Biomarkers in Toxicology, 1st Edition

  • Published By:
  • ISBN-10: 0124046495
  • ISBN-13: 9780124046498
  • DDC: 615.9
  • Grade Level Range: College Freshman - College Senior
  • 1152 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013

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Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
List of Contributors.
1: General.
2: Introduction.
3: Rodents Model for Toxicity Testing and Biomarkers.
4: Minipig Models for Toxicity Testing and Biomarkers.
5: Nonhuman Primates in Preclinical Research.
6: Biomarkers of Toxicity in Zebrafish.
7: Caenorhabditis Elegans as a Model for Biomarkers of Diseases and Toxicities.
8: Alternative Animal Toxicity Testing and Biomarkers.
9: Toxicokinetic-toxicodynamic Modeling.
10: Systems Toxicity Biomarkers.
11: Central Nervous System Toxicity Biomarkers.
12: Peripheral Nervous System Toxicity Biomarkers.
13: Cardiovascular Toxicity Biomarkers.
14: Respiratory Toxicity Biomarkers.
15: Hepatic Toxicity Biomarkers.
16: Conventional and Emerging Renal Biomarkers.
17: Gastrointestinal Toxicity Biomarkers.
18: Biomarkers of Acute and Chronic Pancreatitis.
19: Skeletal Muscle Toxicity Biomarkers.
20: Dermal Toxicity Biomarkers.
21: Ocular Biomarkers in Diseases and Toxicities.
22: Biomarkers of Toxicity in Human Placenta.
23: Blood and Bone Marrow Toxicity Biomarkers.
24: Immunotoxicity Biomarkers.
25: Agents Toxicity Biomarkers.
26: Insecticides.
27: Herbicides and Fungicides.
28: Polychlorinated Biphenyls, Polybrominated Biphenyls, and Brominated Flame Retardants.
29: Polycyclic Aromatic Hydrocarbons.
30: Bisphenol A.
31: Melamine.
32: Metals.
33: Chemical and Biological Warfare Agents.
34: Freshwater Cyanotoxins.
35: Mycotoxins.
36: Poisonous Plants.
37: Pharmaceuticals and Nutraceuticals Biomarkers.
38: Biomarkers of Drug Toxicity.
39: Biomarkers of Toxicity for Dietary Ingredients Contained in Dietary Supplements.
40: Nutriphenomics in Rodent Models: Impact of Dietary Choices on Toxicological Biomarkers.
41: Biomarkers of Petroleum Products and Mixtures Toxicity.
42: Biomarkers of Petroleum Products Toxicity.
43: Biomarkers of Chemical Mixture Toxicity.
44: Biomarkers of Radiation, Nanoparticles, and Carcinogenesis.
45: Biomarkers of Radiation Injury and Response.
46: Biomarker Analysis for Nanotoxicology.
47: Engineered Nanomaterials: Biomarkers of Exposure and Effect.
48: Epigenetic Biomarkers in Toxicology.
49: Genotoxicity Biomarkers: Molecular Basis of Genetic Variability and Susceptibility.
50: Risk Factors as Biomarkers of Susceptibility in Breast Cancer.
51: Pancreatic and Ovarian Cancer Biomarkers.
52: Prostate Cancer Biomarkers.
53: Biomonitoring Exposures to Carcinogens.
54: Special Topics.
55: Biomarkers of Alzheimer's Disease.
56: Biomarkers of Parkinson's Disease.
57: Cytoskeletal Disruption as a Biomarker of Developmental Neurotoxicity.
58: Biomarkers of Mitochondrial Dysfunction and Toxicity.
59: Biomarkers of Oxidative/nitrosative Stress and Neurotoxicity.
60: Citrulline: Pharmacological Perspectives and Role as a Biomarker in Diseases and Toxicities.
61: Pathological Biomarkers in Toxicology.
62: Applications of Biomarkers in Toxicology.
63: Biomarkers in Drug Safety Evaluation.
64: Membrane Transporters and Transporter Substrates as Biomarkers for Drug Pharmacokinetics, Pharmacodynamics, and Toxicity/adverse Events.
65: Biomarkers in Biomonitoring of Xenobiotics.
66: Biomarkers of Susceptibility: Pharmacogenomics and Toxicogenomics.
67: Biomarkers for Drugs of Abuse and Neuropsychiatric Disorders: Models and Mechanisms.
68: Microrna Expression as an Indicator of Tissue Toxicity.
69: Percellome Toxicogenomics Project as a Source of Biomarkers of Chemical Toxicity.
70: Transcriptomic Biomarkers in Safety and Risk Assessment of Chemicals.
71: Biomarkers in Computational Toxicology.
72: Biomarkers in Toxicology, Risk Assessment, and Environmental Chemical Regulations.