Handbook of Basal Ganglia Structure and Function, 2nd Edition

  • Heinz Steiner
  • Kuei Tseng
  • Published By:
  • ISBN-10: 0128025263
  • ISBN-13: 9780128025260
  • DDC: 612.825
  • Grade Level Range: College Freshman - College Senior
  • 1036 Pages | eBook
  • Original Copyright 2017 | Published/Released January 2017
  • This publication's content originally published in print form: 2017

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This book provides a comprehensive overview of the structural and functional aspects of the basal ganglia. With an emphasis on clinical relevance, it contains ten entirely new chapters that offer expanded coverage of anatomy and physiology, recent advances in cellular/molecular and cellular/physiological mechanisms, and critical, deeper insights into the behavioral and clinical aspects of basal ganglia function and dysfunction.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
List of Contributors.
List of Abbreviations.
The Basal Ganglia System and Its Evolution.
1: The Neuroanatomical Organization of the Basal Ganglia.
2: The History of the Basal Ganglia: The Nuclei.
3: The History of the Basal Ganglia: Cells and Circuits.
4: The Conservative Evolution of the Vertebrate Basal Ganglia.
5: Cell Types in the Different Nuclei of the Basal Ganglia.
Anatomy and Physiology of the Striatum.
6: The Striatal Skeleton: Medium Spiny Projection Neurons and Their Lateral Connections.
7: The Cholinergic Interneuron of the Striatum.
8: GABAergic Interneurons of the Striatum.
9: Dopaminergic Modulation of Glutamatergic Signaling in Striatal Spiny Projection Neurons.
10: Endocannabinoid Signaling in the Striatum.
11: Nitric Oxide Signaling in the Striatum.
12: Role of Adenosine in the Basal Ganglia.
Anatomy and Physiology of Globus Pallidus, Subthalamic Nucleus, and Substantia Nigra.
13: Organization of the Globus Pallidus.
14: The Subthalamic Nucleus.
15: The Substantia Nigra Pars Reticulata.
16: Subtypes of Midbrain Dopamine Neurons.
17: Neurophysiology of Substantia Nigra Dopamine Neurons: Modulation by GABA and Glutamate.
18: Plasticity in Dopamine Neurons.
19: Regulation of Extracellular Dopamine: Release and Uptake.
Network Integration.
20: Organization of Corticostriatal Projection Neuron Types.
21: Organization of Prefrontal-Striatal Connections.
22: Gating of Cortical Input Through the Striatum.
23: Regulation of Corticostriatal Synaptic Plasticity in Physiological and Pathological Conditions.
24: The Thalamostriatal Systems in Normal and Disease States.
25: The Tail of the Ventral Tegmental Area/Rostromedial Tegmental Nucleus: A Modulator of Midbrain Dopamine Systems.
26: The Rostromedial Tegmental Nucleus: Connections with the Basal Ganglia.
27: Integrative Networks Across Basal Ganglia Circuits.
Molecular Signaling in the Basal Ganglia.
28: Receptors and Second Messengers in the Basal Ganglia.
29: Regulation of Striatal Signaling by Protein Phosphatases.
30: Neurotransmitter Regulation of Striatal Gene Expression.
31: Psychostimulant-Induced Gene Regulation in Striatal Circuits.
32: Epigenetics in Neuropathologies of the Basal Ganglia.
Basal Ganglia Function and Dysfunction.
33: Investigating Basal Ganglia Function with Cell-Type-Specific Manipulations.
34: Phasic Dopamine Signaling in Action Selection and Reinforcement Learning.
35: Memory Systems of the Basal Ganglia.
36: Abnormal Activities in Cortico-Basal Ganglia Circuits in Movement Disorders.
37: Morphological Plasticity in the Striatum Associated with Dopamine Dysfunction.
38: Neuroinflammation in Movement Disorders.
39: Disease-Associated Changes in the Striosome and Matrix Compartments of the Dorsal Striatum.
40: Etiology and Progression of Parkinson's Disease: Cross-Talk Between Environmental Factors and Genetic Vulnerability.
41: Determinants of Selective Vulnerability of Dopamine Neurons in Parkinson's Disease.
42: Parkinson's Disease: Genetics.
43: Molecular Mechanisms of L-DOPA-Induced Dyskinesia.
44: Cell Therapy in Parkinson's Disease: Understanding the Challenge.
45: Cellular and Molecular Mechanisms of Neuronal Dysfunction in Huntington's Disease.
46: Alterations of Synaptic Function in Huntington's Disease.
47: Pathophysiology of Dystonia.
48: Tourette Syndrome and Tic Disorders.
49: Deep-Brain Stimulation for Neurologic and Neuropsychiatric Disorders.