Polyphenols in Human Health and Disease, 1st Edition

  • Published By:
  • ISBN-10: 012398467X
  • ISBN-13: 9780123984678
  • DDC: 572.2
  • Grade Level Range: College Freshman - College Senior
  • 1488 Pages | eBook
  • Original Copyright 2014 | Published/Released February 2014
  • This publication's content originally published in print form: 2014

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Polyphenols in Human Health and Disease documents antioxidant actions of polyphenols in protection of cells and cell organelles, critical for understanding their health-promoting actions to help the dietary supplement industry. The book begins by describing the fundamentals of absorption, metabolism and bioavailability of polyphenols, as well as the effect of microbes on polyphenol structure and function and toxicity. It then examines the role of polyphenols in the treatment of chronic disease, including vascular and cardiac health, obesity and diabetes therapy, cancer treatment and prevention, and more.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
About the Editors.
List of Contributors.
1: Overview of Polyphenols and Health.
2: Polyphenols in Foods and Dietary Supplements: Role in Veterinary Medicine and Animal Health.
3: Polyphenols and Public Health.
4: The History of Islamic Medicine at a Glance.
5: Polyphenols and Their Formulations: Different Strategies to Overcome the Drawbacks Associated with Their Poor Stability and Bioavailability.
6: Biological Activities of Polyphenols from Grapes.
7: The Atomic Level Interaction of Polyphenols with the Aβ Oligomer Aggregate, A Molecular Dynamic Guidance for Rational Drug Design.
8: Polyphenols as Supplements in Foods and Beverages: Recent Methods, Benefits and Risks.
9: Polyphenols in Therapy of Obesity and Diabetes.
10: Polyphenols and Diabetes.
11: Anthocyanins and Diabetes Regulation.
12: Influence of Dietary Polyphenols on Carbohydrate Metabolism.
13: Polyphenols in Ayurvedic Medicine and Type 2 Diabetes.
14: Antidiabetic and Anticancer Potential of Native Medicinal Plants from Saudi Arabia.
15: Polyphenols and Obesity.
16: Prevention of Diet-Induced Obesity by Dietary Polyphenols Derived from Nelumbo nucifera and Black Tea.
17: Antidiabetic, Antihyperlipidemic and Antioxidant Effects of the Flavonoids.
18: Dietary Quercetin and Other Polyphenols: Attenuation of Obesity.
19: Role of Protocatechuic Acid in Obesity-Related Pathologies.
20: Food and Supplement Polyphenol Action in Cancer Recurrence.
21: Oxidation and Antioxidant Activity of Polyphenols.
22: Polyphenolic Antioxidants in Health Promotion.
23: Implications of Polyphenols on Endogenous Antioxidant Defense Systems in Human Diseases.
24: Potent Antioxidant and Anti-Inflammatory Flavonoids in the Nutrient-Rich Amazonian Palm Fruit, Açaí (Euterpe spp.).
25: Dark Chocolate/Cocoa Polyphenols and Oxidative Stress.
26: Polyphenol Antioxidants from Natural Sources and Contribution to Health Promotion.
27: Antioxidant Role of Catechin in Health and Disease.
28: Mechanisms of Polyphenols’ Antioxidant Effects.
29: Cytoprotective Effects of Polyphenols against Oxidative Damage.
30: The Role of Direct and Indirect Polyphenolic Antioxidants in Protection against Oxidative Stress.
31: Polyphenols and Low Iron Bioavailability.
32: Galloylation and Polymerization: Role of Structure to Antioxidant Activity of Polyphenols in Lipid Systems.
33: Chemical Properties, Bioavailability, and Metabolomics of Fruit Proanthocyanidins.
34: Polyphenols in Brain and Neurobiology Health.
35: Mechanisms of Polyphenols in Neurobiology.
36: Plant Polyphenols as Dietary Modulators of Brain Functions.
37: Inflammation and Polyphenols.
38: Anti-Inflammatory Activity of Polyphenols on Dendritic Cells.
39: Polyphenols Suppress and Modulate Inflammation: Possible Roles in Health and Disease.
40: Anti-Inflammatory Properties of Cinnamon Polyphenols and Their Monomeric Precursors.
41: Polyphenols in the Prevention of Acute Pancreatitis: Preclinical Observations.
42: Anti-Inflammatory and Immunomodulatory Properties of Dietary Flavonoids.
43: Immunomodulatory Ethnobotanicals of the Great Lakes.
44: Pongamia pinnata (Linn.) Pierre and Inflammation.
45: Polyphenol-Mediated Beneficial Effects in Healthy Status and Disease with Special Reference to Immune-Based Mechanisms.
46: Bioavailability and Effects on Metabolism.
47: Using Recombinant Microorganisms for the Synthesis and Modification of Flavonoids and Stilbenes.
48: Bioavailability of Flavonoids: The Role of Cell Membrane Transporters.
49: Microorganism Metabolic Activity Stimulation by Polyphenols.
50: Interaction of Polyphenols with the Intestinal and Placental Absorption of Some Nutrients and Other Compounds.
51: Bioavailability and Metabolism of Citrus Fruit Beverage Flavanones in Humans.
52: Uptake and Metabolism of Dietary Proanthocyanidins.
53: Bioavailability of Dietary Anthocyanins and Hydroxycinnamic Acids.
54: Microbial Metabolism of Polyphenols and Health.
55: The Impact of Gastrointestinal Modifications, Blood-Brain Barrier Transport, and Intracellular Metabolism on Polyphenol Bioavailability: An Overview.
56: Polyphenolic Regulation of Metabolism.
57: Polyphenols from Pongamia Pinnata (Linn.) Pierre in Metabolic Disorder.
58: Garlic (Allium Sativum): Role in Metabolic Disorder.
59: Polyphenols and Flavonoids in Controlling Non-Alcoholic Steatohepatitis.
60: Modulation of Intestinal Cholesterol Absorption by Dietary Tea Polyphenols.
61: Diverse Disease and Physiological States Modified by Polyphenols.
62: Polyphenols in Clinical Medicine.
63: Polyphenols and Skin Cancers.
64: Polyphenols in the Prevention of Ulcerative Colitis: Past, Present and Future.
65: Protection and Reversal of Hepatic Fibrosis by Polyphenols.
66: Green Tea and Other Fruit Polyphenols Attenuate Deterioration of Bone Microarchitecture.
67: Polyphenolics Evoke Healing Responses: Clinical Evidence and Role of Predictive Biomarkers.
68: Polyphenols and Reproductive Health.
69: Hepatoprotective Effects of Green Tea and Its Polyphenols: Preclinical Observations.
70: Polyphenols and Tuberculosis.
71: Protection by Polyphenols against Mitochondrial Damage and Cytotoxicity.
72: Safety of High and Long-Term Intake of Polyphenols.
73: Polyphenols in Health and Disease: Practice and Mechanisms of Benefits.
74: Curcumin/Turmeric as an Environment-Friendly Stain for Proteins on Acrylamide Gels.
75: Turmeric and Its Principle Compound Curcumin are Effective in the Prevention and Treatment of Arthritis.
76: Polyphenols and Skin.
77: Polyphenols and Polyphenol-Derived Compounds and Contact Dermatitis.
78: Polyphenols against Skin Aging.
79: Skin Photoprotection by Polyphenols in Animal Models and Humans.
80: Polyphenols Nano-Formulations for Topical Delivery and Skin Tissue Engineering.
81: Studying Tea Polyphenols and Their Protective Effects on Skin.
82: Polyphenols: A Remedy for Skin Wrinkles.
Color Plate.
Half Title Page.
Title Page.
Copyright Page.
1: Polyphenols and Vascular Health.
2: Vascular Endothelial Protection of Polyphenols.
3: Vascular Protective Effects of Fruit Polyphenols.
4: Atherosclerosis and Mediterranean Diet Polyphenols.
5: Polyphenol Modulation of Blood Flow and Oxygenation.
6: Flax Lignan in the Prevention of Atherosclerotic Cardiovascular Diseases.
7: Anthocyanins in Vascular Diseases.
8: Cardiac Health and Polyphenols.
9: Polyphenolic Cardiac Modification.
10: Pharmacology of Polyphenols in Cardiac Remodeling: Potential Biological Mechanisms.
11: Cacao Polyphenols Influence the Regulation of Apolipoproteins.
12: Polyphenol Consumption and Blood Pressure.
13: Cardiovascular Effects of Hesperidin: A Flavanone Glycoside.
14: Wine Polyphenols in the Management of Cardiovascular Risk Factors.
15: Polyphenols in Treatment and Prevention of Cardiac Disease.
16: Cocoa, Flavonoids and Cardiovascular Protection.
17: Emerging Applications of Metabolomics to Polyphenols and CVD Biomarker Discovery.
18: Role of Gallic Acid in Cardiovascular Disorders.
19: Cranberry Polyphenols: Effects on Cardiovascular Risk Factors.
20: Polyphenols and the Cardiometabolic Syndrome.
21: Cocoa Polyphenols and Cardiovascular Health.
22: The Use of Bergamot-Derived Polyphenol Fraction in Cardiometabolic Risk Prevention and Its Possible Mechanisms of Action.
23: Fruit Polyphenols and Postprandial Inflammatory Stress.
24: Modulation of Drug-Metabolizing Enzymes and Transporters by Polyphenols as an Anticarcinogenic Effect.
25: Cancer Prevention and Treatment of Polyphenols.
26: Mechanisms of Polyphenol Modulation of Cancer.
27: Polyphenol-Mediated In Vivo Cellular Responses during Carcinogenesis.
28: Preventive Effects of Plant Polyphenols in the Promotion of Mammary Cancer and Testicular Damage Induced by Alcohol Drinking.
29: Antioxidant and Pro-Oxidant Activities of Green Tea Polyphenols in Cancer Prevention.
30: Cancer Chemoprevention by Dietary Polyphenols: Role for Epigenetics and Inflammation.
31: Polyphenols in Prostate Cancer.
32: Modifying Effects of Polyphenols on Acute Colitis and Inflammation-Associated Colon Carcinogenesis.
33: Bioavailability of Soy-Derived Isoflavones and Human Breast Cancer.
34: Biological Activity of Resveratrol on an Ovarian Cancer Cell.
35: Resveratrol Inhibitory Effects against a Malignant Tumor: A Molecular Introductory Review.
36: Inhibition of Iron Absorption by Polyphenols as an Anticancer Mechanism.
37: Cancer Prevention by Polyphenols.
38: Plant Polyphenols as Chemopreventive Agents.
39: Cancer Preventive Effects of Green Tea Polyphenols.
40: Cancer Chemoprevention by Resveratrol Treatment.
41: Polyphenols and Breast Cancer Prevention: A Summary of the Epidemiologic Evidence.
42: Most Relevant Polyphenols Present in the Mediterranean Diet and Their Incidence in Cancer Diseases.
43: BRAF Mutation in Melanoma and Dietary Polyphenols as Adjunctive Treatment Strategy.
44: Radioprotective Effects of the Ocimum Flavonoids Orientin and Vicenin: Observations from Preclinical Studies.
45: Apple Polyphenols in Cancer Prevention.
46: DNA Methylation as a Target of Cancer Chemoprevention by Dietary Polyphenols.
47: Punica Granatum (Pomegranate Fruit): In Cancer Treatment.
Color Plate.