eBook The Synapse, 1st Edition

  • Published By:
  • ISBN-10: 0124186823
  • ISBN-13: 9780124186828
  • DDC: 612.8
  • Grade Level Range: College Freshman - College Senior
  • 512 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013
  • Price:  Sign in for price



The Synapse summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases. Part 1 provides an in-depth look at structural differences and distribution of various pre- and post-synaptic proteins found at glutamatergic synapses. Part 2 is dedicated to dendritic spines and their associated perisynaptic glia, which together constitute the tripartite synapse. The spines are portrayed as major sites for calcium sequestration and local protein synthesis. Part 3 highlights the important regional and cellular differences between glutamatergic transmission and that of neurotransmitters such as dopamine and acetylcholine that are commonly found in axon terminals without synaptic membrane specializations. Part 4 provides an overview of the synapse from the time of formation to degeneration under the powerful influence of aging or hormonal decline that leads to severe deficits in cognitive function. Each chapter is illustrated with drawings and images derived from calcium imaging, electron microscopic immunolabeling, or electrophysiology. This book is a valuable reference for neuroscientists and clinical neurologists in both research and clinical settings.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
List of Contributors.
1: Structure and Complexity of the Synapse and Dendritic Spine.
2: The Molecular Mechanisms Underlying Synaptic Transmission: A View of the Presynaptic Terminal.
3: The First Hour in the Life of a Synapse: Contact Formation, Partner Selection, and Onset of Function.
4: Structural and Functional Organization of the Postsynaptic Density.
5: The Tripartite Synapse: A Role for Glial Cells in Modulating Synaptic Transmission.
6: Local Protein Synthesis at Synapses.
7: Estrogen Effects on Hippocampal Synapses.
8: Trafficking of Glutamate Receptors and Associated Proteins in Synaptic Plasticity.
9: Structural Alterations of Synapses in Psychiatric and Neurodegenerative Disorders.
10: Synaptic Correlates of Aging and Cognitive Decline.
11: Activity-Induced Fine Structural Changes of Synapses in Mammalian Central Nervous System.
12: Activity-Mediated Structural Plasticity of Dendritic Spines.
13: Experience-Dependent Synaptic Plasticity in the Developing Cerebral Cortex.
14: Asynaptic and Synaptic Innervation by Acetylcholine Neurons of the Central Nervous System.
15: Prefrontal Cortical Dopamine Transmission: Ultrastructural Studies and Their Functional Implications.