Animal Models for the Study of Human Disease, 1st Edition

  • Published By:
  • ISBN-10: 0124159125
  • ISBN-13: 9780124159129
  • DDC: 616.027
  • Grade Level Range: College Freshman - College Senior
  • 1108 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013

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Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. TheĀ first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
List of Contributors.
1: Ethics, Resources and Approaches.
2: Ethics in Biomedical Animal Research.
3: Access to Resources.
4: The Advent of the Golden Era of Animal Alternatives.
5: Environmental Enrichment for Animals Used in Research.
6: Vision.
7: Animal Models of Age-Related Macular Degeneration.
8: N-Methyl-N-Nitrosourea Animal Models for Retinitis Pigmentosa.
9: Cardiac and Cardiovascular.
10: Animal Models of Myocardial Disease.
11: Animal Models for Cardiovascular Research.
12: Cardiovascular Models: Heart Secondarily Affected by Disease.
13: Models for the Study of Atherosclerosis and Thrombosis.
14: Obesity, Metabolic and LIVer.
15: Animal Models of Metabolic Syndrome.
16: Invertebrates in Obesity Research: A Worm’s Perspective.
17: Animal Models of Dietary-Induced Obesity.
18: Animal Models for Manipulation of Thermogenesis.
19: Animal Models of Cholestasis.
20: Bone and Skin.
21: Animal Models of Bone Diseases-A.
22: Animal Models of Bone Disease-B.
23: Animal Models for Implant-Associated Osteomyelitis.
24: Animal Models of Fibrosis in Human Disease.
25: Urinary Tract, Kidney and Bowel.
26: Animal Models of Lower Urinary Tract Dysfunction.
27: Animal Models of Calcium Oxalate Kidney Stone Formation.
28: Animal Models of Inflammatory Bowel Disease for Drug Discovery.
29: The Brain, Stroke, and Neuromuscular.
30: Animal Models of Stroke versus Clinical Stroke Comparison of Infarct Size, Cause, Location, Study Design, and Efficacy of Experimental Therapies.
31: Animal Models and Methods to Study the Relationships between Brain and Tissues in Metabolic Regulation.
32: Models of Alzheimer’s Disease.
33: Neurotoxin 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Animal Models for Parkinson’s Disease.
34: The Importance of Olfactory and Motor Endpoints for Zebrafish Models of Neurodegenerative Disease.
35: Behavior.
36: Animal Models of Drug Abuse: Place and Taste Conditioning.
37: Animal Models of Reward Behavior.
38: Modeling Schizophrenia in Animals.
39: Genetics.
40: Mouse Models for the Exploration of Klinefelter’s Syndrome.
41: Genetically Tailored Pig Models for Translational Biomedical Research.
42: Genetically Modified Animal Models.
43: Mouse Models for Human Diseases by Forward and Reverse Genetics.
44: Early Life.
45: Animal Models for the Study of Infection-Associated Preterm Birth.
46: Animal Models of Febrile Seizures.
47: Viral Disease.
48: Human Herpesviruses and Animal Models.
49: Animal Models of Human Viral Diseases.
50: Cancer.
51: Xenograft, Transgenic, and Knockout Models of Prostate Cancer.
52: Animal Models for Studying Prevention and Treatment of Breast Cancer.
53: Sclerosis.
54: Animal Models of Systemic Sclerosis.
55: Animal Models for the Study of Multiple Sclerosis.