Comprehensive Biomedical Physics, 1st Edition

  • Anders Brahme
  • Published By:
  • ISBN-10: 0444536337
  • ISBN-13: 9780444536334
  • DDC: 610.153
  • Grade Level Range: College Freshman - College Senior
  • 3382 Pages | eBook
  • Original Copyright 2014 | Published/Released April 2015
  • This publication's content originally published in print form: 2014

  • Price:  Sign in for price



Comprehensive Biomedical Physics is a new reference work that provides the first point of entry to the literature for all scientists interested in biomedical physics. It is of particularly use for graduate and postgraduate students in the areas of medical biophysics. This Work is indispensable to all serious readers in this interdisciplinary area where physics is applied in medicine and biology. Written by leading scientists who have evaluated and summarized the most important methods, principles, technologies and data within the field, Comprehensive Biomedical Physics is a vital addition to the reference libraries of those working within the areas of medical imaging, radiation sources, detectors, biology, safety and therapy, physiology, and pharmacology as well as in the treatment of different clinical conditions and bioinformatics.

This Work will be valuable to students working in all aspect of medical biophysics, including medical imaging and biomedical radiation science and therapy, physiology, pharmacology and treatment of clinical conditions and bioinformatics.

Table of Contents

Front Cover.

Half Title Page.

Title Page.

Copyright Page.

Editorial Board.




Introduction to Volume 1: Nuclear Medicine and Molecular Imaging.

1: History of Nuclear Medicine and Molecular Imaging.

2: Single-Photon Radionuclide Imaging and SPECT.

3: Dynamic Single-Photon Emission Computed Tomography.

4: Scatter Correction in SPECT.

5: Compton Emission Tomography.

6: Positron Emission Tomography.

7: Time-of-Flight Positron Emission Tomography*.

8: Time-of-Flight PET Reconstruction Strategies.

9: Positron Emission Tomography (PET)/Computer Tomography (CT).

10: High-Resolution Small Animal Imaging.

11: Emission Tomography Motion Compensation.

12: Tracer Kinetic Models in PET.

13: Absorbed Radiation Dose Assessment from Radionuclides.

Front Cover.

Half Title Page.

Title Page.



Introduction to Volume 2: X-Ray and Ultrasound Imaging.

1: Physical Basis of x-Ray Imaging.

2: Physical Parameters of Image Quality.

3: Computed Tomography.

4: Oral and Maxillofacial Radiology.

5: Breast Imaging.

6: Dual-Energy and Spectral Imaging.

7: Quality Controls in x-Ray Imaging.

8: x-Ray Imaging with Coherent Sources.

9: High-Resolution CT for Small-Animal Imaging Research.

10: Radiation Protection and Dosimetry in x-Ray Imaging.

11: Fundamentals of CT Reconstruction in 2D and 3D.

12: The Basics of Ultrasound.

13: Ultrasound Imaging Arrays.

14: Doppler Ultrasound.

15: Ultrasound Imaging Modalities.

16: Nonlinear Acoustics.

17: Biomedical Applications of Ultrasound.

18: Biological Effects in Diagnostic Ultrasound.

19: Simulation of Ultrasound Fields.

20: Ultrasound Research Platforms.

Front Cover.

Half Title Page.

Title Page.



Introduction to Volume 3: Magnetic Resonance Imaging and Spectroscopy.

1: Fundamentals of MR Imaging.

2: Image Contrast and Resolution in MRI.

3: Perfusion Imaging and Hyperpolarized Agents for MRI.

4: High versus Low Static Magnetic Fields in MRI.

5: Functional Magnetic Resonance Imaging (fMRI).

6: Diffusion-Weighted MRI.

7: MRI of the Brain.

8: MRI of the Cardiovascular System.

9: MRI of the Liver.

10: MRI of the Pancreas and Kidney.

11: MRI of the Small and Large Bowel.

12: MR Imaging of the Prostate.

13: MRI of the Breast.

14: MRI of the Female Genitourinary Tract.

15: Three-Dimensional Multispectral MRI for Patients with Metal Implants.

16: Fundamentals of MR Spectroscopy.

17: Magnetic Resonance Spectroscopy (MRS) of the Brain.

18: MR Spectroscopy (MRS) of the Prostate.

19: MRS of the Breast.

20: Potential and Obstacles of MRS in the Clinical Setting.

21: Magnetic Resonance Spectroscopic Imaging.

22: Clinical Applications of Magnetic Resonance Spectroscopic Imaging.

23: In Vivo Two-Dimensional Magnetic Resonance Spectroscopy.

24: Basic Science Input into Clinical MR Modalities.

25: Mathematically Optimized MR Reconstructions.

26: Interdisciplinarity of MR and Future Perspectives with a Focus on Screening.

Front Cover.

Half Title Page.

Title Page.



Introduction to Volume 4: Optical Molecular Imaging.

1: Bio-Optical Imaging.

2: Signal-Relevant Properties of Fluorescent Labels and Optical Probes and Their Determination.

3: Fluorescent Proteins.

4: Fluorescent Nanoparticles.

5: Molecular Imaging Probes: Activatable and Sensing Probes.

6: Fluorescence Resonance Energy Transfer Probes.

7: Multimodal Optical Imaging Probes.

8: Fluorescent Reporters and Optical Probes.

9: Advanced Fluorescence Microscopy.

10: Uncovering Tumor Biology by Intravital Microscopy*.

11: Two-Photon Microscopy.

12: Optical Frequency-Domain Imaging.

13: Raman-Based Technologies for Biomedical Diagnostics.

14: Optical Coherence Tomography.

15: Two-Dimensional in Vivo Fluorescence Imaging.

16: Bioluminescence Imaging.

17: Inverse Models for Diffuse Optical Molecular Tomography.

18: Hybrid Optical Imaging.

19: Optoacoustic Imaging.

20: Fluorescence-Guided Surgery: A Promising Approach for Future Oncologic Surgery.

21: Confocal Laser Endomicroscopy Applications.

22: Optical Imaging in Mammography.

23: External Transdermal Procedures.

24: High Content Screening and Analysis with Nanotechnologies.

Front Cover.

Half Title Page.

Title Page.



Introduction to Volume 5: Physics of Physiological Measurements.

1: Electrical Activities in the Body.

2: Electrocardiography.

3: Bioelectric Measurements: Magnetoencephalography.

4: Tissue Impedance Spectroscopy and Impedance Imaging.

5: Blood Flow Measurement.

6: Measurement of Temperatures of the Human Body.

7: Force Measurements.

8: Smart Homes: Ambient Intelligence and How IT Can Help Increase Longevity.

9: Wearable Sensors.

Front Cover.

Half Title Page.

Title Page.



Introduction to Volume 6: Bioinformatics.

1: Artificial Neural Networks.

2: Learning Rule-Based Models – The Rough Set Approach.

3: Algorithms for Mapping High-Throughput DNA Sequences*.

4: Text Mining.

5: Semantic Web, Ontologies, and Linked Data.

6: Nomenclature of Genes and Proteins.

7: Phylogenetic Analyses.

8: Computational Approaches for Predicting Mutation Effects on RNA Structure.

9: Chemoinformatics.

10: Lipidomics in Metabolomics.

11: Genome-Scale Metabolic Models: A Link between Bioinformatics and Systems Biology.

12: EBI and ELIXIR.

13: Databases and Datasources at SIB, Swiss Institute of Bioinformatics.

Front Cover.

Half Title Page.

Title Page.



Introduction to Volume 7: Radiation Biology and Radiation Safety.

1: Early Events Leading to Radiation-Induced Biological Effects.

2: Microbeam Radiation Biology.

3: Molecular Radiation Biology.

4: Cellular Radiation Biology.

5: Normal Tissue Radiobiology.

6: Tumor Radiation Biology.

7: Accurate Analytical Description of the Cell Survival and Dose–Response Relationships at Low and High Doses and LETs.

8: Genetic Susceptibility and Predictive Assays.

9: Genetic Effects and Risk Estimation.

10: Light Ion Radiation Biology.

11: Radiological Protection of Patients and Personnel.

12: Radiation Biology of Radiation Protection.

13: Radiation Biology of Tissue Radiosterilization.

14: Established and Emerging Methods of Biological Dosimetry.

15: Radiation and Environmental Protection.

16: Biological Effects and Health Consequences of ELF and RF Fields.

Front Cover.

Half Title Page.

Title Page.



Introduction to Volume 8: Radiation Sources and Detectors.

1: Electron Linear Accelerators.

2: Synchrotron Radiation.

3: Inverse Compton Scattering Sources.

4: Tabletop Synchrotron Light Source.

5: Free-Electron Laser Sources.

6: Petawatt Laser and Laser Ion/Electron Accelerator.

7: Electron-Impact Liquid-Metal-Jet Hard x-Ray Sources.

8: Laser-Impact Metal Droplet EUV Source.

9: x-Ray Free-Electron Lasers.

10: Ion Linac and Synchrotron.

11: FFAG.

12: Cyclotrons.

13: Neutron Sources.

14: Radionuclide Production.

15: Diamond Detectors for Dosimetry.

16: Scintillator-Based Detectors.

17: Active Pixel CMOS-Based Radiation Detectors.

18: CdTe Detectors.

19: Amorphous Silicon Detectors.

20: Selenium Detectors.

21: Silicon Photomultipliers.

22: Gas Electron Multiplier (GEM) Detectors: Principles of Operation and Applications.

23: Silicon Trackers.

Front Cover.

Half Title Page.

Title Page.



Introduction to Volume 9: Radiation Therapy Physics and Treatment Optimization.

1: Interaction of Ionizing Radiation with Matter.

2: Particle Transport Theory and Absorbed Dose.

3: Biophysical Basis of Ionizing Radiation.

4: Modeling of Radiation Effects in Cells and Tissues.

5: From Cell Survival to Dose–Response Relations for Organized Tissues.

6: Dose–Response Relations for Tumors and Normal Tissues.

7: Accurate Description of Heterogeneous Tumors by Their Effective Radiation-Sensitive and -Resistant Cell Compartments.

8: Tumor Hypoxia.

9: Long-Term Effects and Secondary Tumors.

10: Patient Dose Computation.

11: Convolutions and Deconvolutions in Radiation Dosimetry.

12: Fundamentals of Physically and Biologically Based Radiation Therapy Optimization.

13: Brachytherapy Physics.

14: Stereotactic Radiation Therapy Planning.

15: Modulated Arc Therapy Planning.

16: In-Room Image-Guided Radiation Therapy.

17: Intensity-Modulated Radiation Therapy Planning.

18: Adaptive Treatment Planning.

19: Light-Ion Radiation Therapy Planning.

20: Stereotactic Radiation Therapy.

21: Biologically Optimized Light Ion Therapy.

Front Cover.

Half Title Page.

Title Page.



1: Biomechanics of Musculoskeletal Adaptation.

2: Mechanics of Biofluids in Living Body.

3: Bioelectromagnetism in the Living Body.

4: Ion Channels in the Cell Membrane: Structure, Function, and Modeling.

5: Water Biology in Human Body.

6: Human Immune System.

7: Hyperthermia Therapy for Cancer.

8: Ultrasound Therapy.

9: Laser Surgery.

10: Photodynamic Techniques in Medicine.

11: Electro-Muscle Stimulation Therapy.

12: Defibrillation.

13: Electroporation Therapy.

14: Transcranial Magnetic Stimulation.

15: Biophysical Bases of Acupuncture.

16: Music Psychophysics and Therapy.

17: Medical Bionics.

18: Cold Plasma Therapy.

19: Smart-Drug Delivery and Target-Specific Therapy.

20: Orthopedic Physical Therapy.

21: Neurological Rehabilitation.

22: Pulmonary Rehabilitation.

23: Principles and Applications of Vestibular Rehabilitation.


Front Cover.

Half Title Page.

Title Page.