Synthetic Biology, 1st Edition

  • Published By:
  • ISBN-10: 0123978203
  • ISBN-13: 9780123978202
  • DDC: 660.6
  • Grade Level Range: College Freshman - College Senior
  • 352 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013

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Synthetic Biology provides a framework to examine key enabling components in synthetic biology. Chapters contributed by experts address tools and methodologies developed to engineer biological systems at the molecular, pathway, network, whole cell, and multi-cell level. The book highlights practical applications of synthetic biology such as microbial production of biofuels and drugs, artificial cells, synthetic viruses, and artificial photosynthesis. The roles of computers and computational design are discussed, as well as future prospects in the field. Synthetic biology is the design and construction of new biological entities, such as enzymes and genetic circuits, or the redesign of existing systems. It builds on advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry. What distinguishes synthetic biology from traditional molecular and cellular biology is its focus on designing and building core components that can be modeled and tuned to meet specific performance criteria and the assembly of these components into larger systems that solve specific problems.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
1: Synthesis and Engineering Tools in Synthetic Biology.
2: New Tools for Cost-Effective DNA Synthesis.
3: Protein Engineering as an Enabling Tool for Synthetic Biology.
4: Pathway Engineering as an Enabling Synthetic Biology Tool.
5: From Biological Parts to Circuit Design.
6: Computational and Theoretical Tools in Synthetic Biology.
7: Theoretical Considerations for Reprogramming Multicellular Systems.
8: Computational Protein Design for Synthetic Biology.
9: Computer-Aided Design of Synthetic Biological Constructs with the Synthetic Biology Software Suite.
10: Computational Methods for Strain Design.
11: Applications in Synthetic Biology.
12: Design and Application of Synthetic Biology Devices for Therapy.
13: Drug Discovery and Development Via Synthetic Biology.
14: Synthetic Biology of Microbial Biofuel Production: From Enzymes to Pathways to Organisms.
15: Tools for Genome Synthesis.
16: Synthetic Microbial Consortia and their Applications.
17: Future Prospects.
18: Semi-Synthetic Minimal Cells Biochemical, Physical, and Technological Aspects.
19: Transforming Synthetic Biology with Cell-Free Systems.
20: Towards Engineered Light–Energy Conversion in Nonphotosynthetic Microorganisms.
21: Applications of Engineered Synthetic Ecosystems.