Cancer Nanotechnology: Principles and Applications in Radiation Oncology, 1st Edition

  • Sang Hyun Cho
  • Published By: CRC Press
  • ISBN-10: 1439878765
  • ISBN-13: 9781439878767
  • DDC: 616.99
  • Grade Level Range: College Freshman - College Senior
  • 284 Pages | eBook
  • Original Copyright 2013 | Published/Released March 2016
  • This publication's content originally published in print form: 2013

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Rapid advances in nanotechnology have enabled the fabrication of nanoparticles from various materials with different shapes, sizes, and properties, and efforts are ongoing to exploit these materials for practical clinical applications. Nanotechnology is particularly relevant in the field of oncology, as the leaky and chaotic vasculature of tumors—a hallmark of unrestrained growth—results in the passive accumulation of nanoparticles within tumors.

Cancer Nanotechnology: Principles and Applications in Radiation Oncology is a compilation of research in the arena of nanoparticles and radiation oncology, which lies at the intersection of disciplines as diverse as clinical radiation oncology, radiation physics and biology, nanotechnology, materials science, and biomedical engineering. The book provides a comprehensive, cross-disciplinary survey of basic principles, research techniques, and outcomes with the goals of eventual clinical translation.

Reflecting profound advances in the application of nanotechnology to radiation oncology, this comprehensive volume demonstrates how the unique physicochemical properties of nanoparticles lead to novel strategies for cancer treatment and detection. Along with various computational and experimental techniques, each chapter highlights the most promising approaches to the use of nanoparticles for radiation response modulation.

Table of Contents

Front Cover.
Half Title Page.
Other Frontmatter.
Title Page.
Copyright Page.
Series Preface.
About the Editors.
Basic Principles of Radiation Oncology and Radiosensitization.
1: Basic Principles of Radiation Therapy of Cancers.
2: Biological Principles of Radiosensitization.
3: Principles and Application of Hyperthermia Combined with Radiation.
Synthesis, Safety, and Imaging of Nanomaterials for Cancer Applications.
4: Synthesis and Surface Modification of Nanomaterials for Tumor Targeting.
5: Safety Concerns for Nanomaterials in Nanomedicinal Applications.
6: Imaging with Nanoparticles.
7: Optical Microscopy of Plasmonic Nanoparticles.
8: X-Ray Fluorescence Computed Tomography Imaging of Nanoparticles.
Nanomaterials for Radiation Therapy.
9: Gold Nanoparticle-Mediated Radiosensitization.
10: Quantification of Gold Nanoparticle-Mediated Radiation Dose Enhancement.
11: Semiconductor Nanomaterials for Radiotherapy.
12: Radioactive Gold Nanoparticles for Tumor Therapy.
13: Nanoparticles for Selective Radioprotection of Normal Tissues.
Nanomaterials for Hyperthermia and Thermal Therapy.
14: Gold Nanoparticle-Mediated Hyperthermia in Cancer Therapy.
15: Magnetic Resonance Temperature Imaging for Gold Nanoparticle-Mediated Thermal Therapy.
16: Modeling of Plasmonic Heat Generation from Gold Nanoparticles.
17: Carbon Nanotubes for Thermal Therapy.
Future Outlook.
18: Regulatory Issues for Clinical Translations.
19: Clinical Translations of Nanotechnology: Present and Future Outlook.
Color Plates.