Epigenetic Regulation in the Nervous System, 1st Edition

  • Published By:
  • ISBN-10: 0123944058
  • ISBN-13: 9780123944054
  • DDC: 616.80442
  • Grade Level Range: College Freshman - College Senior
  • 374 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013

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Epigenetic Regulation in the Nervous System addresses current understanding of the role of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential role of these mechanisms in neurological and psychiatric disorders. This award-winning book discusses molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models. It is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies. This book is a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses of experimentation. Covering background material and topics of current interest, it serves as a cutting-edge resource and foundational reference. The book will benefit researchers and graduate students with an interest in the links between gene regulation and behavior and clinicians dealing with addiction, depression, and schizophrenia.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
List of Contributors.
1: An Overview of the Molecular Basis of Epigenetics.
2: Histone Modifications in the Nervous System and Neuropsychiatric Disorders.
3: Active DNA Demethylation and 5-Hydroxymethylcytosine.
4: The Epigenetics of Parental Effects.
5: Epigenetic Mechanisms in Learning and Memory.
6: Drug Addiction and Reward.
7: The Mind and its Nucleosomes – Chromatin (dys)Regulation in Major Psychiatric Disease.
8: HDAC Inhibitors as Novel Therapeutics in Aging and Alzheimer's Disease.
9: miRNAs and Neurodevelopmental Disorders.
10: Imprinting in the CNS and Neurodevelopmental Disorders.
11: Neuronal Genomic and Epigenetic Diversity.
12: Adult Neurogenesis.
13: Transgenerational Inheritance in Mammals.
14: Epigenetics: Defining the Frontiers of Genomic Function.