eBook Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, 1st Edition

  • Volume 2
  • Published By:
  • ISBN-10: 0124115144
  • ISBN-13: 9780124115149
  • DDC: 571.655
  • Grade Level Range: College Freshman - College Senior
  • 440 Pages | eBook
  • Original Copyright 2013 | Published/Released June 2014
  • This publication's content originally published in print form: 2013
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an authoritative examination of the role of autophagy in health and disease. Understanding this phenomenon is vital in the study of cancer, aging, neurodegeneration, immunology, and infectious diseases. This four-volume work is a valuable guide to cellular processes and encourages researchers to explore their potentially important connections. Understanding the role of autophagy is critical, considering its association with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, amyotrophic lateral sclerosis, and prion diseases. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. Despite the increasing importance of autophagy in various pathophysiological conditions, this process is underestimated and overlooked. As a result, its role in the initiation, stability, maintenance, and progression of these and other diseases is poorly understood. This work broadens the knowledge of academic and clinical professors, post-doctoral fellows, and graduate and medical students.

Table of Contents

Front Cover.
Half Title Page.
Title Page.
Copyright Page.
Other Front Matter.
Abbreviations and Glossary.
Autophagy: Volume 1 –Contributions.
List of Contributions Projected in Volumes 3–4.
1: Introduction to Autophagy Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volumes 1–4.
2: Proteins.
3: Selective Autophagy: Role of Interaction between the Atg8 Family Interacting Motif and Atg8 Family Proteins.
4: Mammalian Autophagy Can Occur Through an Atg5/Atg7-Independent Pathway.
5: Selective Autophagy: Role of Ubiquitin and Ubiquitin-Like Proteins in Targeting Protein Aggregates, Organelles, and Pathogens.
6: Ubiquitin and p62 in Selective Autophagy in Mammalian Cells.
7: Role of the Golgi Complex and Autophagosome Biogenesis in Unconventional Protein Secretion.
8: Pathogens.
9: Induction of Autophagy in HIV-1-Uninfected Cells: Role of Fusogenic Activity of gp41.
10: Non-Lipidated LC3 is Essential for Mouse Hepatitis Virus Infection.
11: Suppression of Innate Antiviral Immunity after Hepatitis C Virus Infection: Role of the Unfolded Protein Response and Autophagy.
12: Mycobacterial Survival in Alveolar Macrophages as a Result of Coronin-1a Inhibition of Autophagosome Formation.
13: Virulent Mycobacteria Upregulate Interleukin-6 (IL6) Production to Combat Innate Immunity.
14: Autophagy in Parasitic Protists.
15: Cell Surface Pathogen Receptor CD46 Induces Autophagy.
16: Helicobacter pylori Infection and Autophagy: A Paradigm for Host–Microbe Interactions.
17: Immunity.
18: Autophagy is Required during Monocyte–Macrophage Differentiation.
19: Role of the Autophagy Gene Atg5 in T Lymphocyte Survival and Proliferation.
20: General Diseases.
21: Sepsis-Induced Autophagy is a Protective Mechanism against Cell Death.
22: Blockage of Lysosomal Degradation is Detrimental to Cancer Cell Survival:Role of Autophagy Activation.
23: Autophagy as a Sensitization Target in Cancer Therapy.
24: Pathogenesis of Bile Duct Lesions in Primary Biliary Cirrhosis.
25: Autophagy and NADPH Oxidase Activity Tend to Regulate Angiogenesis in Pulmonary Artery Endothelial Cells with Pulmonary Hypertension.
26: Role of Autophagy in Heart Disease.
27: Regulation of Autophagy in Obesity-Induced Cardiac Dysfunction.
28: Cytochrome P4502E1, Oxidative Stress, JNK, and Autophagy in Acute Alcohol-Induced Fatty Liver.
29: Autophagy-Independent Tumor Suppression:Role of UV Radiation Resistance Associated Gene.
30: Chaperone-Mediated Autophagy and Degradation of Mutant Huntingtin Protein.
31: The Role of Atg8 Homologue in Lewy Body Disease.