Bioinformatics: Concepts, Methodologies, Tools, and Applications, 1st Edition

  • Published By:
  • ISBN-10: 146663605X
  • ISBN-13: 9781466636057
  • DDC: 572.80285
  • Grade Level Range: College Freshman - College Senior
  • 1246 Pages | eBook
  • Original Copyright 2013 | Published/Released October 2013
  • This publication's content originally published in print form: 2013

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As a result of experimental techniques, the combination of biology and computer science was initiated to classify and process an expanding number of biological observations. Bioinformatics: Concepts, Methodologies, Tools, and Applications highlights the area of bioinformatics and its impact over the medical community with its innovations that change how we recognize and care for illnesses. This publication provides significant research and the most recent observations that are useful for researchers, practitioners, and academicians involved in the many aspects of bioinformatics.

Table of Contents

Front Cover.
Title Page.
Copyright Page.
Other Frontmatter.
List of Contributors.
Table of Contents.
1: Fundamental Concepts and Theories.
2: Overview of Biomedical Engineering.
3: Evaluating a Genetics Concept Inventory.
4: Overview of Knowledge Discovery in Databases Process and Data Mining for Surveillance Technologies and EWS.
5: A Review of Kernel Methods Based Approaches to Classification and Clustering of Sequential Patterns: Sequences of Discrete Symbols.
6: GO-Based Term Semantic Similarity.
7: Parallel Evolutionary Computation in R.
8: Developing a Library Collection in Bioinformatics: Support for an Evolving Profession.
9: Linking Interactome to Disease: A Network-Based Analysis of Metastatic Relapse in Breast Cancer.
10: Knowledge-Driven, Data-Assisted Integrative Pathway Analytics.
11: Medical Informatics and Bioinformatics.
12: An Overview of Graph Indexing and Querying Techniques.
13: Genomics and Population Health: A Social Epidemiology Perspective.
14: Genomics and Genetic Engineering: Playing God?.
15: The Important Role of Lipids in Cognitive Impairment.
16: Virtual Worlds for Teaching: a Comparison of Traditional Methods and Virtual Worlds for Science Instruction.
17: Data Intensive Computing for Bioinformatics.
18: From Bench to Bedside: BACE1, Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1, From Basic Science to Clinical Investigation.
19: Tools and Technologies.
20: Analysis and Prediction of DNA-Recognition by Zinc Finger Proteins: Applications in Genome Modification.
21: Web Services for Bioinformatics.
22: Learning Binding Affinity from Augmented High Throughput Screening Data.
23: Protein Homology Analysis for Function Prediction with Parallel Sub-Graph Isomorphism.
24: Techniques for Named Entity Recognition: A Survey.
25: Neuroimaging in Alzheimer's Disease.
26: Neuronal Transcytosis of WGA Conjugated Protein: A New Approach to Amyloid-β In Vivo.
27: Noninvasive Detection of Misfolded Proteins in the Brain Using [11C]BF-227 PET.
28: Graph Mining Techniques: Focusing on Discriminating between Real and Synthetic Graphs.
29: Current Omics Technologies in Biomarker Discovery.
30: Prediction of Epigenetic Target Sites by Using Genomic DNA Sequence.
31: Biclustering of DNA Microarray Data: Theory, Evaluation, and Applications.
32: Unsupervised Methods to Identify Cellular Signaling Networks from Perturbation Data.
33: Cross-Platform Microarray Data Integration Combining Meta-Analysis and Gene Set Enrichment Analysis.
34: Chemosensitivity Prediction of Tumours Based on Expression, miRNA, and Proteomics Data.
1: Tools and Technologies.
2: FPGA-Based Accelerators for Bioinformatics Applications.
3: Frameworks and Methodologies.
4: Modules in Biological Networks: Identification and Application.
5: A Framework for Networked Experiments in Global E-Science: Perspectives for E-Learning in Global Contexts.
6: Complexity and Modularity of MAPK Signaling Networks.
7: Using Systems Biology Approaches to Predict New Players in the Innate Immune System.
8: Addressing the Challenges of Detecting Epistasis in Genome-Wide Association Studies of Common Human Diseases Using Biological Expert Knowledge.
9: Connecting Microbial Population Genetics with Microbial Pathogenesis: Engineering Microfluidic Cell Arrays for High-Throughput Interrogation of Host-Pathogen Interaction.
10: Hybrid Neural Genetic Architecture: New Directions for Intelligent Recommender System Design.
11: A Two-Layer Learning Architecture for Multi-Class Protein Folds Classification.
12: The Mathematical Modeling and Computational Simulation for Error-Prone PCR.
13: Using a Genetic Algorithm and Markov Clustering on Protein-Protein Interaction Graphs.
14: Kernel Generative Topographic Mapping of Protein Sequences.
15: Incorporating Correlations among Gene Ontology Terms into Predicting Protein Functions.
16: Bifurcation Analysis of a Model Accounting for the 14-3-3σ Signalling Compartmentalisation.
17: Engineering Gene Control Circuits with Allosteric Ribozymes in Human Cells as a Medicine of the Future.
18: Computational Sequence Design Techniques for DNA Microarray Technologies.
19: Cases and Applications.
20: Can Activated Platelet Rich Plasma Combined with Adipose-Derived Stem Cells Be Used to Treat Skin Wrinkles? A Mechanism Study.
21: Analysis of Kinase Inhibitors and Druggability of Kinase-Targets Using Machine Learning Techniques.
22: In Silico Pharmaco-Gene-Informatic Identification of Insulin-Like Proteins in Plants.
23: Molecular Network Analysis of Target RNAs and Interacting Proteins of TDP-43, a Causative Gene for the Neurodegenerative Diseases ALS/FTLD.
24: Chemoinformatics on Metabolic Pathways: Attaching Biochemical Information on Putative Enzymatic Reactions.
25: Improving Prediction Accuracy via Subspace Modeling in a Statistical Geometry Based Computational Protein Mutagenesis.
26: Resolving Sample Traces in Complex Mixtures with Microarray Analyses.
27: Predictive Dynamical Modelling MicroRNAs Role in Complex Networks.
28: Decision Support Systems in the Process of Improving Patient Safety.
29: Graph Applications in Chemoinformatics and Structural Bioinformatics.
30: Visualization of Protein 3D Structures in ‘Double-Centroid’ Reduced Representation: Application to Ligand Binding Site Modeling and Screening.
31: JFeature: A Java Package for Extracting Global Sequence Features from Proteins for Functional Classification.
32: Evaluation of Coupled Nuclear and Cytoplasmic p53 Dynamics.
1: Cases and Applications.
2: Data Mining and Meta-Analysis on DNA Microarray Data.
3: Efficient Computational Construction of Weighted Protein-Protein Interaction Networks Using Adaptive Filtering Techniques Combined with Natural Selection-Based Heuristic Algorithms.
4: BMP Signaling in Regenerative Medicine.
5: Issues and Challenges.
6: Certification and Security Issues in Biomedical Grid Portals: The GRISSOM Case Study.
7: A Comparative Study of an Unsupervised Word Sense Disambiguation Approach.
8: The Impact of Genetic Testing and Genetic Information on Ethical, Legal and Social Issues in North America: The Framework.
9: The Applications of Omics Technologies and the Challenges of Ethics in Nutritional Sciences.
10: A Philosophical Exploration of the Concept of ‘Property’ in Genetics and Databanking: Challenges for Bioethics in Asia and Europe.
11: Genomics Perspectives of Bioethanol Producing Zymomonas Mobilis.
12: Ethics and Privacy Considerations for Systems Biology Applications in Predictive and Personalized Medicine.
13: Ethics, Privacy, and the Future of Genetic Information in Healthcare Information Assurance and Security.
14: Risk-Benefit Analysis of Combination vs. Unopposed HRT in Post-Menopausal Women.
15: Plastika [Totipotenta].
16: Pharmacovigilance: Basic Concepts and Applications of Pharmacoinformatics.
17: Language Focus for Genetics and Molecular Biology Students.
18: Data Analysis and Interpretation in Metabolomics.
19: Promoter Structures Conserved between Homo Sapiens, Mus Musculus and Drosophila Melanogaster.
20: Emerging Trends.
21: A New Approach for Sequence Analysis: Illustrating an Expanded Bioinformatics View through Exploring Properties of the Prestin Protein.
22: Aβ Monomer, Oligomer and Fibril in Alzheimer's Disease.
23: BTISNet: Biotechnology Information Network for Biological Scientific Community.
24: Intelligent Classifiers Fusion for Enhancing Recognition of Genes and Protein Pattern of Hereditary Diseases.
25: Mining Statistically Significant Substrings based on the Chi-Square Measure.
26: Semi-Supervised Clustering for the Identification of Different Cancer Types Using the Gene Expression Profiles.
27: Cancer Gene Expression Data Analysis Using Rough Based Symmetrical Clustering.
28: Computational Methods for Identification of Novel Secondary Metabolite Biosynthetic Pathways by Genome Analysis.
29: Improving PSI-BLAST's Fold Recognition Performance through Combining Consensus Sequences and Support Vector Machine.
30: Towards Optimal Microarray Universal Reference Sample Designs: An In-Silico Optimization Approach.
31: Gene Expression Regulation underlying Osteo-, Adipo-, and Chondro-Genic Lineage Commitment of Human Mesenchymal Stem Cells.
32: Quantum Computing Approach for Alignment-Free Sequence Search and Classification.
33: An Approach for Biological Data Integration and Knowledge Retrieval Based on Ontology, Semantic Web Services Composition, and AI Planning.
34: An Optimization to Protein Coding Regions Identification in Eukaryotes.
35: Use of SciDBMaker as Tool for the Design of Specialized Biological Databases.
36: Emerging Web Tools and Their Applications in Bioinformatics.