Biological DNA Sensor, 1st Edition

  • Published By:
  • ISBN-10: 0124051685
  • ISBN-13: 9780124051683
  • DDC: 610.28
  • Grade Level Range: College Freshman - College Senior
  • 368 Pages | eBook
  • Original Copyright 2013 | Published/Released May 2014
  • This publication's content originally published in print form: 2013

  • Price:  Sign in for price



Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
1: List of Contributors.
2: The Discovery of dsDNA Immunogenicity and the Definition of DNA Sensing Pathways.
3: Route to Discovering the Immunogenic Properties of DNA from TLR9 to Cytosolic DNA Sensors.
4: The PYHIN Family of Molecules and Their Functions Sensing dsDNA.
5: Cytosolic DNA-Sensing and the Sting Pathway.
6: Regulation of Intracellular dsDNA-Induced Innate Immune Responses by Autophagy-Related Proteins.
7: dsDNA and Its Part in Modulating Human Diseases.
8: Host DNA Induced Inflammation and Autoimmune Diseases.
9: Toll-Like Receptor 9 and Toll-Like Receptor 7 in the Development and Regulation of Systemic Autoimmune Disease.
10: Bacterial Infections and the DNA Sensing Pathway.
11: Viral Infections and the DNA Sensing Pathway: Lessons from Herpesviruses and Beyond.
12: Cancer Pathogenesis and DNA Sensing*.
13: DNA Damage Responses in Atherosclerosis.
14: The DNA Sensing Pathway and Its Impact on Vaccinology.
15: DNA Vaccine: Does It Target the Double Stranded-DNA Sensing Pathway?*.
16: Adjuvants Targeting the DNA Sensing Pathways – Alum Based Adjuvants.
17: Adjuvats Targeting the DNA Sensing Pathways – Cyclic-di-GMP and Other Cyclic-Dinucleotides.