eBook Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors, 1st Edition

  • Published By:
  • ISBN-10: 012394791X
  • ISBN-13: 9780123947918
  • DDC: 572.696
  • Grade Level Range: College Freshman - College Senior
  • 488 Pages | eBook
  • Original Copyright 2014 | Published/Released June 2014
  • This publication's content originally published in print form: 2014
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About

Overview

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Contents.
Contributors.
Preface.
1: Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors.
2: Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Potential for CNS Disorders.
3: Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery.
4: G Protein-Coupled Receptors in Cancer: Biochemical Interactions and Drug Design.
5: GPCRs in Stem Cell Function.
6: Application of Receptor Theory to Allosteric Modulation of Receptors.
7: What Ligand-Gated Ion Channels Can Tell Us About the Allosteric Regulation of G Protein-Coupled Receptors.
8: Modeling Cooperativity Effects in Dimeric G Protein-Coupled Receptors.
9: Chemokine Receptor Oligomerization and Allostery.
10: Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators.
Index.
Other Backmatter.