The Heart in Rheumatic, Autoimmune and Inflammatory Diseases: Pathophysiology, Clinical Aspects and Therapeutic Approaches, 1st Edition

  • Udi Nussinovitch
  • Published By:
  • ISBN-10: 0128032685
  • ISBN-13: 9780128032688
  • DDC: 616.1
  • Grade Level Range: College Freshman - College Senior
  • 766 Pages | eBook
  • Original Copyright 2017 | Published/Released February 2018
  • This publication's content originally published in print form: 2017

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The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. This book examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
List of Contributors.
About the Editor.
Immune Medicated Cardiac Injury, Accelerated Atherosclerosis and the Study of Cardiac Involvements in Systemic Diseases.
1: Pathophysiology of Autoimmunity and Immune-Mediated Mechanisms in Cardiovascular Diseases.
2: Organ-Specific Autoimmune Myocardial Diseases: From Pathogenesis to Diagnosis and Management.
3: Autoantibodies Directed Against G-Protein- Coupled Receptors in Cardiovascular Diseases: Basics and Diagnostics.
4: Immune-Mediated Accelerated Atherosclerosis.
5: A Study of Cardiac Function, Atherosclerosis, and Arrhythmogenicity.
Cardiac Manifestations of Inflammatory Arthritis.
6: Rheumatoid Arthritis.
7: Juvenile Idiopathic Arthritis.
8: Spondyloarthritides: Ankylosing Spondylitis, Psoriatic Arthritis, and Reactive Arthritis.
9: Polymyalgia Rheumatica.
Cardiac Involvement in Autoimmune and Connective Tissue Diseases.
10: Systemic Lupus Erythematosus.
11: Neonatal Lupus.
12: Sjögren's Syndrome.
13: Systemic Sclerosis.
14: Dermatomyositis and Polymyositis.
Cardiac Manifestations Crystal-Induced Arthritis.
15: Gout.
Cardiac Manifestations of Large Vessel Vasculitides.
16: Giant Cell Arteritis.
17: Takayasu's Arteritis.
Cardiac Manifestations of Medium Vessel Vasculitides.
18: Polyarteritis Nodosa.
19: Kawasaki Disease.
Cardiac Manifestations of Small Vessel Vasculitides.
20: ANCA-Associated Vasculitis: Microscopic Polyangiitis, Eosinophilic Granulomatosis With Polyangiitis (Churg–Strauss Syndrome) and Granulomatosis With Polyangiitis (Wegener's Granulomatosis).
Cardiac Manifestations of Variable Vessel Vasculitides.
21: Behçet's Disease.
Post-Infectious Autoimmune Cardiac Diseases.
22: Rheumatic Fever and Rheumatic Heart Disease.
23: Chagas Cardiomyopathy.
24: Familial Mediterranean Fever.
Therapeutic Approaches: Mechanisms of Action and Cardiac Effects.
25: Desirable and Adverse Effects of Antiinflammatory Agents on the Heart.
26: The Effects of Immunosuppressive and Cytotoxic Drugs on the Heart.
27: Autoantibody-Directed Therapy in Cardiovascular Diseases.
28: Cardiac Immunomodulation.