G Protein Coupled Receptors, 1st Edition

  • Volume 522
  • Published By:
  • ISBN-10: 012407944X
  • ISBN-13: 9780124079441
  • DDC: 572.696
  • Grade Level Range: College Freshman - College Senior
  • 528 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013

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This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers G protein coupled receptors, and includes chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation.

Table of Contents

Front Cover.
Half Title Page.
Other Front Page.
Title Page.
Copyright Page.
Methods in Enzymology.
The Protein Local Optimization Program and G-Protein-Coupled Receptors: Loop Restoration and Applications to Homology Modeling.
Modeling Active GPCR Conformations.
Molecular Modeling of Adenosine Receptors.
Predicting G-Protein-Coupled Receptors Families Using Different Physiochemical Properties and Pseudo Amino Acid Composition.
Computational Design and Experimental Characterization of GPCR Segment Models.
G-Protein-Coupled Receptor Interaction with Small GTPases.
Quantification of Receptor Tyrosine Kinase Activation and Transactivation by G-Protein-Coupled Receptors Using Spatial Intensity Distribution Analysis (SpIDA).
NMR Methods for Detection of Small Molecule Binding to RGS4.
Group II Activators of G-Protein Signaling: Monitoring the Interaction of Ga with the G-Protein Regulatory Motif in the Intact Cell.
Homogeneous Time-Resolved Fluorescence Assay to Probe Folded G Protein-Coupled Receptors.
cAMP Biosensors Applied in Molecular Pharmacological Studies of G Protein-Coupled Receptors.
Rhodopsin–Lipid Interactions Studied by NMR.
Biasing the Parathyroid Hormone Receptor: Relating in Vitro Ligand Efficacy to in Vivo Biological Activity.
Application of Monte Carlo-Based Receptor Ensemble Docking to Virtual Screening for GPCR Ligands.
From Heptahelical Bundle to Hits from the Haystack: Structure-Based Virtual Screening for GPCR Ligands.
Kinetics and Dynamics in the G Protein-Coupled Receptor Signaling Cascade.
Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy of G Protein-Coupled Receptors.
Posttranslation Modification of G Protein-Coupled Receptor in Relationship to Biased Agonism.
Protein S-Nitrosylation Measurement.
Author Index.
Subject Index.
Other Backmatter.