
16: Balanced Placebo Design, Active Placebos, and Other Design Features for Identifying, Minimizing and Characterizing the Placebo Response.
17: Psychological Processes that can Bias Responses to Placebo Treatment for Pain.
18: Against ‘Placebo.’ The Case for Changing our Language, and for the Meaning Response.
19: Placebo Effects in Complementary and Alternative Medicine: The Self-Healing Response.
20: Conceptualizations and Magnitudes of Placebo Analgesia Effects Across Meta-Analyses and Experimental Studies.
21: The Contribution of Desire, Expectation, and Reduced Negative Emotions to Placebo Anti-Hyperalgesia in Irritable Bowel Syndrome.
22: The Wound that Heals: Placebo, Pain and Surgery.
23: What are the Best Placebo Interventions for the Treatment of Pain?.
24: How Communication between Clinicians and Patients may Impact Pain Perception.
25: Nocebos in Daily Clinical Practice: The Potential Side Effects of the Treatment Context and the Patient–Doctor Interaction on Pain in Clinical Populations.
26: The Potential of the Analgesic Placebo Effect in Clinical Practice – Recommendations for Pain Management.
27: Placebo and Nocebo: Ethical Challenges and Solutions.
Color Plates.