Glycoscience: Chemistry and Chemical Biology, 2nd Edition

  • Published By:
  • ISBN-10: 3540304290
  • ISBN-13: 9783540304296
  • Grade Level Range: College Freshman - College Senior
  • 2874 Pages | eBook
  • Original Copyright 2007 | Published/Released August 2008
  • This publication's content originally published in print form: 2007

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About

Overview

  • Completely revised and updated to reflect the "quantum jump" in the field of glycostructures
  • Practical and accessible eReference format
  • Three new chapters on: Key Technology and Tools, Biosynthesis and Glycomedicine
  • Includes more than 12,000 chemical reactions and more than 9,000 references
  • Available in print and electronic

    Here is yet another of Springer’s Major Reference Works in its accessible and practical eReference version.

    It’s an utterly essential resource for scientists in a huge range of disciplines, covering the key area of Glycoscience, a rapidly evolving field with applications across the spectrum. As a reflection of the quantum leap that has been made in the study of glycostructures, the first edition of this book has been completely revised and updated.

    The editors provide up-to-date information on glycostructures, their chemistry and chemical biology in the form of a completely comprehensive survey.

    The texts are illustrated by more than 2500 figures, chemical structures and reaction schemes (including more than 12,000 individual chemical reactions), and more than 9,000 references.

    Glycostructures play highly diverse and crucial roles in a myriad of organisms and important systems in biology, physiology, medicine, bioengineering and technology.

    Only in recent years have the tools been developed to partly understand the highly complex functions and the chemistry behind them.

    While many facts remain undiscovered, this MRW has been contributed to by a large number of the world’s leading researchers in the field, and thus constitutes the very latest information on this exciting topic.

  • Table of Contents

    Front Cover.
    Half Title Page.
    Title Page.
    Copyright Page.
    Preface.
    Table of Contents.
    Editorial Page.
    Editorial Page.
    List of Contributors.
    1: General Principles.
    2: Structure and Conformation of Carbohydrates.
    3: General Properties, Occurrence, and Preparation of Carbohydrates.
    4: General Synthetic Methods.
    5: Reactions at Oxygen Atoms.
    6: Oxidation, Reduction, and Deoxygenation.
    7: Heteroatom Exchange.
    8: Anhydrosugars.
    9: C–C Bond Formation.
    10: C=C Bond Formation.
    11: Degradations and Rearrangement Reactions.
    12: Chemical Glycosylation Reactions.
    13: Glycosyl Halides.
    14: Glycosyl Trichloroacetimidates.
    15: Further Anomeric Esters.
    16: O–Glycosyl Donors.
    17: S–Glycosylation.
    18: Glycal Derivatives.
    19: Anomeric Anhydro Sugars.
    20: C–Glycosylation.
    21: Monosaccharides.
    22: Monosaccharides: Occurrence, Significance, and Properties.
    23: Monosaccharides and Polyols in Foods.
    24: De novo Synthesis of Monosaccharides.
    25: Monosaccharides as Chiral Pools for the Synthesis of Complex Natural Compounds.
    26: Monosaccharides as Scaffolds for the Synthesis of Novel Compounds.
    27: Monosaccharides as Chiral Auxiliaries and Ligands for Asymmetric Synthesis.
    28: Carbohydrate-Metal Complexes: Structural Chemistry of Stable Solution Species.
    29: Oligosaccharides.
    30: Oligosaccharides: Occurrence, Significance, and Properties.
    31: Sucrose and Related Oligosaccharides.
    32: Oligosaccharides in Food and Agriculture.
    33: Combinatorial Methods in Oligosaccharide Synthesis.
    34: Polymer-Supported and Tag-Assisted Methods in Oligosaccharide Synthesis.
    35: Stereoselective Synthesis of βmanno-Glycosides.
    36: Selective α-Sialylation.
    37: Enzymatic Glycosylation by Transferases.
    38: Enzymatic Glycosylation by Glycohydrolases and Glycosynthases.
    39: Complex Polysaccharides.
    40: Polysaccharides: Occurrence, Significance, and Properties.
    41: Starch: Structure, Properties, Chemistry, and Enzymology.
    42: Cellulose and Associated Heteropolysaccharides.
    43: Gums and Related Polysaccharides.
    44: Bacterial Cell Wall Components.
    45: Glycolipids.
    46: Glycolipids: Occurrence, Significance, and Properties.
    47: Synthesis of Glycolipids.
    48: Gangliosides in the Nervous System: Biosynthesis and Degradation.
    49: Chemical Synthesis of Glycosylphosphatidylinositol (GPI) Anchors and GPI-Linked Structures.
    50: Glycoproteins.
    51: Glycoproteins: Occurrence and Significance.
    52: Glycoproteins: Properties.
    53: Biologically Relevant Glycopeptides: Synthesis and Applications.
    54: Glycosylation Engineering of Glycoproteins.
    55: Glycoprotein Analysis.
    56: Glycomimetics.
    57: Azaglycomimetics: Natural Occurrence, Biological Activity, and Application.
    58: Carbasugars: Synthesis and Functions.
    59: Sulpher-Containing Glycomimetics.
    60: C–Glycosyl Analogs of Oligosaccharides.
    61: Oligosaccharide Mimetics.
    62: Key Technologies and Tools for Functional Glycobiology.
    63: Key Technologies and Tools for Functional Glycobiology: Introduction.
    64: Microarrays – A Key Technology for Glycobiology.
    65: Non–Natural Sugar Analogues: Chemical Probes for Metabolic Oligosaccharide Engineering.
    66: Glycomics and Mass Spectrometry.
    67: Informatics Tools for Glycomics: Assisted Interpretation and Annotation of Mass Spectra.
    68: Biosynthesis and Degradation.
    69: Biosynthesis and Degradation of Mono-, Oligo-, and Polysaccharides: Introduction.
    70: Molecular Basis for the Biosynthesis of Oligo- and Polysaccharides.
    71: Polysaccharide Degradation.
    72: Glycomedicine.
    73: Novel Approaches for Glycodrug Discovery.
    74: Biomedicine of Monosaccharides.
    75: Structure and Function of Mammalian Carbohydrate-Lectin Interactions.
    76: Multivalency in Protein–Carbohydrate Recognition.
    77: Biomedicine of Enkephalin-Derived Glycopeptide Analgesics.
    78: Antitumor and Antimicrobial Glycoconjugates.
    79: Glycoside vs. Aglycon: The Role of Glycosidic Residue in Biological Activity.
    80: Mucin–Based Vaccines.
    81: Polysaccharide-Based Vaccines.
    Appendix.
    Nomenclature of Carbohydrates.
    Index.
    Front Cover.
    Half Title Page.
    Title Page.
    Copyright Page.
    Preface.
    Table of Contents.
    Editorial Page.
    Editorial Page.
    List of Contributors.
    1: General Principles.
    2: Structure and Conformation of Carbohydrates.
    3: General Properties, Occurrence, and Preparation of Carbohydrates.
    4: General Synthetic Methods.
    5: Reactions at Oxygen Atoms.
    6: Oxidation, Reduction, and Deoxygenation.
    7: Heteroatom Exchange.
    8: Anhydrosugars.
    9: C–C Bond Formation.
    10: C=C Bond Formation.
    11: Degradations and Rearrangement Reactions.
    12: Chemical Glycosylation Reactions.
    13: Glycosyl Halides.
    14: Glycosyl Trichloroacetimidates.
    15: Further Anomeric Esters.
    16: O–Glycosyl Donors.
    17: S–Glycosylation.
    18: Glycal Derivatives.
    19: Anomeric Anhydro Sugars.
    20: C–Glycosylation.
    21: Monosaccharides.
    22: Monosaccharides: Occurrence, Significance, and Properties.
    23: Monosaccharides and Polyols in Foods.
    24: De novo Synthesis of Monosaccharides.
    25: Monosaccharides as Chiral Pools for the Synthesis of Complex Natural Compounds.
    26: Monosaccharides as Scaffolds for the Synthesis of Novel Compounds.
    27: Monosaccharides as Chiral Auxiliaries and Ligands for Asymmetric Synthesis.
    28: Carbohydrate-Metal Complexes: Structural Chemistry of Stable Solution Species.
    29: Oligosaccharides.
    30: Oligosaccharides: Occurrence, Significance, and Properties.
    31: Sucrose and Related Oligosaccharides.
    32: Oligosaccharides in Food and Agriculture.
    33: Combinatorial Methods in Oligosaccharide Synthesis.
    34: Polymer-Supported and Tag-Assisted Methods in Oligosaccharide Synthesis.
    35: Stereoselective Synthesis of βmanno-Glycosides.
    36: Selective α-Sialylation.
    37: Enzymatic Glycosylation by Transferases.
    38: Enzymatic Glycosylation by Glycohydrolases and Glycosynthases.
    39: Complex Polysaccharides.
    40: Polysaccharides: Occurrence, Significance, and Properties.
    41: Starch: Structure, Properties, Chemistry, and Enzymology.
    42: Cellulose and Associated Heteropolysaccharides.
    43: Gums and Related Polysaccharides.
    44: Bacterial Cell Wall Components.
    45: Glycolipids.
    46: Glycolipids: Occurrence, Significance, and Properties.
    47: Synthesis of Glycolipids.
    48: Gangliosides in the Nervous System: Biosynthesis and Degradation.
    49: Chemical Synthesis of Glycosylphosphatidylinositol (GPI) Anchors and GPI-Linked Structures.
    50: Glycoproteins.
    51: Glycoproteins: Occurrence and Significance.
    52: Glycoproteins: Properties.
    53: Biologically Relevant Glycopeptides: Synthesis and Applications.
    54: Glycosylation Engineering of Glycoproteins.
    55: Glycoprotein Analysis.
    56: Glycomimetics.
    57: Azaglycomimetics: Natural Occurrence, Biological Activity, and Application.
    58: Carbasugars: Synthesis and Functions.
    59: Sulpher-Containing Glycomimetics.
    60: C–Glycosyl Analogs of Oligosaccharides.
    61: Oligosaccharide Mimetics.
    62: Key Technologies and Tools for Functional Glycobiology.
    63: Key Technologies and Tools for Functional Glycobiology: Introduction.
    64: Microarrays – A Key Technology for Glycobiology.
    65: Non–Natural Sugar Analogues: Chemical Probes for Metabolic Oligosaccharide Engineering.
    66: Glycomics and Mass Spectrometry.
    67: Informatics Tools for Glycomics: Assisted Interpretation and Annotation of Mass Spectra.
    68: Biosynthesis and Degradation.
    69: Biosynthesis and Degradation of Mono-, Oligo-, and Polysaccharides: Introduction.
    70: Molecular Basis for the Biosynthesis of Oligo- and Polysaccharides.
    71: Polysaccharide Degradation.
    72: Glycomedicine.
    73: Novel Approaches for Glycodrug Discovery.
    74: Biomedicine of Monosaccharides.
    75: Structure and Function of Mammalian Carbohydrate-Lectin Interactions.
    76: Multivalency in Protein–Carbohydrate Recognition.
    77: Biomedicine of Enkephalin-Derived Glycopeptide Analgesics.
    78: Antitumor and Antimicrobial Glycoconjugates.
    79: Glycoside vs. Aglycon: The Role of Glycosidic Residue in Biological Activity.
    80: Mucin–Based Vaccines.
    81: Polysaccharide-Based Vaccines.
    Appendix.
    Nomenclature of Carbohydrates.
    Index.