The Molecular Biology of Arrestins, 1st Edition

  • Published By:
  • ISBN-10: 0123947898
  • ISBN-13: 9780123947895
  • DDC: 574.875
  • Grade Level Range: College Freshman - College Senior
  • 536 Pages | eBook
  • Original Copyright 2014 | Published/Released June 2014
  • This publication's content originally published in print form: 2014

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This special volume of Progress in Molecular Biology and Translational Science focuses on the molecular biology of arrestins, with contributions from leaders in the field. Arrestins have emerged as central players in the regulation of many facets of G protein-coupled receptor signaling. This volume covers a variety of topics with reviews written by experts in the field.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
1: Perspective—The Duality of Arrestin Function.
2: Arrestins Come of Age: A Personal Historical Perspective.
3: The Molecular Biology of Arrestins.
4: True Arrestins and Arrestin-Fold Proteins: A Structure-Based Appraisal.
5: Structural Determinants of Arrestin Functions.
6: Arrestins: Role in the Desensitization, Sequestration, and Vesicular Trafficking of G Protein-Coupled Receptors.
7: Arrestins as Regulators of Kinases and Phosphatases.
8: β-Arrestins: Modulators of Small GTPase Activation and Function.
9: Arrestins and Protein Ubiquitination.
10: Arrestins in Actin Reorganization and Cell Migration.
11: The Physiological Roles of Arrestins.
12: The Role of Arrestins in Development.
13: The Role of Arrestins in Visual and Disease Processes of the Eye.
14: β-Arrestins in the Central Nervous System.
15: Arrestins in the Cardiovascular System.
16: Arrestins in Bone.
17: β-Arrestins in the Immune System.
18: The Role of β-Arrestins in Cancer.
19: Arrestins in Metabolic Regulation.
20: The Future—The Potential for Arrestin-Based Therapeutics.
21: Systems Analysis of Arrestin Pathway Functions.
22: Arrestin Pathways as Drug Targets.