eBook Principles of Molecular Diagnostics and Personalized Cancer Medicine, 1st Edition

  • Dongfeng Tan
  • Published By: Lippincott Williams & Wilkins
  • ISBN-10: 1469820641
  • ISBN-13: 9781469820644
  • DDC: 616.99
  • Grade Level Range: College Freshman - College Senior
  • 992 Pages | eBook
  • Original Copyright 2013 | Published/Released January 2015
  • This publication's content originally published in print form: 2013
  • Price:  Sign in for price

About

Overview

The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today's subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Dedication Page.
Contributors.
Preface.
Contents.
Introduction of Cancer Biology and Cancer Genetics.
1: Cell Proliferation and Apoptosis.
2: Cancer Stem Cells.
3: Cell Signal Transduction.
4: Oncogenes.
5: Tumor Suppressor Genes.
6: Viruses and Human Cancers: Pathogenesis and Therapeutic Implication.
7: Molecular Techniques.
8: Introduction to Molecular Techniques and Instrumentation.
9: Transcriptome Analysis.
10: Immunohistochemistry.
11: Cancer Genomic Sequencing.
12: Mass Spectrometry: Principles and Applications in Cancer Diagnosis and Management.
13: Cancer Proteomics.
14: Morphoproteomics.
15: Flow Cytometry.
16: Cancer Cytogenomics.
17: DNA Hypermethylation in Cancer.
18: Single Nucleotide Polymorphisms.
19: Molecular Tests and Cancer Management.
20: Overview of Molecular Tests and Personalized Cancer Medicine.
21: Molecular Screening, Genetic Counseling, and Cancer Prevention: Lynch Syndrome as a Model.
22: Molecular Imaging and Cancer Management: PET and MR Agents for Molecular Imaging of Cancer Metabolism.
23: Detection and Molecular Monitoring of Minimal Residual Diseases in Myeloid Neoplasms.
24: Molecular Assessment of Cancer Prognosis.
25: Quality Control, Assurance, and Standardization of Molecular Diagnostics.
26: Biostatistics and Bioinformatics.
27: In Vitro Companion Diagnostic and Anti-Cancer Drug Co-Development: Regulatory Perspectives.
28: Molecular Diagnostics of Common Malignancies.
29: Molecular Biology and Pathology of Lung Cancer: Genotype–Morphology Correlation.
30: Molecular Diagnostics of Breast Cancer.
31: Molecular Diagnostics of Colorectal Cancer.
32: Molecular Diagnostics of Esophageal and Gastric Cancers.
33: Molecular Biology of Prostate Cancer: Practical Considerations for Diagnosis and Prognosis.
34: Molecular Diagnostics of Hepatocellular Carcinoma.
35: Molecular Diagnostics of Pancreatic Cancer.
36: Molecular Diagnostics of Head and Neck Cancer.
37: Immunohistochemical and Molecular Diagnosis of Melanoma.
38: Molecular Diagnostics of Hematopoietic Neoplasms.
39: Molecular Diagnostics of Lymphomas.
40: Molecular Diagnostics of Gynecologic Neoplasms.
41: Molecular Diagnostics of Bladder and Kidney Cancers.
42: Molecular Diagnosis of Soft Tissue Sarcomas.
43: Molecular Diagnosis of Glioma.
44: Molecular Diagnostics of Pediatric Neoplasms.
45: Molecular Diagnostics of Metastatic Malignancies.
46: Molecular Basis of Cancer Therapeutics.
47: DNA Repair and Cancer Therapeutics.
48: Monoclonal Antibodies for the Treatment of Cancer.
49: Vaccines and Cancer Therapy.
50: Cancer Gene Therapy: Nucleic Acids as Therapeutic Agents.
51: Anti-Angiogenesis Therapy of Cancer.
52: Micrornas and Cancer Therapeutics.
53: Molecular Basis of Cancer Radiation Treatment.
54: Nanotechnology and Cancer Therapy.
55: New Approaches to Integration of Personalized Medicine in Early Cancer Drug Development.
56: Personalized Medicine and Targeted Therapy of Cancer.
57: Personalized Medicine and Targeted Therapy of Lung Cancer.
58: Personalized Medicine and Targeted Therapy of Breast Cancer.
59: Personalized Medicine and Targeted Therapy for Colorectal Cancer.
60: Personalized Medicine and Targeted Therapy of Esophageal Cancer.
61: Personalized Medicine and Targeted Therapy of Gastric Cancer.
62: Personalized Medicine and Targeted Therapy for Prostate Cancer.
63: Personalized Medicine and Targeted Therapy of Hepatocellular Carcinoma.
64: Personalized Medicine and Targeted Therapy of Pancreatic Cancer: Current Status and Proposed Strategies.
65: Personalized Medicine and Targeted Therapy of Neuroendocrine Neoplasms.
66: Personalized Medicine and Targeted Therapy of Head and Neck Cancer.
67: Personalized Medicine and Targeted Therapy for Melanoma.
68: Personalized Medicine and Targeted Therapy of Leukemia.
69: Personalized Medicine and Targeted Therapy of Gynecologic Cancers.
70: Personalized Medicine and Targeted Therapy of Renal Cell Carcinoma.
71: Personalized Medicine and Targeted Therapy of Gliomas.
72: Personalized Medicine and Targeted Therapy for Osteosarcoma.
73: Molecular Basis of Chemoradiotherapy and High-Precision Radiotherapy.
74: Future of Molecular Diagnostics and Personalized Cancer Medicine.
75: New Approaches to Personalized Medicine and Targeted Drug Discovery.
76: The Future of Molecular Diagnostics in Oncology.
Index.