Toxoplasma Gondii, 2nd Edition

  • Published By:
  • ISBN-10: 0123965365
  • ISBN-13: 9780123965363
  • DDC: 615.372
  • Grade Level Range: College Freshman - College Senior
  • 1160 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013

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This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists. Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Preface to the First Edition.
Preface to the Second Edition.
List of Contributors.
1: The History and Life Cycle of Toxoplasma gondii.
2: The Ultrastructure of Toxoplasma gondii.
3: Molecular Epidemiology and Population Structure of Toxoplasma gondii.
4: Human Toxoplasma Infection.
5: Ocular Disease due to Toxoplasma gondii.
6: Toxoplasmosis in Wild and Domestic Animals.
7: Toxoplasma Animal Models and Therapeutics.
8: Biochemistry and Metabolism of Toxoplasma gondii.
9: The Apicoplast and Mitochondrion of Toxoplasma gondii.
10: Calcium Storage and Homeostasis in Toxoplasma gondii.
11: The Toxoplasma gondii Parasitophorous Vacuole Membrane.
12: Toxoplasma Secretory Proteins and Their Roles in Cell Invasion and Intracellular Survival.
13: The Toxoplasma Cytoskeleton.
14: Interactions Between Toxoplasma Effectors and Host Immune Responses.
15: Bradyzoite Development.
16: Development and Application of Classical Genetics in Toxoplasma gondii.
17: Genetic Manipulation of Toxoplasma gondii.
18: Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii.
19: ToxoDB: An Integrated Functional Genomic Resource for Toxoplasma and Other Sarcocystidae.
20: Comparative Aspects of Nucleotide and Amino Acid Metabolism in Toxoplasma gondii and Other Apicomplexa.
21: Toxoplasma gondii Chemical Biology.
22: Proteomics of Toxoplasma gondii.
23: Cerebral Toxoplasmosis: Pathogenesis, Host Resistance and Behavioural Consequences.
24: Innate Immunity to Toxoplasma gondii.
25: Adaptive Immunity and Genetics of the Host Immune Response.
26: Vaccination against Toxoplasmosis.