Comprehensive Medicinal Chemistry II, 1st Edition

  • Published By:
  • ISBN-10: 008045044X
  • ISBN-13: 9780080450445
  • Grade Level Range: College Freshman - College Senior
  • 6819 Pages | eBook
  • Original Copyright 2007 | Published/Released April 2008
  • This publication's content originally published in print form: 2007

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The first edition of Comprehensive Medicinal Chemistry, published in 1990, was very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more.

The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Contents of all Volumes.
Preface to Volume 1.
Editor of Volume 1.
Contributors to Volume 1.
Historical Perspective and Outlook.
1: 1.01 Reflections of a Medicinal Chemist: Formative Years through Thirty-Seven Years Service in the Pharmaceutical Industry.
2: 1.02 Drug Discovery: Historical Perspective, Current Status, and Outlook.
3: 1.03 Major Drug Introductions.
The Impact of New Genomic Technologies.
4: 1.04 Epigenetics.
5: 1.05 Personalized Medicine.
6: 1.06 Gene Therapy.
Sources of New Drugs.
7: 1.07 Overview of Sources of New Drugs.
8: 1.08 Natural Product Sources of Drugs: Plants, Microbes, Marine Organisms, and Animals.
9: 1.09 Traditional Medicines.
10: 1.10 Biological Macromolecules.
11: 1.11 Nutraceuticals.
Animal Experimentation.
12: 1.12 Alternatives to Animal Testing.
The Role of Industry.
13: 1.13 The Role of Small- or Medium-Sized Enterprises in Drug Discovery.
14: 1.14 The Role of the Pharmaceutical Industry.
15: 1.15 The Role of the Venture Capitalist.
16: 1.16 Industry-Academic Relationships.
Drug Discovery: Revolution, Decline?.
17: 1.17 Is the Biotechnology Revolution a Myth?.
18: 1.18 The Apparent Declining Efficiency of Drug Discovery.
Healthcare in the Social Context.
19: 1.19 How Much Is Enough or Too Little: Assessing Healthcare Demand in Developed Countries.
20: 1.20 Health Demands in Developing Countries.
21: 1.21 Orphan Drugs and Generics.
Ethical Issues.
22: 1.22 Bioethical Issues in Medicinal Chemistry and Drug Treatment.
23: 1.23 Ethical Issues and Challenges Facing the Pharmaceutical Industry.
Funding and Regulation of Research.
24: 1.24 The Role of Government in Health Research.
25: 1.25 Postmarketing Surveillance.
Intellectual Property.
26: 1.26 Intellectual Property Rights and Patents.