Encyclopedia of Basic Epilepsy Research, 1st Edition

  • Philip Schwartzkroin
  • Published By:
  • ISBN-10: 0123739616
  • ISBN-13: 9780123739612
  • DDC: 616.853
  • Grade Level Range: College Freshman - College Senior
  • 1761 Pages | eBook
  • Original Copyright 2009 | Published/Released August 2011
  • This publication's content originally published in print form: 2009

  • Price:  Sign in for price



As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of authors, the encyclopedia covers the full spectrum of research activities from genes and molecules to animal models and human patients. The encyclopedia's electronic format also provides unparalleled access to frequent updates and additions, while the limited edition print version provides another option for owning this content. The Encyclopedia of Basic Epilepsy Research is an essential resource for researchers of all levels and clinicians who study epilepsy.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Editor Biography.
Guide to use of the Encyclopedia.
1: Absence Seizures.
2: Genetic Models of Absence Epilepsy: New Concepts and Insights.
3: Increased GABAA Receptor-Mediated Transmission in Typical Absence Seizures.
4: Oscillations in Thalamocortical Networks and the Putative ‘Initiation Site’ of Typical Absence Seizures.
5: Thalamic Neurons and Networks Related to Absence Epilepsy.
6: Thalamocortical Synchronization and Absence Epilepsy.
7: Aging.
8: Effects of Aging on Seizures and Epilepsy.
9: Epilepsy and Seizure Susceptibility in the Aging Brain.
10: Poststroke Epilepsy and the Aged Brain.
11: Antiepileptic Drugs.
12: Anticonvulsant Drugs as Neuronal Network-Modifying Agents.
13: Antiepileptic Drug Mechanisms.
14: GABA Transporters as Targets of Antiepileptic Drugs.
15: Local Delivery of Antiepileptic Drugs.
16: Pathways of Drug Diffusion into the Epileptic Brain.
17: Pharmacological Approaches for the Assessment of Antiepileptic Drug Efficacy in Experimental Animal Models.
18: Preclinical Drug Development in Epilepsy.
19: Cell Damage/Excitotoxicity.
20: Basic Mechanisms of Neuronal Injury from Seizures and Status Epilepticus.
21: Excitotoxicity and Neurodegenerative Disease.
22: Molecular Mechanisms of Cell Death After Seizures.
23: Neuronal Injury and Progressive Cell Damage.
24: Neuronal Injury from Seizures: Influence of Models, Development and Genetics.
25: The Ontogeny of Seizure-Related Programmed Cell Death in the Developing Brain.
26: Cognitive Dysfunction and Other Comorbidities.
27: Attention Deficit Disorder and Epilepsy in Children.
28: Behavioral and Cognitive Comorbidities.
29: Behavioral Comorbidities in Children with Epilepsy.
30: Cognitive Consequences of Seizures Early in Life: Insights from the Kainic Acid Model.
31: Cognitive Effects of Seizures in Animal Models.
32: Cognitive Function in Temporal Lobe Epilepsy.
33: Epilepsy and Autism in Tuberous Sclerosis.
34: Language and Communication Disorders.
35: The Relationship of Epilepsy to Other Conditions/Disorders.
36: Development/Malformations.
37: Cortical Malformations as a Cause for Epileptiform Activity: The Freeze Lesion Model.
38: Epilepsy-Associated Reelin Dysfunction Induces Granule Cell Dispersion in the Dentate Gyrus.
39: Focal Malformations of Cortical Development: Pathogenesis and Pathways.
40: Morphological and Electrophysiological Properties of Abnormal Cells in Pediatric Cortical Dysplasia Tissue.
41: Neonatal Progenitor Contributions to Epilepsy-Associated Cortical Malformations: A Hypothesis.
42: The Tish Rat: An Animal Model of Cortical Malformation in the Study of Epilepsy.
43: Epileptogenesis.
44: Epileptogenesis and Plasticity.
45: Gene Expression in Immature and Mature Hippocampus After Status Epilepticus.
46: Multi-Hit Mechanisms Involved in Epileptogenesis: Role of Early-Life Seizures.
47: Patterns of Gene Expression in Epileptogenesis: Micro-Array Studies in Rats.
48: Role of Transporter Proteins and Lipid Peroxidation in Epileptogenesis.
49: Specific Gene Expression Before and After Seizure in Epileptic EL Mice.
50: Surrogate Markers for Epileptogenesis.
51: Gaba.
52: Alterations in GABAergic Transmission in Human Temporal Lobe Epilepsy.
53: Differential Alterations of GABAA Receptors in Epilepsy.
54: GABA Excites Immature Neurons: Implications for the Epilepsies.
55: GABAA Receptor-Mediated Mechanisms and Epileptiform Synchronization.
56: GABAA Receptor Plasticity in Epileptogenesis.
57: Mechanisms of GABAA Receptor Gene Regulation in Epilepsy.
58: Molecular Pathology of Genetic Epilepsy Associated with GABAA Receptor Subunit Gene Mutations.
59: Pathophysiology of Status Epilepticus.
60: Plasticity of GABAergic Systems during Epileptogenesis.
61: Synchrony through GABAergic Inhibition.
62: Genetics.
63: ARX Gene Mutations and X-linked Infantile Spasms.
64: Cytoskeletal Genes and Idiopathic Epilepsies.
65: Epilepsy Genes that do not Encode Ion Channels.
66: GABRB3 and Childhood Absence Epilepsy.
67: Genetic Association Studies in Human Epilepsy and Pharmacogenetics of Antiepilepsy Drugs.
68: Genetic Contributions to Brain Structure and Epileptogenesis.
69: Genetics of Lafora and Juvenile Myoclonic Epilepsies.
70: Human Epilepsy as a Complex Genetic Trait: Lessons from Animal Models and Prospects for the Future.
71: Role of Genetic Factors in the Etiopathogenesis of Epilepsy-Related Brain Damage.
72: Single Gene Mutations in Inherited and Sporadic Epilepsy.
73: Sixty Years in the Making: A Multifactorial Mouse Model of Seizure Susceptibility.
74: Sleep-Related Epilepsies and Mutations in Acetylcholine Receptors.
75: Glia/Astrocytes.
76: Astrocytic Regulation of Neuronal Excitability.
77: Glial-Mediated Mechanisms of Epileptogenesis in Tuberous Sclerosis.
78: Glial Modulation of Excitability via Glutamate and GABA Transporters.
79: Peritumoral Epilepsy.
80: Properties of Glia in Epileptic Brain.
81: Role of Astrocyte Dysfunction in Epilepsy.
82: Tumor-Induced Epilepsy and Epileptogenic Potential of Brain Tumor Treatment.
83: Glutamate.
84: Functional Reorganization of Inhibitory Circuits in Epilepsy: mGluR1/5 Signaling Mechanisms and Long-Term Plasticity.
85: Glutamate-Mediated Excitation and Mechanisms of Epileptogenesis in the Immature Brain.
86: Metabotropic Kainate Receptor Regulation of Pyramidal Cell Excitability.
87: Persistent Changes in Network Excitability Induced by Group I Metabotropic Glutamate Receptor Activation: Impact on Seizure Expression and Implications for Epileptogenesis.
88: Role of Kainate Receptors in Glutamatergic Synaptic Transmission: Implications for Acute and Chronic Seizure Generation.
89: Granule Cells.
90: Granule-Cell Properties in Seizure Discharge.
91: Phenotypic Plasticity of the Granule Cells and its Relation to Epilepsy.
92: Properties of Dentate Granule Cells and their Relevance to Seizures.
93: Hormones and Gender.
94: Female Sex Steroids and Neuronal Excitability.
95: Hormonal Modulation of Neuronal Excitability.
96: Hormones and Absence Epilepsy.
97: Hormones and Epilepsy.
98: Hormones and Seizures.
99: Male Sex Steroids and Neuronal Excitability.
100: Neurosteroid Modulation of GABAA Receptor-Mediated Synaptic Transmission in an Animal Model of Temporal Lobe Epilepsy.
101: Sex and Seizure Sensitivity.
102: Sex Differences in Seizure Sensitivity.
103: Steroid Hormones and Sex Differences in Seizure Susceptibility.