Cancer Metastasis: Biologic Basis And Therapeutics, 1st Edition

  • Published By:
  • ISBN-10: 1139136208
  • ISBN-13: 9781139136204
  • DDC: 616.99
  • Grade Level Range: College Freshman - College Senior
  • 642 Pages | eBook
  • Original Copyright 2011 | Published/Released December 2011
  • This publication's content originally published in print form: 2011

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Comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease.

Table of Contents

Front Cover.
Cancer Metastasis.
Title Page.
Copyright Page.
Overview: Biology Is the Foundation of Therapy.
1: Basic Research.
2: Introduction to Basic Research.
3: Models and Tools for Metastasis Studies.
4: Animal Models of Cancer Metastasis.
5: Drosophila and Zebrafish: Genetic Models for Cancer Metastasis.
6: Computational Models.
7: Intravital Microscopy to Visualize Invasion and Metastasis.
8: Genes.
9: Metastasis-Promoting Genes.
10: The Role of Metastasis Suppressor Genes in Metastasis.
11: Stromal-Derived Factors That Dictate Organ-Specific Metastasis.
12: Metastasis Genes: Epigenetics.
13: Germline Variation and Other Host Determinants of Metastatic Potential.
14: The Influence of Aging and Cellular Senescence on Metastasis.
15: Various Properties of Cancer Cells.
16: The Continuum of Epithelial Mesenchymal Transition – Implication of Hybrid States for Migration and Survival in Development and Cancer.
17: Apoptosis, Anoikis, and Senescence.
18: Metastatic Inefficiency and Tumor Dormancy.
19: Stromal Cells/Extracellular Matrix.
20: Role of Inflammation in Metastatic Progression.
21: Proteolytic Cascades in Invasion and Metastasis.
22: Role of Matrix Metalloproteinases in Tumor Invasion and Metastasis.
23: Cell-Derived Microvesicles and Metastasis.
24: Systemic Factors.
25: Exploring the Earliest Steps in Metastasis: The Pre-Metastatic Niche.
26: Growth Regulatory Pathways Contributing to Organ Selectivity of Metastasis.
27: Determinants of Organ-Specific Metastasis.
28: Function and Expression of the uPA/uPAR System in Cancer Metastasis.
29: The Lymphatics: On the Route to Cancer Metastasis.
30: Clinical Reseaech.
31: Introduction to Clinical Research.
32: Sarcoma.
33: Neuroblastoma.
34: Retinoblastoma.
35: Primary Brain Tumors and Cerebral Metastases.
36: Head and Neck Cancer Metastasis.
37: Cutaneous Melanoma: Therapeutic Approaches for Metastatic Disease.
38: Gastric Cancer Metastasis.
39: Metastatic Pancreatic Cancer.
40: Metastasis of Primary Liver Cancer.
41: Advances in Management of Metastatic Colorectal Cancer.
42: Lung Cancer Metastasis.
43: Metastatic Thyroid Cancer: Evaluation and Treatment.
44: Metastatic Renal Cell Carcinoma.
45: Bladder Cancer.
46: Bone Complications of Myeloma and Lymphoma.
47: Breast Metastasis.
48: Gynecologic Malignancies.
49: Prostate Cancer Metastasis: Thoughts on Biology and Therapeutics.
50: The Biology and Treatment of Metastatic Testicular Cancer.
51: Applications of Proteomics to Metastasis Diagnosis and Individualized Therapy.
52: Critical Issues of Research on Circulating and Disseminated Tumor Cells in Cancer Patients.
53: Lymphatic Mapping and Sentinel Lymph Node Biopsy.
54: Molecular Imaging and Metastasis.
55: Preserving Bone Health in Malignancy and Complications of Bone Metastases.
56: Role of Platelets and Thrombin in Metastasis.
57: Therapies.
58: Cancer Nanotechnology Offers Great Promise for Cancer Research and Therapy.
59: Metronomic Chemotherapy for Treatment of Metastatic Disease: From Preclinical Research to Clinical Trials.
60: Immunotherapy.
61: Discovery and Development of Drugs Targeting Tumor Invasion and Metastasis.
62: The Role of Radiotherapy in the Treatment of Metastatic Disease.
63: Prospects for Clinical Trials of Metastasis Inhibitors.