eBook Structural and Functional Characterization of the Immunoproteasome, 1st Edition

  • Published By:
  • ISBN-10: 3319015567
  • ISBN-13: 9783319015569
  • DDC: 571.9648
  • Grade Level Range: College Freshman - College Senior
  • 82 Pages | eBook
  • Original Copyright 2013 | Published/Released April 2014
  • This publication's content originally published in print form: 2013
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In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.

Table of Contents

Front Cover.
Half Title Page.
Other Frontmatter.
Title Page.
Copyright Page.
Other Frontmatter.
Supervisor's Foreword.
1: Objective.
2: Materials and Methods.
3: Results.
4: Discussion.