Reproductive and Developmental Toxicology, 2nd Edition

  • Ramesh C. Gupta
  • Published By:
  • ISBN-10: 0128042400
  • ISBN-13: 9780128042403
  • DDC: 616.65071
  • Grade Level Range: College Freshman - College Senior
  • 1460 Pages | eBook
  • Original Copyright 2017 | Published/Released February 2018
  • This publication's content originally published in print form: 2017

  • Price:  Sign in for price



This book is a comprehensive and authoritative resource that provides the latest literature on this complex subject with a primary focus on three core components—parent, placenta, and fetus—and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics, including nanoparticles and radiation, gases and solvents, smoking, alcohol and drug abuse, and metals, amongst others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, also including discussions on reproductive and developmental toxicity in domestic animals, fish, and wildlife. Completely revised and updated to include the most recent developments in the field, the book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists, and teratologists from academia, industry, and regulatory agencies.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
List of Contributors.
1: Introduction.
2: Reproductive Anatomy and Physiology.
3: Pharmacokinetics in Pregnancy.
4: Physiologically Based Pharmacokinetic Models in Reproductive and Developmental Toxicology.
5: Drugs and Chemical Contaminants in Human Breast Milk.
Toxicity Testing Models and Safety Evaluation.
6: Reproductive and Developmental Safety Evaluation of New Pharmaceutical Compounds.
7: Juvenile Toxicology Testing.
8: Postmarket Surveillance and Regulatory Considerations in Reproductive and Developmental Toxicology: A Food and Drug Administration Perspective.
9: OECD Guidelines for In Vivo Testing of Reproductive Toxicity.
10: Guidelines for Reproductive and Developmental Toxicity Testing and Risk Assessment of Chemicals.
11: Validated and Nonvalidated Mechanism-Based Methods for Testing Developmental Toxicity.
12: Relevance of Animal Testing and Sensitivity of End Points in Reproductive and Developmental Toxicity.
13: Embryonic Toxic Lesions and Stem Cell Therapy.
14: In Vitro and Alternative Approaches to Developmental Neurotoxicity.
15: In Vitro Biomarkers of Developmental Neurotoxicity.
16: Using Zebrafish to Assess Developmental Neurotoxicity.
17: Caenorhabditis elegans as a Model to Assess Reproductive and Developmental Toxicity.
18: A Primate as an Animal Model for Reproductive and Developmental Toxicology Testing.
Nanoparticles and Radiation.
19: Developmental Toxicity of Engineered Nanomaterials.
20: Toxicity of Radiation: Biological Effects of Ionizing Radiation Exposure on Reproduction.
Gases and Solvents.
21: Reproductive and Developmental Toxicity of Solvents and Gases.
Drugs of Abuse and Addiction, Smoking and Alcohol.
22: Caffeine.
23: Developmental Neurotoxicity of Abused Drugs.
24: Effects of Alcohol on Embryo/Fetal Development.
25: Cigarette Smoking and Reproductive and Developmental Toxicity.
Pharmaceuticals and Food Additives.
26: Thalidomide.
27: Retinoids.
28: Melamine and Cyanuric Acid.
29: Ionophores.
30: Boron.
31: Arsenic, Cadmium, and Lead.
32: Manganese.
33: Mercury.
34: Selenium.
Pesticides, Industrial and Other Environmental Contaminants.
35: Organophosphates and Carbamates.
36: Chlorinated Hydrocarbons and Pyrethrins/Pyrethroids.
37: Herbicides and Fungicides.
38: Brominated Flame Retardants.
39: Polychlorinated Biphenyls, Polybrominated Biphenyls, Polychlorinated Dibenzo-p-dioxins, and Polychlorinated Dibenzofurans.
40: Reproductive Toxicity of Polycyclic Aromatic Hydrocarbons.
41: Toxicity and Risk Assessment of Bisphenol A.
42: Ethylene Glycol.
43: Perfluorooctane Sulfonate and Perfluorooctanoic Acid.
44: Phthalates.
45: Personal Care Products and Cosmetics.
Phytotoxicants, Mycotoxins and Zootoxins.
46: Toxic Plants.
47: Fumonisins.
48: Aflatoxins, Ochratoxins, and Citrinin.
49: Zootoxins.
Special Topics.
50: Systems Toxicology and Predictive Modeling of Male Developmental Toxicity.
51: Stem Cells in Developmental Toxicity Testing.
52: Epigenetics in Reproduction and Development*.
53: Mitochondrial Dysfunction in Reproductive and Developmental Toxicity.
54: Cell Signaling Mechanisms in Developmental Neurotoxicity.
55: Neuroinflammation and Oxidative Injury in Developmental Neurotoxicity.
56: Effects of Stress on Reproductive and Developmental Biology.
57: Disruption of Cholesterol Homeostasis in Developmental Neurotoxicity.
Endocrine Disruption, Mutagenicity, Carcinogenicity, Infertility and Teratogenicity.
58: Endocrine Disruption.
59: Developmental and Reproductive Disorders—Role of Endocrine Disruptors in Testicular Toxicity.
60: Mutagenicity and Carcinogenicity: Human Reproductive Cancer and Risk Factors.
61: Environmental Pollutants and Neural Tube Defects.
62: Teratogenicity.
63: Micro–Computed Tomography and Volumetric Imaging in Developmental Toxicology.
Toxicologic Pathology.
64: Toxicologic Pathology of the Reproductive System.
Placental Toxicity.
65: The Placental Role in Developmental Programming.
66: Strategies for Investigating Hemochorial Placentation.
67: The Significance of ABC Transporters in Human Placenta for the Exposure of Fetus to Xenobiotics.
68: Placental Toxicity.
69: Placental Pathology.
Domestic and Wildlife Species.
70: Reproductive and Developmental Toxicity in Avian Species.
71: Endocrine Disruption in Wildlife Species.
72: Teratogenesis in Livestock.