Oligomerization in Health and Disease, 1st Edition

  • Published By:
  • ISBN-10: 0123869501
  • ISBN-13: 9780123869500
  • DDC: 572.633
  • Grade Level Range: College Freshman - College Senior
  • 656 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013

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This special volume of Progress in Molecular Biology and Translational Science focuses on oligomerization in health and disease.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
1: Structural, Physicochemical, and Evolutionary Aspects of Protein Oligomerization.
2: Evolutionary, Physicochemical, and Functional Mechanisms of Protein Homooligomerization.
3: Structural, Evolutionary, and Assembly Principles of Protein Oligomerization.
4: Physicochemical Principles of Protein Aggregation.
5: Structural Aspects of Amyloid Formation.
6: Oligomerization in Seven-Transmembrane Receptors.
7: Quaternary Structure Predictions and Structural Communication Features of GPCR Dimers.
8: Challenges in the Development of Heteromer-GPCR-Based Drugs.
9: Di/Oligomerization of GPCRs—Mechanisms and Functional Significance.
10: G Protein-Coupled Receptor Heterocomplexes in Neuropsychiatric Disorders.
11: Disease-Specific Heteromerization of G-Protein-Coupled Receptors That Target Drugs of Abuse.
12: Oligomerization in Ion Channels.
13: Social Networking Among Voltage-Activated Potassium Channels.
14: Oligomerization of the Mitochondrial Protein VDAC1: From Structure to Function and Cancer Therapy.
15: Consequences of Dimerization of the Voltage-Gated Proton Channel.
16: Receptor Heteromeric Assembly—How It Works and Why It Matters: The Case of Ionotropic Glutamate Receptors.
17: Oligomerization in Enzymes.
18: The Structural Basis for the Allosteric Regulation of Ribonucleotide Reductase.
19: Oligomerization of Dynamin Superfamily Proteins in Health and Disease.
20: Multimerization of the Dnmt3a DNA Methyltransferase and Its Functional Implications.
21: Oligomerization in Endoplasmic Reticulum Stress Signaling.
22: Oligomerization in Regulatory Proteins.
23: Toll-IL-1-Receptor-Containing Adaptor Molecule-1: A Signaling Adaptor Linking Innate Immunity to Adaptive Immunity.
24: Assembly of Gamma-Tubulin Ring Complexes: Implications for Cell Biology and Disease.
25: Chemokine Oligomerization in Cell Signaling and Migration.
26: Oligomerization of Rab/Effector Complexes in the Regulation of Vesicle Trafficking.
Other Backmatter.