eBook Regenerative Medicine Applications in Organ Transplantation, 1st Edition

  • Published By:
  • ISBN-10: 012398520X
  • ISBN-13: 9780123985200
  • DDC: 617.954
  • Grade Level Range: College Freshman - College Senior
  • 1050 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013
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About

Overview

Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Dedication.
Contents.
Meet the Editors.
List of Contributors.
Preface: Solid Organ Transplantation in the Regenerative Medicine Era.
1: Introduction: Regenerative Medicine and Solid Organ Transplantation from a Historical Perspective.
2: Solid Organ Transplantation: Has the Promise Been Kept and the Needs Met?.
3: Principles of Regenerative Medicine and Cell, Tissue, and Organ Bioengineering.
4: Strategies for the Specification of Tissue Engineering Biomaterials.
5: Principles of Stem Cell Biology.
6: Principles of Cell Sheet Technology.
7: Principles of Bioprinting Technology.
8: Synthetic Biomaterials for Regenerative Medicine Applications.
9: Natural Biomaterials for Regenerative Medicine Applications.
10: Bioartificial Biomaterials for Regenerative Medicine Applications.
11: Bioactivated Materials for Cell and Tissue Guidance.
12: Biocompatibility and Immune Response to Biomaterials.
13: Harnessing Regenerative and Immunomodulatory Properties of Mesenchymal Stem Cells in Transplantation Medicine.
14: Bioreactors for Tissue Engineering Purposes.
15: Kidney.
16: Current Status of Renal Transplantation.
17: Living Donor Renal Transplantation Progress, Pitfalls, and Promise.
18: Machine Perfusion of Kidneys Donated after Circulatory Death: The Carrel and Lindbergh Legacy.
19: Renal Regeneration: The Bioengineering Approach.
20: Renal Regeneration: The Stem Cell Biology Approach.
21: Renal Regeneration: The Developmental Approach.
22: Liver.
23: Current Status of Liver Transplantation.
24: Living-Related Liver Transplantation: Progress, Pitfalls, and Promise.
25: Donation after Cardiac Death in Liver Transplantation.
26: Artificial Liver Support.
27: Liver Regeneration: The Bioengineering Approach.
28: Liver Regeneration: The Developmental Biology Approach.
29: Liver Regeneration: The Stem Cell Approach.
30: Liver Regeneration and Bioengineering: The Role of Liver Extra-Cellular Matrix and Human Stem/Progenitor Cells.
31: Heart.
32: Current Status of Heart Transplantation.
33: Artificial Heart Support.
34: Heart Regeneration: The Bioengineering Approach.
35: Heart Regeneration: The Developmental and Stem Cell Biology Approach.
36: Small Bowel.
37: Current Status of Intestinal Transplantation.
38: Living Related Small Bowel Transplantation: Progress, Pitfalls, and Promise.
39: Intestinal Regeneration: The Bioengineering Approach.
40: Intestinal Regeneration: The Developmental Biology Approach.
41: Intestinal Regeneration: The Stem Cell Approach.
42: Building Blocks for Engineering the Small Intestine.
43: Endocrine Pancreas and Islets of Langerhans.
44: Current Status of Pancreas Transplantation.
45: Living-Donor Pancreas Transplantation: Progress, Pitfalls, and Promise.
46: Current Status of Islet Transplantation.
47: Pancreatic Islets Regeneration: The Bioengineering Approach.
48: Pancreatic Islet Regeneration: The Developmental and Stem Cell Biology Approach.
49: Microencapsulation Technology.
50: Autologous Islets Transplantation.
51: Lung.
52: Current Status of Lung Transplantation.
53: Living Related Lung Transplantation: Progress, Pitfalls, and Promise.
54: Artificial Lung Support.
55: Lung Regeneration: The Bioengineering Approach.
56: Lung Regeneration: The Developmental Biology Approach.
57: Lung Regeneration: The Stem Cell Approach.
58: Composite Tissues Allotransplantation.
59: Current Status of CTA.
60: Bioengineering of the Lower Urinary Tract.
61: Upper Airways Regeneration and Bioengineering.
62: Skin Regeneration and Bioengineering.
63: The Use of Skin Substitutes in the Treatment of Burns.
64: Bone Regeneration and Bioengineering.
65: Nerve Regeneration and Bioengineering.
66: Vessel Regeneration and Bioengineering.
67: Corneal Bioengineering.
68: Esophagus Bioengineering.
69: Immunosuppression-Free Transplantation in the Regenerative Medicine Era.
70: Stem Cell-Based Approach to Immunomodulation.
71: Immunosuppression-Free Renal Transplantation.
72: Immunosuppression-Free Liver Transplantation.
73: Biomarkers of Operational Tolerance in Liver Transplantation.
74: Biomarkers of Tolerance in Renal Transplantation.
75: Immunocloaking.
76: The Need for Immune Modulation Despite Regenerative Medicine.
77: Stem Cells Approach to I/R Injury.
78: Xenotransplantation: Past, Present, and Future.
79: Regenerative Medicine as an Industry.
80: Ethics in Regenerative Medicine and Transplantation.
81: Epilogue: Organ Bioengineering and Regeneration as the New Holy Grail of Organ Transplantation.
Index.