eBook Therapeutic Strategies in Cancer Biology and Pathology, 1st Edition

  • Published By:
  • ISBN-10: 0124165907
  • ISBN-13: 9780124165908
  • DDC: 616.994
  • Grade Level Range: College Freshman - College Senior
  • 310 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013
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About

Overview

Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. The emphasis in this book is on how appropriate these genes are as molecular targets and how practicable are the constituents of their signal transduction systems as potential candidates and how accessible they are to targeted therapy. Written in a straightforward and clear style with background information supporting the new research, this book will be useful for students and researchers in cancer therapies.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Dedication.
Contents.
Preface.
Abbreviations.
Introduction.
1: RNA Interference in Genetic Regulation.
2: The Biogenesis and Functions of MicroRNAs.
3: Association of miRNAs with Pathogenesis.
4: Are miRNAs Suitable Targets for Cancer Therapy?.
5: EMT Associated Gene Targeting.
6: Hedgehog Signalling in EMT.
7: Targeted Inhibition of Hh, Wnt, TGF-β Signalling Complex.
8: Encountering Aberrant Wnt Signalling.
9: Therapeutic Targeting of TGF-β Signalling.
10: EGFR Signalling in EMT.
11: Therapeutic Deployment of Metastasis-Associated Gene Function.
12: S100A4 as a Potential Target.
13: MTAs in Cancer Invasion and Metastasis.
14: Genetic Determinants of Tumour and Metastasis Suppression.
15: Metastasis Suppressor nm23 and Manipulation of its Expression.
16: The Metastasis Suppressor KiSS-1 Gene.
17: KAI1 (CD82) Suppresses Metastasis, Cell Proliferation and Invasion.
18: 14-3-3 Proteins in Normal and Tumour Cell Biology.
19: Suppressor Function of NDRG1.
20: The ING (Inhibitor of Growth) Suppressor Gene.
21: The BRCA1 and BRCA2 Suppressor Genes.
22: BRMS1 (Breast Cancer Metastasis Suppressor 1) Gene.
23: Maspin (SerpinB5): a Postulated Tumour Suppressor.
24: EPB41L3 and CADM1 Tumour Suppressor Function.
25: Signalling and Transcription Regulators as Prospective Candidates in Cancer Therapy.
26: Is MKK a Metastasis Suppressor?.
27: RKIP Suppresses Invasion and Metastasis.
28: CRSP3 Metastasis Suppressor.
29: The Suppressor Function of TXNIP.
30: The Essence of the Hippo Signalling System.
31: HIC1 Suppressor Gene.
32: The DLC Suppressor Genes.
33: The LKB1 (STK11) Suppressor Gene.
34: PLCD1 Suppresses Tumorigenesis.
35: Inhibitor of DNA Binding Proteins in Tumours.
36: PDCD4 (Programmed Cell Death 4).
Epilogue.
References.