Handbook of Research on Systems Biology Applications in Medicine, 1st Edition

  • Published By:
  • ISBN-10: 1605660779
  • ISBN-13: 9781605660776
  • Grade Level Range: College Freshman - College Senior
  • 976 Pages | eBook
  • Original Copyright 2008 | Published/Released March 2009
  • This publication's content originally published in print form: 2008

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Highlights the use of systems approaches including genomic, cellular, proteomic, metabolomic, bioinformatics, molecular, and biochemical, to address fundamental questions in complex diseases like cancer diabetes but also in aging.

Table of Contents

Front Cover.
Title Page.
Copyright Page.
Editorial Advisory Board.
List of Contributors.
Table of Contents.
Detailed Table of Contents.
1: Section I Basic Concepts in Medical Systems Biology.
2: Pathway Biology Approach to Medicine.
3: Systems and Control Theory for Medical Systems Biology.
4: Mathematical Description of Time Delays in Pathways Cross Talk.
5: Deterministic Modeling in Medicine.
6: Synthetic Biology as a Proof of Systems Biology.
7: Section II Advanced Computational Methods for Stytems Bioloby.
8: Computational Models for the Analysis of Modern Biological Data.
9: Computer Aided Knowledge Discovery in Biomedicine.
10: Section III Genomics and Bioinformatics for Systems Biology.
11: Function and Homology of Proteins Similar in Sequence: Phylogenetic Profiling.
12: Computational Methods for the Prediction of GPCRs Coupling Selectivity.
13: Bacterial β-Barrel Outer Membrane Proteins: A Common Structural Theme Implicated in a Wide Variety of Functional Roles.
14: Section IV Experimental Techniques for Systems Biology.
15: Clustering Methods for Gene-Expression Data.
16: Uncovering Fine Structure in Gene Expression Profile by Maximum Entropy Modeling of cDNA Microarray Images and Kernel Density Methods.
17: Gene Expression Profiling with the BeadArray− Platform.
18: The Affymetrix GeneChip® Microarray Platform.
19: Alternative Isoform Detection Using Exon Arrays.
20: Gene Expression in Microbial Systems for Growth and Metabolism.
21: Alternative Splicing and Disease.
22: Section V Systems Biology and Aging.
23: Mathematical Modeling of the Aging Process.
24: The Sebaceous Gland: The Sebaceous Gland: A Model of Hormonal Aging.
25: Section VI Systems Biology Applications in Medicine.
26: Systems Biology Applied to Cancer Research.
27: Systems Biology Strategies in Studies of Energy Homeostasis In Vivo.
28: Approaching Type 2 Diabetes Mellitus by Systems Biology.
29: Systems Biology and Infectious Diseases.
30: Systems Biology of Human-Pathogenic Fungi.
31: Development of Specific Gamma Secretase Inhibitors.
32: In Machina Systems for the Rational De Novo Peptide Design.
33: Applications of Metabolic Flux Balancing in Medicine.
34: Section VIII Data Integration and Data Mining.
35: Multi-Level Data Integration and Data Mining in Systems Biology.
36: Methods for Reverse Engineering of Gene Regulatory Networks.
37: Data Integration for Regulatory Gene Module Discovery.
38: Discrete Networks as a Suitable Approach for the Analysis of Genetic Regulation.
39: Investigating the Collective Behavior of Neural Networks: A Review of Signal Processing Approaches.
40: The System for Population Kinetics: Open Source Software for Population Analysis.
41: Section IX Systems Biology in Photochemical Processes.
42: Photosynthesis: How Proteins Control Excitation Energy Transfer.
43: Photodynamic Therapy: A Systems Biology Approach.
44: Modeling of Porphyrin Metabolism with PyBioS.
45: Section X Modeling Cellular Physiology.
46: Interference Microscopy for Cellular Studies.
47: Fluorescence Imaging of Mitochondrial Long-Term Depolarization in Cancer Cells Exposed to Heat-Stress.
48: Section XI Tools for Molecular Networks.
49: Protein Interactions and Diseases.
50: The Breadth and Depth of BioMedical Molecular Networks: The Reactome Perspective.
51: Section XII Mathematical Modeling Approaches.
52: Entropy and Thermodynamics in Biomolecular Simulation.
53: Model Development and Decomposition in Physiology.
54: A Pandemic Avian Influenza Mathematical Model.
55: Dengue Fever: A Mathematical Model with Immunization Program.
56: Section XIII Data Processing in Histopathology.
57: Automated Image Analysis Approaches in Histopathology.
About the Contributors.