Anticancer Treatments and Cardiotoxicity: Mechanisms, Diagnostic and Therapeutic Interventions, 1st Edition

  • Patrizio Lancellotti
  • Jose Zamorano
  • Maurizio Galderisi
  • Published By:
  • ISBN-10: 0128026472
  • ISBN-13: 9780128026472
  • DDC: 616.99406
  • Grade Level Range: College Freshman - College Senior
  • 470 Pages | eBook
  • Original Copyright 2017 | Published/Released May 2017
  • This publication's content originally published in print form: 2017

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This book presents cutting edge research on the adverse cardiac effects of both radiotherapy and chemotherapy, brought together by leaders in the field. It describes the most effective diagnostic and imaging tools to evaluate and predict the development of cardiac dysfunction for those patients undergoing cancer treatment. In addition, new guidelines on imaging for the screening and monitoring of these patients are also presented.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
List of Contributors.
How Big is the Problem? The Oncologist’s View.
How Big is the Problem? The Cardiologists’ View.
General Considerations.
1: Epidemiology and Trend of Prognosis in Cancer Patients.
2: Categories of Anticancer Treatments.
3: Classification by Mechanisms of Cardiotoxicity.
4: Cardiotoxicity of Oncologic Treatments.
5: The Impact of Radiotherapy.
Detrimental Effects of Anticancer Drugs and Radiotherapy on the Heart.
6: Lessons From Preclinical Models.
7: Genetic and Epigenetic Risk Factors.
8: Changes of Myocardial Structure and Function.
9: Alteration of Heart Valves.
10: Pericardial Damage.
11: Effects of Radiotherapy on Vessels and Coronary Arteries.
12: Cardiac Conduction Disturbances.
Cardiovascular Complications of Cancer Treatments.
13: Cardiac Rhythm Disturbances.
14: Acute and Chronic Heart Failure.
15: Coronary Artery Disease.
16: Pericardial Effusion and Pericarditis.
17: Radiation-Induced Carotid Atherosclerosis.
18: Valvular Heart Disease.
19: Atrial Fibrillation and Stroke in Cancer Patients.
Imaging Evaluation of Cardiac Structure and Function in Cancer Patients.
20: The Role of Echocardiography.
21: Standard Echo-Doppler Evaluation: LV Systolic and Diastolic Function, Right Ventricular Function, Valvular Heart Disease.
22: Pericardial Disease in Oncologic Patients.
23: The Role of Contrast Echocardiography.
24: Stress Echocardiography.
25: Advanced Echocardiography: Speckle Tracking Echocardiography and 3D Echocardiography.
26: The Role of Cardiovascular Magnetic Resonance (CMR).
27: Nuclear Medicine Imaging and Cardiotoxicity.
Detection of Cardiac Dysfunction and Predictors of Cardiotoxicity.
28: Detection by Cardiac Imaging.
29: The Role of Biomarkers.
30: Screening and Comprehensive Follow-Up Evaluation.
31: Preoperative Assessment for Noncardiac Surgery.
Cardiotoxicity in Childhood.
32: Cardiotoxicity of Childhood Cancer Treatments.
Management of Anticancer Drugs Related Cardiotoxicity.
33: Nonpharmacologic Therapy.
34: Beta-Blockers.
35: Angiotensin-Converting Enzyme Inhibition.
36: Diuretics.
37: Antiarrhythmic Drugs.
38: Anticoagulation in Cancer Patients.
39: New Drugs.
40: Percutaneous Coronary Intervention and Cardiac Surgery in Cancer Patients.
41: Focus on the Patient With Known Cardiac Disease.
42: Multidisciplinary Approach to Cardiac Disease in Cancer Patients.
Future Research Priorities.
43: Pharmacogenomics Screening.
44: Cardiac Monitoring During Clinical Trials.
45: Preventive Therapy.
46: Cardiotoxicity.
Multiple Choice Questions.