Multiple Sclerosis and Related Disorders, 1st Edition

  • Published By:
  • ISBN-10: 044463309X
  • ISBN-13: 9780444633095
  • DDC: 616.834
  • Grade Level Range: College Freshman - College Senior
  • 736 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013

  • Price:  Sign in for price



Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system.  While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets.  MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis. Over the past five years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology and genetic factors related to MS, the introduction of new technologies and tests to better diagnose and predict the future course of the disease and the introduction of new treatments targeting MS.  This collection of review chapters provides a comprehensive reference into the science and clinical applications of the latest Multiple Sclerosis research and will be a valuable resource for the neuroscience research community and the clinical neurology community of researchers and practitioners.

Table of Contents

Front Cover.
Half Title Page.
Other Frontmatter.
Title Page.
Copyright Page.
Handbook of Clinical Neurology 3rd Series.
1: Pathogenesis.
2: Immune Rregulation of Multiple Sclerosis.
3: Pathology of Multiple Sclerosis and Related Inflammatory Demyelinating diseases.
4: The Good and the Bad of Neuroinflammation in Multiple Sclerosis.
5: Demyelination in Multiple Sclerosis.
6: Axonal Loss in Multiple Sclerosis: Causes and Mechanisms.
7: Insights from Magnetic Resonance Imaging.
8: Infections and Multiple Sclerosis.
9: The Experimental Autoimmune Encephalomyelitis (EAE) Model of MS: Utility for Understanding Disease Pathophysiology and Treatment.
10: Epidemiology and Genetics.
11: Multiple Sclerosis Genetics.
12: Genetics of Primary Progressive Multiple Sclerosis.
13: The Epidemiology of Multiple Sclerosis: Insights to Disease Pathogenesis.
14: Diagnosis and Disease Course.
15: Multiple Sclerosis: Diagnosis, Differential Diagnosis, and Clinical Presentation.
16: MRI Mimics of Multiple Sclerosis.
17: Diagnosis of Multiple Sclerosis.
18: The Clinical Course of Multiple Sclerosis.
19: Early Prognosis of Multiple Sclerosis.
20: Clinical Outcome Measures in Multiple Sclerosis.
21: MRI Outcomes in the Diagnosis and Disease Course of Multiple Sclerosis.
22: Multiple Sclerosis in Children.
23: Treatment.
24: Clinical Trials in Multiple Sclerosis.
25: Glucocorticoid Treatment of Multiple Sclerosis.
26: Disease-Modifying Agents in Multiple Sclerosis.
27: Immunosuppressive Treatments in Multiple Sclerosis.
28: Symptomatic Treatment and Management of Multiple Sclerosis.
29: Future Treatment Approaches to Multiple Sclerosis.
30: Other Demyelinating Diseases.
31: Neuromyelitis Optica (Devic’s Syndrome).
32: Acute Disseminated Encephalomyelitis and Other Inflammatory Demyelinating Variants.
33: Acute Inflammatory Myelopathies.
34: Capita Selecta.
35: Clinical Neurophysiology of Multiple Sclerosis.
36: Cerebrospinal Fluid Analysis.