Drug-Induced Liver Disease, 3rd Edition

  • Published By:
  • ISBN-10: 0123878187
  • ISBN-13: 9780123878182
  • DDC: 616.362
  • Grade Level Range: College Freshman - College Senior
  • 776 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013

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This field has shown tremendous growth in recent years, primarily due to the recognition that drug-induced liver disease is the most common cause of liver failure and one of the major contributors to the withdrawal of drugs developed by the pharmaceutical industry. Drug-Induced Liver Disease, 3rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the pharmaceutical industry and government settings. This book contains 4 new chapters on key topics in the area and provides a current and extensive review of the latest developments concerning the toxicology, pharmacology, genetics and immunology of drug-induced liver disease. A multi-authored reference work written by leading clinical, academic and industry experts in drug-induced liver disease. Contains four new chapters on key areas in the field, including one on worldwide drug-induced liver injury networks. Each chapter has been updated to address the latest research and findings in the field and 16 new chapter authors have been added to this new edition. Includes coverage of the basic, clinical and practical aspects of drug-induced liver disease to provide the single most comprehensive reference on the subject.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Table of Contents.
Preface to the Third Edition.
List of Figures.
List of Tables.
List of Contributors.
1: Mechanisms of Liver Injury.
2: Drug-Induced Liver Injury.
3: Cytochrome P450 Activation of Toxins and Hepatotoxicity.
4: Mechanistic Role of Acyl Glucuronides.
5: Oxidant Stress, Antioxidant Defense, and Liver Injury.
6: Hepatotoxicity Due to Mitochondrial Injury.
7: Mechanisms of Cell Death and Relevance to Drug Toxicity.
8: Role of Membrane Transport in Hepatotoxicity and Pathogenesis of Drug-Induced Cholestasis.
9: Liver Sinusoidal Endothelial Cells and Liver Injury.
10: Macrophages and Kupffer Cells in Drug-Induced Liver Injury.
11: Role of Inflammation in Drug-Induced Liver Injury.
12: Role of the Adaptive Immune System in Idiosyncratic Drug-Induced Liver Injury.
13: Role of Tissue Repair and Death Proteins in Liver Injury.
14: Genetic Factors in the Pathogenesis of Drug-Induced Liver Injury.
15: Diagnosis and Management.
16: Clinical Manifestations and Management of Drug-Induced Liver Diseases.
17: Histopathological Evaluation of Drug-Induced Liver Disease.
18: Risk Factors for Drug-Induced Liver Disease.
19: Biomarkers for Drug-Induced Liver Injury.
20: Causality Assessment.
21: Hepatotoxicity of Specific Drugs.
22: Mechanisms of Acetaminophen-Induced Liver Disease.
23: Acetaminophen.
24: Mechanisms Underlying the Hepatotoxicity of Nonsteroidal Antiinflammatory Drugs.
25: Nonsteroidal Antiinflammatory Drugs and Leukotriene Receptor Antagonists.
26: Mechanism, Pathology, and Clinical Presentation of Hepatotoxicity of Anesthetic Agents.
27: Anticonvulsant Agents.
28: Hepatotoxicity of Psychotropic Drugs and Drugs of Abuse.
29: Hepatotoxicity of Antimicrobials and Antifungal Agents.
30: Hepatotoxicity of Antitubercular Drugs.
31: Hepatotoxicity of Antiviral Agents.
32: Hepatotoxicity of Cardiovascular and Antidiabetic Drugs.
33: Cancer Chemotherapy.
34: Hepatotoxicity of Immunosuppressive Drugs.
35: Hepatotoxicity Related to Methotrexate.
36: Adverse Effects of Hormones and Hormone Antagonists on the Liver.
37: Mushroom Poisoning.
38: Hepatotoxicity of Herbals and Dietary Supplements.
39: Occupational and Environmental Hepatotoxicity.
40: Chronic Liver Disease from Drugs.
41: Future Directions.
42: Regulatory Perspectives.
43: Drug-Induced Liver Injury Research Networks.
44: Livertox.