Clinical and Translational Science: Principles of Human Research, 2nd Edition

  • David Robertson Oxford University
  • Gordon H. Williams
  • Published By:
  • ISBN-10: 012802111X
  • ISBN-13: 9780128021118
  • DDC: 616.027
  • Grade Level Range: College Freshman - College Senior
  • 798 Pages | eBook
  • Original Copyright 2017 | Published/Released June 2017
  • This publication's content originally published in print form: 2017

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As the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, this resource provides critical access to new molecular tools and diagnostic technologies to help users gain a better understanding of human disease and the development of new therapeutics for enhanced health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
List of Contributors.
Fundamental Principles.
1: Introduction to Clinical Research.
2: Patient-Oriented Research.
3: Clinical Trials.
4: Introduction to Epidemiology.
5: The Patient-Centered Outcomes Research Institute: Current Approach to Funding Clinical Research and Future Directions.
6: Health-Care Technology Assessment (HTA).
7: Health Services Research: Translating Discovery and Research Into Practice and Policy.
8: Measurement of Biological Materials.
9: Imaging Tools in Clinical Research: Focus on Imaging Technologies.
10: Imaging Tools in Human Research: Focus on Image-Guided Intervention.
11: Nanotechnology in Clinical and Translational Research.
12: The Use of Questionnaires and Surveys.
13: Information Technology.
14: Principles of Biostatistics.
15: Good Clinical Practice and Good Laboratory Practice.
Human Genetics.
16: Introduction to Human Genetics*.
17: Epidemiologic and Population Genetic Studies.
18: Pharmacogenetics of Drug Metabolism.
19: Statistical Techniques for Genetic Analysis.
Human Pharmacology.
20: Introduction to Clinical Pharmacology.
21: Adverse Drug Events.
Societal Context of Human Research.
22: Translating Science to the Bedside: The Innovation Pipeline.
23: Regulatory Environment.
24: Ethical Issues in Translational Research and Clinical Investigation.
25: Clinical Research in the Public Eye.
Research in Special Populations.
26: Research in Special Populations: Acute Illnesses; Critical Care; and Surgical Patients.
27: Research in the Emergency Care Environment.
28: Psychiatric Disorders.
29: Research in Special Populations: Geriatrics.
30: Clinical Research in Neurology.
31: Research in Pediatrics.
32: Cancer as a Paradigm for Translational and Clinical Biomedical Research.
33: Maintaining an Emphasis on Rare Diseases With Research Initiatives and Resources at the National Center for Advancing Translational Sciences.
34: Clinical and Translational Science Infrastructure.
Education, Training and Career Choices.
35: Education, Training and Career Choices: Training Basic, Clinical, and Translational Investigators.
36: A Stepwise Approach to a Career in Translational Research.
37: Physician Careers in the Pharmaceutical Industry.
Research in Academia.
38: Industry-Sponsored Clinical Research in Academia.
39: Governmental Support of Research.
40: The Role of Nonprofit, Nongovernmental Funding in Support of Biomedical Research.
41: Modern Drug Discovery and Development.
42: Pharmaceutical and Biotechnology Sector Support of Research.
43: The Future of Clinical Research.