Ascaris: The Neglected Parasite, 1st Edition

  • Published By:
  • ISBN-10: 012397285X
  • ISBN-13: 9780123972859
  • DDC: 614.5
  • Grade Level Range: College Freshman - College Senior
  • 460 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013

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This book tackles a number of different perspectives concerning the parasitic helminth Ascaris, both in animals and in humans and the disease known as ascariasis. It seeks to identify interesting, exciting and novel aspects, which will interest readers from a broad range of disciplines. Over a quarter of the world's population are infected with the human roundworm, and the equivalent in pigs is equally ubiquitous. Both contribute to insidious and chronic nutritional morbidity, and this has been quantified, in humans, as disability adjusted life years approximating 10.5 million. Ascaris larvae develop in host parenteral tissues, and the resultant pathology has been condemnation. Ascariasis, despite its staggering global prevalence and the sheer numbers of people it infects, remains a classic neglected disease. However, renewed interest in the consequences of early infection with worms from the perspective of immune modulation, co-infections and the development of allergy further enhances the relevance of these parasites.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
1: Biology of Ascaris.
2: Immunology of Ascaris and Immunomodulation.
3: Ascaris and Allergy.
4: Ascaris – Antigens, Allergens, Immunogenetics, Protein Structures.
5: Implications of Ascaris Co-infection.
6: Model Systems.
7: Larval Ascariasis: Impact, Significance, and Model Organisms.
8: The Neurobiology of Ascaris and Other Parasitic Nematodes.
9: Epidemiology of Ascariasis.
10: Ascaris Lumbricoides: New Epidemiological Insights and Mathematical Approaches.
11: Genetic Epidemiology of Ascaris: Cross-Transmission between Humans and Pigs, Focal Transmission, and Effective Population Size.
12: Transmission Dynamics of Ascaris Lumbricoides – Theory and Observation.
13: Host and Parasite Genetics.
14: From the Twig Tips to the Deeper Branches: New Insights into Evolutionary History and Phylogeography of Ascaris.
15: Decoding the Ascaris Suum Genome Using Massively Parallel Sequencing and Advanced Bioinformatic Methods – Unprecedented Prospects for Fundamental and Applied Research.
16: Genetics of Human Host Susceptibility to Ascariasis.
17: Clinical Aspects and Public Health.
18: Ascaris Lumbricoides and Ascariasis: Estimating Numbers Infected and Burden of Disease.
19: Impact of Ascaris Suum in Livestock.
20: Approaches to Control of STHs Including Ascariasis.
21: Diagnosis and Control of Ascariasis in Pigs.