Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, 1st Edition

  • Volume 3
  • Published By:
  • ISBN-10: 0124055346
  • ISBN-13: 9780124055346
  • DDC: 571.655
  • Grade Level Range: College Freshman - College Senior
  • 432 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013

  • Price:  Sign in for price



Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections. Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration.  From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. Brings together oncologists, neurosurgeons, physicians, research scientists, and pathologists in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Other Frontmatter.
Abbreviations and Glossary.
Autophagy: Volume 1–Contributions.
Autophagy: Volume 2–Contributions.
List of Contributions Projected in Volume 4.
1: Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volumes 1–4.
2: Molecular Mechanisms.
3: Autophagic Flux, Fusion Dynamics, and Cell Death.
4: Architecture of the Atg12–Atg5–Atg16 Complex and its Molecular Role in Autophagy.
5: The Molecular Mechanisms Underlying Autophagosome Formation in Yeast.
6: Role of Autophagy in Disease.
7: Role of Autophagy in Cell Survival in Liver Injury.
8: Polymorphisms in Autophagy-Related Genes in Crohn’s Disease Impact on Intracellular Bacteria Persistence and Inflammatory Response.
9: Functional Relevance of Autophagins in Life and Disease.
10: Strategies to Block Autophagy in Tumor Cells.
11: Autophagic Dysfunction in Gaucher Disease and its Rescue by Cathepsin B and D Proteases.
12: Cargo Recognition Failure Underlies Macroautophagy Defects in Huntington’s Disease.
13: Hepatitis C Virus Infection, Autophagy, and Innate Immune Response.
14: Geranylgeranoic Acid Induces Incomplete Autophagy but Leads to the Accumulation of Autophagosomes in Human Hepatoma Cells.
15: Defense Against Proteotoxic Stress in the Heart Role of p62, Autophagy, and Ubiquitin–Proteasome System.
16: Elimination of Intracellular Bacteria by Autophagy.
17: Protein Phosphatase 2A Has Positive and Negative Roles in Autophagy.
18: Role of Autophagy in Cancer.
19: Erufosine Induces Autophagy and Apoptosis in Oral Squamous Cell Carcinoma: Role of the Akt–mTOR Signaling Pathway.
20: Emerging Role of Hypoxia-Induced Autophagy in Cancer Immunotherapy.
21: Involvement of Autophagy and Apoptosis in Studies of Anticancer Drugs.
22: Autophagy-Based Protein Biomarkers for In Vivo Detection of Cardiotoxicity in the Context of Cancer Therapy.
23: Inhibition of mTOR Pathway and Induction of Autophagy Block Lymphoma Cell Growth: Role of AMPK Activation.
24: Autophagy and Apoptosis.
25: Autophagy Regulates Osteoarthritis-Like Gene Expression Changes: Role of Apoptosis and Reactive Oxygen Species.
26: The Key Role of Autophagy and its Relationship with Apoptosis in Lepidopteran Larval Midgut Remodeling.
27: Interferon Regulatory Factor 1 Regulates both Autophagy and Apoptosis in Splenocytes during Sepsis.
28: The Interplay between Autophagy and Apoptosis.