eBook The Autoimmune Diseases, 5th Edition

  • Published By:
  • ISBN-10: 0123849306
  • ISBN-13: 9780123849304
  • DDC: 616.978
  • Grade Level Range: College Freshman - College Senior
  • 1304 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013
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Since publication of the 4th Edition of The Autoimmune Diseases in 2006, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels and includes expanded coverage of autoinflammatory disease and autoimmune responses to tumors. Gives a thorough and an important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and therapy.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
List of Contributors.
1: Immunologic Basis of Autoimmunity.
2: Autoimmune Disease: The Consequence of Disturbed Homeostasis.
3: Autoimmunity: A History of the Early Struggle for Recognition.
4: General Features of Autoimmune Disease.
5: The Concept of Autoinflammatory Diseases.
6: Immune Cells and Immune Responses.
7: Innate and Adaptive Systems of Immunity.
8: T Cells and their Subsets in Autoimmunity.
9: Immunological Tolerance—T Cells.
10: The Role of Invariant Natural Killer T Cells in Autoimmune Diseases.
11: B Cell Development: How to Become One of the Chosen Ones.
12: B Cell Activation and B Cell Tolerance.
13: Non-Antigen-Specific Recognition.
14: Role of Macrophages in Autoimmunity.
15: Dendritic Cells in Autoimmune Disease.
16: Natural Killer Cells.
17: Granulocytes: Neutrophils, Basophils, Eosinophils.
18: The Roles and Contributions of the Complement System in the Pathophysiology of Autoimmune Diseases.
19: Cytokines, their Receptors and Signals.
20: Initiation of Autoimmunity.
21: Cellular Injury and Apoptosis.
22: Autophagy in Autoimmunity.
23: Infectious Triggers of T Cell Autoimmunity.
24: Autoimmune Diseases: The Role for Vaccines.
25: Non-infectious Environmental Agents and Autoimmunity.
26: Adhesion Molecules and Chemoattractants in Autoimmunity.
27: Facilitation of Autoimmunity.
28: Effector Mechanisms in Autoimmunity.
29: Sexual Dimorphism in the Immune System.
30: Microbiome and Autoimmunity.
31: Genetic Predisposition, Humans.
32: Genetic Predisposition to Autoimmune Diseases Conferred by the Major Histocompatibility Complex: Utility of Animal Models.
33: Epigenetics and Autoimmune Diseases.
34: Autoimmunity in Primary Immunodeficiency Disorders.
35: Experimental Models of Autoimmunity.
36: Animal Models: Systemic Autoimmune Diseases.
37: Animal Models of Organ-Specific Autoimmune Disease.
38: Multisystem Autoimmune Diseases.
39: Systemic Lupus Erythematosus.
40: Systemic Sclerosis, Scleroderma.
41: Antiphospholipid Syndrome.
42: Sjögren’s Syndrome.
43: Rheumatoid Arthritis.
44: Juvenile Idiopathic Arthritis.
45: Spondyloarthritides.
46: The Autoimmune Myopathies.
47: Endocrine System.
48: Thyroid Disease.
49: Autoimmune (Type 1) Diabetes.
50: Adrenalitis.
51: Polyendocrine Syndromes.
52: Autoimmune Gastritis and Pernicious Anemia.
53: Autoimmune Hypophysitis.
54: Blood Disorders.
55: Autoimmune Hemolytic Anemia.
56: Immune Thrombocytopenia.
57: Autoimmune Neutropenia.
58: Acquired Aplastic Anemia.
59: Monogenic Autoimmune Lymphoproliferative Syndromes.
60: Autoimmune Clotting Dysfunction.
61: Central and Peripheral Nervous System.
62: Multiple Sclerosis.
63: Peripheral Neuropathies.
64: Myasthenia Gravis and Related Disorders.
65: Ocular Disease.
66: Immune-Mediated Inner Ear Disease.
67: Encephalomyelopathies.
68: Paraneoplastic Neurologic Syndromes.
69: Gastrointestinal System.
70: Celiac Disease.
71: Inflammatory Bowel Diseases.
72: Hepatitis.
73: Primary Biliary Cirrhosis.
74: Primary Sclerosing Cholangitis.
75: Autoimmune Pancreatitis and IgG4-related Disease.
76: Skin Diseases.
77: Autoimmune Bullous Skin Diseases—Pemphigus and Pemphigoid.
78: Non-Bullous Skin Diseases: Alopecia Areata, Vitiligo, Psoriasis, and Urticaria.
79: Nephropathies and Reproductive System.
80: Autoimmune Disease in the Kidney.
81: Autoimmune Orchitis and Autoimmune Oophoritis.
82: Cardiovascular System and Lungs.
83: Rheumatic Fever and Rheumatic Heart Disease.
84: Myocarditis and Dilated Cardiomyopathy.
85: Atherosclerosis.
86: Necrotizing Arteritis and Small Vessel Vasculitis.
87: Large and Medium Vessel Vasculitides.
88: Idiopathic and Autoimmune Interstitial Lung Disease.
89: Unclassified Expressions of Autoimmunity.
90: Cameos: Candidates and Curiosities.
91: Autoantibodies Against Cytokines.
92: Diagnosis, Prevention, and Therapy.
93: Autoantibody Assays: Performance, Interpretation, and Standardization.
94: Prediction of Autoimmune Disease.
95: Prevention of Autoimmune Disease: The Type 1 Diabetes Paradigm.
96: Treatment of Autoimmune Disease: Established Therapies.
97: Treatment of Autoimmune Disease: Biological and Molecular Therapies.