Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics, 1st Edition

  • Published By:
  • ISBN-10: 364240717X
  • ISBN-13: 9783642407178
  • DDC: 615.399
  • Grade Level Range: College Freshman - College Senior
  • 746 Pages | eBook
  • Original Copyright 2013 | Published/Released May 2014
  • This publication's content originally published in print form: 2013

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Currently, hemoglobin (Hb)-based oxygen carriers (HBOCs) are leading candidates as red blood cell substitutes. In addition, HBOCs are also potential oxygen therapeutics for treatment of patients with critical ischemic conditions due to atherosclerosis, diabetes and other conditions. This book will provide readers a comprehensive review of topics involved in the HBOC development. It focusses on current products and clinical applications as well as on emerging technologies and future prospects.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Dedication Page.
1: Introduction and Scientific Principles.
2: From Hemoglobin Based Oxygen Carrier to Oxygen Therapeutics, Blood Substitutes, Nanomedicine and Artificial Cells.
3: From the Atmosphere to the Mitochondrion: The Oxygen Cascade.
4: Biochemistry of Hemoglobin.
5: The Role of Blood and Plasma Viscosity in Restoring Oxygen Delivery Capacity.
6: Hemorrhagic Shock and Current Treatments.
7: Pathophysiology of Hemorrhagic Shock and Resuscitation.
8: Allogeneic Blood Transfusion for Surgical and Traumatic Hemorrhage.
9: Pre-Hospital Fluid Resuscitation in Civilian and Military Populations.
10: Current Issues of HBOCs and Regulatory Framework.
11: NIH/FDA/DOD Interagency Working Group on Oxygen Therapeutics.
12: Regulatory Framework for Hemoglobin-Based Oxygen Carrier Trials.
13: Approaches to HBOCs.
14: HBOCs from Chemical Modification of Hb.
15: Design of Nonhypertensive Conjugated Hemoglobins as Novel Resuscitation Fluids.
16: Cellular-Type Hemoglobin-Based Oxygen Carriers to Mimic the Red Blood Cell Structure.
17: Recombinant Octameric Hemoglobins as Resuscitation Fluids in a Murine Model of Traumatic Brain Injury Plus Hemorrhagic Shock.
18: Liposome-Encapsulated Hemoglobin as an Artificial Oxygen Carrier: Technological Features, Manufacturing and Issues for Practical Application.
19: Zero-Link Hemoglobin (Oxyvita®): Impact of Molecular Design Characteristics on Pre-Clinical Studies.
20: Polynitroxylated Pegylated Hemoglobin (PNPH): A Nanomedicine for Critical Care and Transfusion.
21: ATP-Adenosine-GSH Crosslinked Hb, An Oxygen Carrier with Pharmacological Properties for Multiple Therapeutic Indications.
22: Albumin-Heme Oxygen Carriers.
23: Recombinant Human Hb-SOD Fusion Proteins.
24: In-Vitro Production of Functional RBCs from Hematopoietic Stem Cells.
25: Potential Applications of HBOCs.
26: Liposome-Encapsulated Hemoglobin: Potential Clinical Applications.
27: Biocompatibility of Hemoglobin Vesicles, a Cellular-Type Artificial Oxygen Carrier, on Blood Cells and Plasma Proteins In Vitro and In Vivo.
28: Polymerized Human Placenta Hemoglobin: Organ Protective Effects and Alternative Clinical Uses.
29: Low Volume Resuscitation with HBOCs in Hemorrhagic Shock.
30: Ischemic Rescue with Hemoglobin-Based Oxygen Carriers.
31: Preclinical Evaluations of HBOCs.
32: Pre-Clinical Evaluation of Hemoglobin Based Oxygen Carriers: Animal Models and Biomarkers.
33: The Hemoglobin-Based Oxygen Carrier, HBOC-201, as a Resuscitation Fluid for Traumatic Hemorrhagic Shock: the Naval Medical Research Center Experience.
34: Cellular-Type Hemoglobin-Based Oxygen Carrier as a Resuscitative Fluid for Hemorrhagic Shock: Acute and Long-Term Safety Evaluation Using Beagle Dogs.
35: HBOC Clinical Trials.
36: Key Adverse Events in Recent HBOC Phase III Clinical Trials and Their Causal Relationship to Test HBOC’s.
37: Some Critical Comments on the Major HBOC Clinical Trials.
38: Compassionate Use Cases Treated with Hemoglobin-Based Oxygen Carriers.
39: HBOC-Mediated Adverse Effects.
40: Acellular Hemoglobin-Based Oxygen Carrier Mediated Blood Pressure Elevation and Vasoconstriction: A Review of Proposed Mechanisms and Contributing Factors.
41: HBOCs and Cardiac Integrity.
42: Effects of Hemoglobin-Based Oxygen Carriers on Blood Coagulation.
43: Redox Activity of Cell-Free Hemoglobin: Implications for Vascular Oxidative Stress and Endothelial Dysfunction.
44: HBOC Interferences with Routine Clinical Laboratory Tests.
45: Vasoconstriction, Hypertension and Oxidative Toxicity are Regulated by Polymerized Hemoglobin Size.
46: Acellular Hemoglobin-Based Oxygen Carrier Induced Vasoactivity: A Brief Review of Potential Pharmacologic Remedies.
47: A Call for Collaborative Research and Development.
48: International Consortium for Development of Hemoglobin-Based Oxygen Carriers, Oxygen Therapeutics and Multifunctional Resuscitation Fluids–A White Paper.