Half Title Page.
1: Introduction and Scientific Principles.
2: From Hemoglobin Based Oxygen Carrier to Oxygen Therapeutics, Blood Substitutes, Nanomedicine and Artificial Cells.
3: From the Atmosphere to the Mitochondrion: The Oxygen Cascade.
4: Biochemistry of Hemoglobin.
5: The Role of Blood and Plasma Viscosity in Restoring Oxygen Delivery Capacity.
6: Hemorrhagic Shock and Current Treatments.
7: Pathophysiology of Hemorrhagic Shock and Resuscitation.
8: Allogeneic Blood Transfusion for Surgical and Traumatic Hemorrhage.
9: Pre-Hospital Fluid Resuscitation in Civilian and Military Populations.
10: Current Issues of HBOCs and Regulatory Framework.
11: NIH/FDA/DOD Interagency Working Group on Oxygen Therapeutics.
12: Regulatory Framework for Hemoglobin-Based Oxygen Carrier Trials.
13: Approaches to HBOCs.
14: HBOCs from Chemical Modification of Hb.
15: Design of Nonhypertensive Conjugated Hemoglobins as Novel Resuscitation Fluids.
16: Cellular-Type Hemoglobin-Based Oxygen Carriers to Mimic the Red Blood Cell Structure.
17: Recombinant Octameric Hemoglobins as Resuscitation Fluids in a Murine Model of Traumatic Brain Injury Plus Hemorrhagic Shock.
18: Liposome-Encapsulated Hemoglobin as an Artificial Oxygen Carrier: Technological Features, Manufacturing and Issues for Practical Application.
19: Zero-Link Hemoglobin (Oxyvita®): Impact of Molecular Design Characteristics on Pre-Clinical Studies.
20: Polynitroxylated Pegylated Hemoglobin (PNPH): A Nanomedicine for Critical Care and Transfusion.
21: ATP-Adenosine-GSH Crosslinked Hb, An Oxygen Carrier with Pharmacological Properties for Multiple Therapeutic Indications.
22: Albumin-Heme Oxygen Carriers.
23: Recombinant Human Hb-SOD Fusion Proteins.
24: In-Vitro Production of Functional RBCs from Hematopoietic Stem Cells.
25: Potential Applications of HBOCs.
26: Liposome-Encapsulated Hemoglobin: Potential Clinical Applications.
27: Biocompatibility of Hemoglobin Vesicles, a Cellular-Type Artificial Oxygen Carrier, on Blood Cells and Plasma Proteins In Vitro and In Vivo.
28: Polymerized Human Placenta Hemoglobin: Organ Protective Effects and Alternative Clinical Uses.
29: Low Volume Resuscitation with HBOCs in Hemorrhagic Shock.
30: Ischemic Rescue with Hemoglobin-Based Oxygen Carriers.
31: Preclinical Evaluations of HBOCs.
32: Pre-Clinical Evaluation of Hemoglobin Based Oxygen Carriers: Animal Models and Biomarkers.
33: The Hemoglobin-Based Oxygen Carrier, HBOC-201, as a Resuscitation Fluid for Traumatic Hemorrhagic Shock: the Naval Medical Research Center Experience.
34: Cellular-Type Hemoglobin-Based Oxygen Carrier as a Resuscitative Fluid for Hemorrhagic Shock: Acute and Long-Term Safety Evaluation Using Beagle Dogs.
35: HBOC Clinical Trials.
36: Key Adverse Events in Recent HBOC Phase III Clinical Trials and Their Causal Relationship to Test HBOC’s.
37: Some Critical Comments on the Major HBOC Clinical Trials.
38: Compassionate Use Cases Treated with Hemoglobin-Based Oxygen Carriers.
39: HBOC-Mediated Adverse Effects.
40: Acellular Hemoglobin-Based Oxygen Carrier Mediated Blood Pressure Elevation and Vasoconstriction: A Review of Proposed Mechanisms and Contributing Factors.
41: HBOCs and Cardiac Integrity.
42: Effects of Hemoglobin-Based Oxygen Carriers on Blood Coagulation.
43: Redox Activity of Cell-Free Hemoglobin: Implications for Vascular Oxidative Stress and Endothelial Dysfunction.
44: HBOC Interferences with Routine Clinical Laboratory Tests.
45: Vasoconstriction, Hypertension and Oxidative Toxicity are Regulated by Polymerized Hemoglobin Size.
46: Acellular Hemoglobin-Based Oxygen Carrier Induced Vasoactivity: A Brief Review of Potential Pharmacologic Remedies.
47: A Call for Collaborative Research and Development.
48: International Consortium for Development of Hemoglobin-Based Oxygen Carriers, Oxygen Therapeutics and Multifunctional Resuscitation Fluids–A White Paper.