Cancer Genomics, 1st Edition

  • Published By:
  • ISBN-10: 0123972744
  • ISBN-13: 9780123972743
  • DDC: 616.994042
  • Grade Level Range: College Freshman - College Senior
  • 510 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013

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Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics.

Table of Contents

Front Cover.
Half Title Page.
Other Frontmatter.
Title Page.
Copyright Page.
List of Contributors.
1: Introduction.
2: Historical Perspective and Current Challenges of Cancer Genomics.
3: Genomics Technologies, Concepts and Resources.
4: Second-Generation Sequencing for Cancer Genome Analysis.
5: Cancer Transcriptome Sequencing and Analysis.
6: The Significance of Transcriptome Sequencing in Personalized Cancer Medicine.
7: Tissue Microarrays in Studying Gynecological Cancers.
8: Cancer Pharmacogenomics in Children.
9: Biomarker Discovery and Development through Genomics.
10: Preclinical Animal Models for Cancer Genomics.
11: Bioinformatics for Cancer Genomics.
12: Genomic Resource Projects.
13: Hereditary Cancer Syndromes.
14: Genetic Basis of Hereditary Cancer Syndromes.
15: Genomics of Adult and Pediatric Cancers.
16: Adult Solid Tumors.
17: Genomics and Molecular Profiling of Lung Cancer.
18: Breast Cancer Genomics.
19: Prostate Cancer Genomics as a Driver of Personalized Medicine.
20: Genomics of Colorectal Cancer.
21: Thyroid Cancer.
22: Age Non-Specific Tumors and Hematopoietic Malignancies.
23: Acute Myeloid Leukemia.
24: Genomics in Multiple Myeloma: From Conventional Cytogenetics to Novel Whole-Genome Sequencing Approaches.
25: Brain Tumor Genomics: Sequencing to Clinical Utility.
26: Pediatric Cancers.
27: Genomic Basis of Pediatric Lymphomas.
28: Neuroblastoma.
29: Soft Tissue Sarcomas.
30: Wilms Tumors.
31: Ethics of Genomics Research.
32: Cancer Genomics and Biobanking: Exploring Key Ethical and Legal Issues.
33: Future Directions.
34: The Role of MicroRNAs and Ultraconserved Non-Coding RNAs in Cancer.
35: The Impact of the Environment on Cancer Genomics.