Neuropsychiatric Disorders and Epigenetics, 1st Edition

  • Dag Yasui
  • Jacob Peedicayil
  • Dennis Grayson
  • Published By:
  • ISBN-10: 0128005270
  • ISBN-13: 9780128005279
  • DDC: 616.80442
  • Grade Level Range: College Freshman - College Senior
  • 444 Pages | eBook
  • Original Copyright 2017 | Published/Released May 2017
  • This publication's content originally published in print form: 2017

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This book is a comprehensive reference for the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addiction to obesity contributed by leading experts in their respective fields. The epigenetic aspects for each disorder are discussed, the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states are particularly relevant to disease. Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders. Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development.

Table of Contents

Front Cover.
Half Title Page.
Translational Epigenetics Series.
Title Page.
Copyright Page.
List of Contributors.
Neuropsychiatric Disorders and Epigenetics: General Aspects.
1: Introduction to Neuropsychiatric Disorders and Epigenetics.
2: Environmental Factors and Epigenetics of Neuropsychiatric Disorders.
3: Epigenetic Biomarkers in Neuropsychiatric Disorders.
Epigenetics of Neuropsychiatric Disorders.
4: Epigenetics and Cognitive Disorders—Translational Aspects.
5: Epigenetics in Pervasive Developmental Disorders: Translational Aspects.
6: Epigenetic Causes of Intellectual Disability—The Fragile X Syndrome Paradigm.
7: Epigenetics of Attention-Deficit Hyperactivity Disorder.
8: The Epigenetics of Brain Aging and Psychiatric Disorders.
9: Epigenetics and Down Syndrome.
10: Epigenetics and Multiple Sclerosis.
11: Epigenetics and Migraine.
12: The Role of Epigenetics in the Pathophysiology of Epilepsy.
13: Epigenetic Dysregulation in Brain Tumors and Neurodevelopment.
14: Epigenetics and Cerebrovascular Diseases.
15: Epigenetics and Eating Disorders.
16: Epigenetics and Obesity.
17: Epigenetics and Drug Addiction: Translational Aspects.
18: Epigenetics and Alcohol Use Disorders.
Summary and Outlook.
19: Neuropsychiatric Disorders and Epigenetics: Summary and Outlook.