Inhibitors of the Ras Superfamily G-proteins, Part A, 1st Edition

  • Volume 1
  • Published By:
  • ISBN-10: 0124169678
  • ISBN-13: 9780124169678
  • DDC: 572.696
  • Grade Level Range: College Freshman - College Senior
  • 364 Pages | eBook
  • Original Copyright 2014 | Published/Released June 2014
  • This publication's content originally published in print form: 2014

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This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins.

Table of Contents

Front Cover.
Title Page.
Half Title Page.
Copyright Page.
Table of Contents.
1: The Ras Superfamily G-Proteins.
2: NMR Study to Identify a Ligand-Binding Pocket in Ras.
3: The Allosteric Switch and Conformational States in Ras GTPase Affected by Small Molecules.
4: State 1(T) Inhibitors of Activated Ras.
5: Sugar-Based Inhibitors of Ras Activation: Biological Activity and Identification of Ras–Inhibitor Binding Interface.
6: Development of EHop-016: A Small Molecule Inhibitor of Rac.
7: Aptamer-Derived Peptide Inhibitors of Rho Guanine Nucleotide Exchange Factors.
8: Targeting the Dbl and Dock-Family RhoGEFs: A Yeast-Based Assay to Identify Cell-Active Inhibitors of Rho-Controlled Pathways.
9: Inhibitors of the ROCK Serine/Threonine Kinases: Key Effectors of the RhoA Small GTPase.
10: A Two-Hybrid Approach to Identify Inhibitors of the RAS–RAF Interaction.
11: Inhibitors of K-Ras Plasma Membrane Localization.
12: Ras Chaperones: New Targets for Cancer and Immunotherapy.
Author Index.
Subject Index.